Results 51 to 60 of about 426,940 (310)

Immunohistochemical monitoring of wound healing in antibiotic treated buruli ulcer patients [PDF]

, 2014
While traditionally surgery has dominated the clinical management of Buruli ulcer (BU), the introduction of the combination chemotherapy with oral rifampicin and intramuscular streptomycin greatly improved treatment and reduced recurrence rates.
Arianna Andreoli, Gerd Pluschke, Andreoli, Arianna, Sopoh, Ghislain Emmanuel, Marie-Thérèse Ruf, Ghislain Emmanuel Sopoh, Peter Schmid, Ruf, Marie-Thérèse, Pluschke, Gerd, Schmid, Peter   +9 more
core   +1 more source

Outcome of Irrigation and Debridement with Topical Antibiotic Delivery Using Antibiotic-Impregnated Calcium Hydroxyapatite for the Management of Periprosthetic Hip Joint Infection

, 2023
We assessed the clinical results of irrigation and debridement (I&D) with antibiotic-impregnated calcium hydroxyapatite (CHA) as a novel antibiotic delivery system for the treatment of prosthetic-joint-associated infection (PJI) after total hip ...
Hiroki Wakabayashi, Akihiro Sudo, Masahiro Hasegawa, Yohei Naito, Shine Tone   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study

Antimicrobial Resistance and Infection Control, 2020
Background In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in hospitals through analysis of the antibiotic ...
Jannicke Slettli Wathne, Brita Skodvin, Esmita Charani, Stig Harthug, Hege Salvesen Blix, Roy M. Nilsen, Lars Kåre Selland Kleppe, Marta Vukovic, Ingrid Smith   +8 more
doaj   +1 more source

A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections.

, 2010
In a clinical infection, multiplying and non-multiplying bacteria co-exist. Antibiotics kill multiplying bacteria, but they are very inefficient at killing non-multipliers which leads to slow or partial death of the total target population of microbes in
Liu, Y, Alireza Shamaei-Tousi, Coates Anthony, Shamaei-Tousi, A, Hu, Y, Liu Yingjun, Yanmin Hu, Hu Yanmin, Yingjun Liu, Shamaei-Tousi Alireza, Anthony Coates, Coates, A   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: a prospective observational study

BMC Infectious Diseases, 2007
Background Several strategies to optimise the use of antibiotics have been developed. Most of these interventions can be classified as educational or restrictive.
Battegay Manuel, Bingisser Roland, Widmer Andreas F, Sendi Pedram, Simcock Mathew, Mettler Julian, Fluckiger Ursula, Bassetti Stefano   +7 more
doaj   +1 more source

Frontline antibiotic therapy [PDF]

Clinical Medicine, 2013
The need to use front-line antibiotics wisely has never been greater. Antibiotic resistance and multi-drug resistant infection, driven by antibiotic use, remain major public health and professional concerns. To overcome these infection problems, use of older antibiotics active against multi drug-resistant pathogens is increasing - for example, colistin,
MacGowan, Alasdair P, Albur, Mahableshwar S   +1 more
openaire   +3 more sources

Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance

, 2023
Acinetobacter baumannii is a nosocomial pathogen of serious healthcare concern that is becoming increasingly difficult to treat due to antibiotic treatment failure.
Daniel Flaherty, William L. Johnson, Xufeng Cao, Catlyn Blanchard, Paul M. Dunman, Mikaeel Young, Michaelle Chojnacki   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source