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Proton motive force and antibiotic tolerance in bacteria [PDF]

Microbial Biotechnology
Bacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐population, commonly known as persisters, does not respond to antibiotics and remains viable upon prolonged antimicrobial treatment.
Yingkun Wan, Jiaqi Zheng, Edward Wai‐Chi Chan, Sheng Chen   +3 more
doaj   +5 more sources

Pleiotropic cellular responses underlying antibiotic tolerance in Campylobacter jejuni [PDF]

Frontiers in Microbiology
Antibiotic tolerance enables antibiotic-susceptible bacteria to withstand prolonged exposure to high concentrations of antibiotics. Although antibiotic tolerance presents a major challenge for public health, its underlying molecular mechanisms remain ...
Eunshin Cho, Eunshin Cho, Jinshil Kim, Jinshil Kim, Jinshil Kim, Jinshil Kim, Jeong In Hur, Jeong In Hur, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu, Byeonghwa Jeon   +11 more
doaj   +2 more sources

Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection [PDF]

mBio
Pseudomonas aeruginosa routinely causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). In MADs, P. aeruginosa forms antibiotic-tolerant biofilm-like aggregates within hyperconcentrated airway mucus.
Matthew G. Higgs, Matthew A. Greenwald, Cristian Roca, Jade K. Macdonald, Ashelyn E. Sidders, Brian P. Conlon, Matthew C. Wolfgang   +6 more
doaj   +2 more sources

A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges [PDF]

Antibiotics
Background: Antibiotic tolerance in Staphylococcus aureus biofilms poses a major clinical challenge in prosthetic joint infections (PJIs). This study aimed to characterize the antibiotic tolerance of clinical S.
María Ángeles Meléndez-Carmona, Irene Muñoz-Gallego, Mikel Mancheño-Losa, Jaime Lora-Tamayo   +3 more
doaj   +2 more sources

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae. [PDF]

PLoS Pathogens
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem
Trevor Cross, Facundo Torres, Nadia Nikulin, Abigail P McGee, Leena Jalees, Rhea Balakrishnan, Tolani Aliyu, Lars F Westblade, Abhyudai Singh, Tobias Dörr   +9 more
doaj   +2 more sources

Restriction of arginine induces antibiotic tolerance in Staphylococcus aureus [PDF]

Nature Communications
Staphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment.
Jeffrey A. Freiberg, Valeria M. Reyes Ruiz, Brittney D. Gimza, Caitlin C. Murdoch, Erin R. Green, Jacob M. Curry, James E. Cassat, Eric P. Skaar   +7 more
doaj   +2 more sources

Antibiotic tolerance due to restriction of cAMP-Crp regulation by mannitol, a non-glucose-family PTS carbon source [PDF]

mSphere
Enzyme-IIA (EIIAGlc, Crr) of the phosphotransferase system (PTS) connects the uptake of glucose-family sugars to the cAMP-Crp regulatory cascade; phosphorylated EIIAGlc enhances cAMP-Crp activity, which then contributes to the antibiotic-mediated ...
Weiwei Zhu, Miaomiao Chen, Xue Zhang, Jie Su, Xinyang Zhang, Yuejuan Nong, Bowen Wang, Weihong Guo, Yunxin Xue, Dai Wang, Yiqun Liao, Jianjun Niu, Yuzhi Hong, Karl Drlica, Xilin Zhao   +14 more
doaj   +2 more sources

Antibiotic tolerance and persistence in clinical isolates of Escherichia coli evaluated by high-resolution time-kill assays [PDF]

Microbiology Spectrum
Bacteria showing tolerance to antibiotic killing are characterized by a slower kill rate compared with other isolates from the same species. Antibiotic persistence is defined by a subpopulation of bacteria showing a reduced kill rate when an isolate is ...
N. R. Alexandersen, K. L. Nielsen, S. Häussler, T. Bjarnsholt, K. Schønning   +4 more
doaj   +2 more sources

Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni

Microbiology Spectrum, 2022
Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance.
Myungseo Park, Jinshil Kim, Jill Feinstein, Kevin S. Lang, Sangryeol Ryu, Byeonghwa Jeon   +5 more
doaj   +1 more source

Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]

, 2020
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael, Fauvart, Maarten, Franke, Sabine, Hofkens, Johan, Marchal, Kathleen, Michielsen, Jan, Weytjens, Bram, Wilmaerts, Dorien, Zahir, Taiyeb   +8 more
core   +2 more sources