Results 31 to 40 of about 426,940 (310)
, 2023 Objectives: In the context of COVID-19, patients with a severe or critical illness may be more susceptible to developing secondary bacterial infections.
Maj. María Simón Sacristán +6 more
core +1 more source
Emerging nanobiomaterials against bacterial infections in postantibiotic era
View, 2020 Although numerous antibiotics have been developed and applied in clinic, bacterial infections are still serious threats to human health, due to the rapidly growing antibiotic resistance all over the world.
Dengfeng Hu +4 more
doaj +1 more source
Menadione as Antibiotic Adjuvant Against P. aeruginosa: Mechanism of Action, Efficacy and Safety [PDF]
Antibiotic resistance in chronic lung infections caused by Pseudomonas aeruginosa requires alternative approaches to improve antibiotic efficacy. One promising approach is the use of adjuvant compounds that complement antibiotic therapy.
Marc Schneider +5 more
core +1 more source
Antimicrobial Stewardship & Healthcare EpidemiologyWe investigated the impact of rapid diagnostic testing with real-time stewardship intervention on patients with Streptococcal bacteremia. Compared to pre-intervention, patients in the post-intervention group received more rapid antibiotic de-escalation ...
Tyler Tate +2 more
doaj +1 more source
The impact of healthcare-associated infection on mortality: failure in clinical recognition is related with inadequate antibiotic therapy. [PDF]
PLoS ONE, 2013 PURPOSE: To understand if clinicians can tell apart patients with healthcare-associated infections (HCAI) from those with community-acquired infections (CAI) and to determine the impact of HCAI in the adequacy of initial antibiotic therapy and hospital ...
Teresa Cardoso +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-HematologicalPatients. Antibiotics (Basel). [PDF]
, 2023 Objectives: to assess the current epidemiology, antibiotic therapy and outcomes of oncohematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for ...
Paula Pons-Oltra +27 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Avoiding pitfalls in antibiotic therapy: the antibiotic stewardship approach
Magna Scientia UCEVA, 2022 The aim of this reflection is to determine the effectiveness and safety of ABS interventions. A strong correlation between antibiotic overuse and the growing worldwide resistance, but also with individual side effects is well established and should open
Markus H. Huppertz-Thyssen +1 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source