Results 41 to 50 of about 3,260,507 (313)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
BMC MicrobiologyPhage therapy has been explored and used compassionately in the post-antibiotic era, though phage resistance might pose a serious challenge. The advent of hypervirulent and hypermucoviscous traits in Klebsiella pneumoniae limits therapeutic choices. This
Ramya Juliet, Ramesh Nachimuthu
doaj +1 more source
Pharmacoeconomics of Antibiotic Therapy
Canadian Journal of Infectious Diseases, 1994 During the past few years new drugs with greatly improved efficacy have become available to physicians and their patients. The higher purchase price of these new drugs is quite important and is quoted as a significant cause of the escalating cost of ...
Jacques Le Lorier
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Principles of respiratory tract infection rational antibiotic therapy
, 2021 Continuously increasing resistance of infectious agents together with rapid decrease in the number of novel antibacterial drugs makes the rational antibiotic selection one of the important challenges facing modern medicine.
Oksana V. Fesenko, null null
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Community-Acquired Pneumonia in Children: Current Approaches to the Duration of Antibiotic Therapy
Zdorovʹe Rebenka, 2016 Antibiotic therapy is recognized as the only scientifically valid method for the treatment of pneumonia, the outcome of which depends on proper antibiotic and the optimal duration of its administration that ensures the achievement of microbial ...
S.O. Mokiia-Serbina +2 more
doaj +1 more source
Summary of antibiotic therapy.
, 2018 Summary of antibiotic therapy.
Philip Kam-To Li (5204129) +6 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Local audit of empiric antibiotic therapy in bacteremia: A retrospective cohort study.
PLoS ONE, 2021 BackgroundIt is unclear if a local audit would be useful in providing guidance on how to improve local practice of empiric antibiotic therapy. We performed an audit of antibiotic therapy in bacteremia to evaluate the proportion and risk factors for ...
Anthony D Bai +4 more
doaj +1 more source