Results 41 to 50 of about 426,940 (310)
BMC MicrobiologyPhage therapy has been explored and used compassionately in the post-antibiotic era, though phage resistance might pose a serious challenge. The advent of hypervirulent and hypermucoviscous traits in Klebsiella pneumoniae limits therapeutic choices. This
Ramya Juliet, Ramesh Nachimuthu
doaj +1 more source
Pharmacoeconomics of Antibiotic Therapy
Canadian Journal of Infectious Diseases, 1994 During the past few years new drugs with greatly improved efficacy have become available to physicians and their patients. The higher purchase price of these new drugs is quite important and is quoted as a significant cause of the escalating cost of ...
Jacques Le Lorier
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
International Journal of Infectious Diseases, 2019 Background: Optimizing antibiotic therapy has an important impact on the management of critically ill patients. Procalcitonin (PCT) is considered to be of possible use in the guidance of antibiotic stewardship; however, its efficacy remains controversial.
Fei Peng +5 more
doaj +1 more source
Antibiotic prescribing on two medical wards at St Luke’s Hospital : what scope for improvement? [PDF]
, 1996 Antibiotics are frequently prescribed drugs and form a significant part of the hospital budget. The literature suggests that prescribing is not without problems and may need constant review. We have no data relating to our hospital.
Fenech, Frederick F. +3 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Local audit of empiric antibiotic therapy in bacteremia: A retrospective cohort study.
PLoS ONE, 2021 BackgroundIt is unclear if a local audit would be useful in providing guidance on how to improve local practice of empiric antibiotic therapy. We performed an audit of antibiotic therapy in bacteremia to evaluate the proportion and risk factors for ...
Anthony D Bai +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Community-Acquired Pneumonia in Children: Current Approaches to the Duration of Antibiotic Therapy
Zdorovʹe Rebenka, 2016 Antibiotic therapy is recognized as the only scientifically valid method for the treatment of pneumonia, the outcome of which depends on proper antibiotic and the optimal duration of its administration that ensures the achievement of microbial ...
S.O. Mokiia-Serbina +2 more
doaj +1 more source
The guidelines on antibiotic application in gynaecological oncology [PDF]
Archive of Oncology, 2005 Standardized and effective antibiotic therapy regimes in gynecology need to be based on the protocols prescribed by acknowledged specialists. Antibiotic therapy can have either prophylactic or therapeutic purposes.
Mladenović-Segedi Ljiljana +4 more
doaj +1 more source