Results 81 to 90 of about 3,260,507 (313)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study

, 2014
BACKGROUND: In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking.AIMS:
Verheij, Theo J M, Leven, Margareta, Moore, Michael, Thomas, Mike, Verheij, Theo J.M., Coenen, Samuel, Stuart, Beth, Goossens, Herman, Little, Paul, van Erp, Nicole, Hood, Kerenza, Butler, Chris C., JC onderzoeksprogramma Infectious Diseases, JC onderzoeksprogramma Cancer, Ieven, Margareta, HAG Oncologie, Infection & Immunity, HAG Infectieziekten, et al.   +18 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Impact of antibiotic therapy on the development and response to treatment of immune checkpoint inhibitor-mediated diarrhea and colitis

Journal for ImmunoTherapy of Cancer, 2019
Background The gut microbiome impacts the efficacy of immune checkpoint inhibitor (ICI) therapy and the development of ICI-mediated diarrhea and/or colitis (IMDC).
Hamzah Abu-Sbeih, Lauren Nicholas Herrera, Tenglong Tang, Mehmet Altan, Anne-Maria P. Chaftari, Pablo C. Okhuysen, Robert R. Jenq, Yinghong Wang   +7 more
doaj   +1 more source

Factors Associated with Prolonged Antibiotic Therapy in Neonates with Suspected Early-Onset Sepsis [PDF]

Early-onset sepsis (EOS) is a rare but profoundly serious bacterial infection. Neonates at risk of EOS are often treated with antibiotics. The start of empiric antibiotic therapy can successfully be reduced by the implementation of the EOS calculator ...
Bo M. van der Weijden, Niek B. Achten, Plötz, Frans B., Frans B. Plötz, van Dorth, Jolien R., van der Weijden, Bo M., Achten, Niek B.; id_orcid, Jolien R. van Dorth   +7 more
core   +1 more source

Immunohistochemical monitoring of wound healing in antibiotic treated buruli ulcer patients [PDF]

, 2014
While traditionally surgery has dominated the clinical management of Buruli ulcer (BU), the introduction of the combination chemotherapy with oral rifampicin and intramuscular streptomycin greatly improved treatment and reduced recurrence rates.
Arianna Andreoli, Gerd Pluschke, Andreoli, Arianna, Sopoh, Ghislain Emmanuel, Marie-Thérèse Ruf, Ghislain Emmanuel Sopoh, Peter Schmid, Ruf, Marie-Thérèse, Pluschke, Gerd, Schmid, Peter, Schmid Peter, Pluschke G, Ruf Marie-Thérèse, Pluschke Gerd, Andreoli Arianna, Ruf MT, Sopoh Ghislain Emmanuel, Sopoh GE, Andreoli A, Schmid P   +19 more
core   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Antibiotic Use Before CAR-T Treatment Is Associated with Inferior Outcomes in DLBCL Lymphoma Patients

Biomedicines
Background/Objectives: CAR-T-cell therapy has become a key treatment for relapsed or refractory hematologic malignancies such as diffuse large B-cell lymphoma (r/r DLBCL), although patient outcomes differ considerably.
Anja Bullegas, Inna Shaforostova, Katja Seipel, Marie-Noëlle Kronig, Henning Nilius, Ulrike Bacher, Thomas Pabst   +6 more
doaj   +1 more source

Antimicrobial Lock Therapy: A Strategy for Managing Catheter-Related Bacteremia

Objectives: This study aims to evaluate the use and efficacy of antibiotic-lock therapy (ALT) in the management of catheter-related bloodstream infections (CRBSIs), focusing on its impact on infection resolution, catheter retention, and clinical outcomes.
Firdevs Aksoy, Hanife Nur Karakoc Parlayan, Gulter Oncu Kurutas, Gurdal Yilmaz, KARAKOÇ PARLAYAN, HANİFE NUR, AKSOY, FİRDEVS, ÖNCÜ KURUTAŞ, GÜLTER, YILMAZ, GÜRDAL   +7 more
core   +1 more source