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The Impact of Triclosan on the Spread of Antibiotic Resistance in the Environment [PDF]

open access: yes, 2015
Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1 × 105 to 4.2 × 105 kg of TCS are discharged from these WWTPs per year in the United States.
Carey, Daniel E., McNamara, Patrick J.
core   +6 more sources

Evolution of Bacterial Tolerance Under Antibiotic Treatment and Its Implications on the Development of Resistance

open access: yesFrontiers in Microbiology, 2021
Recent laboratory evolution studies have shown that upon repetitive antibiotic treatments, bacterial populations will adapt and eventually became tolerant and resistant to the drug.
Jordy Evan Sulaiman, Henry Lam
doaj   +1 more source

Targeting Antibiotic Tolerance, Pathogen by Pathogen [PDF]

open access: yesCell, 2018
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the ...
Meylan, Sylvain   +2 more
openaire   +4 more sources

Antimicrobial Efficacy against Antibiotic-Tolerant Staphylococcus aureus Depends on the Mechanism of Antibiotic Tolerance

open access: yesAntibiotics, 2022
Bacteria can adapt to a changing environment by adopting alternate metabolic states favoring small molecule synthesis and resilience over growth. In Staphylococcus aureus, these states are induced by factors present during infection, including nutritional limitations, host responses and competition with other bacteria.
Emily M. Meredith   +2 more
openaire   +3 more sources

The role of individual exopolysaccharides in antibiotic tolerance of Pseudomonas aeruginosa aggregates

open access: yesFrontiers in Microbiology, 2023
The bacterium Pseudomonas aeruginosa is involved in chronic infections of cystic fibrosis lungs and chronic wounds. In these infections the bacteria are present as aggregates suspended in host secretions.
Ziwei Liang   +8 more
doaj   +1 more source

Genetic Determinants for Metal Tolerance and Antimicrobial Resistance Detected in Bacteria Isolated from Soils of Olive Tree Farms

open access: yesAntibiotics, 2020
Copper-derived compounds are often used in olive tree farms. In a previous study, a collection of bacterial strains isolated from olive tree farms were identified and tested for phenotypic antimicrobial resistance and heavy metal tolerance.
Nicolás Glibota   +3 more
doaj   +1 more source

Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms. [PDF]

open access: yesPLoS Pathogens, 2011
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant ...
Sasan Amini   +3 more
doaj   +1 more source

Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs [PDF]

open access: yes, 2019
Strategies to reduce economic losses associated with post-weaning diarrhea in pig farming include high-level dietary zinc oxide supplementation.
Bethe, Astrid   +10 more
core   +2 more sources

Concentration-dependent activity of antibiotics in natural environments

open access: yesFrontiers in Microbiology, 2013
Bacterial responses to antibiotics are concentration dependent. At high concentrations, antibiotics exhibit antimicrobial activities on susceptible cells, while subinhibitory concentrations induce diverse biological responses in bacteria. At non-lethal
Steve P Bernier, Michael G Surette
doaj   +1 more source

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

open access: yesmBio, 2022
Metabolic and growth arrest are primary drivers of antibiotic tolerance and persistence in clinically diverse bacterial pathogens. We recently showed that adenosine (ADO) suppresses bacterial growth under nutrient-limiting conditions.
David A. Kitzenberg   +7 more
doaj   +1 more source

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