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Antibiotic tolerance: targeting bacterial survival
Current Opinion in Microbiology, 2023 Antimicrobial susceptibility testing is the cornerstone of antibiotic treatments. Yet, active drugs are frequently unsuccessful in vivo and most clinical trials investigating antibiotics fail. So far, bacterial survival strategies, other than drug resistance, have been largely ignored.
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Antimicrobial Peptides Can Generate Tolerance by Lag and Interfere with Antimicrobial Therapy
Pharmaceutics, 2022 Antimicrobial peptides (AMPs) are widely distributed molecules secreted mostly by cells of the innate immune system to prevent bacterial proliferation at the site of infection.
Daniel Sandín +4 more
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Tolerance and safety of the potentially probiotic strain Lactobacillus rhamnosus PRSF-L477 : a randomised, double-blind placebo-controlled trial in healthy volunteers [PDF]
, 2010 In Europe, the species Lactobacillus rhamnosus is currently on the Qualified Presumption of Safety list used by the European Food Safety Authority (EFSA) for internal safety assessment, but according to the EFSA the species should remain a topic of ...
Huys, Geert +4 more
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Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population [PDF]
, 2020 Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming.
Debski, Pawel R. +9 more
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Antimicrobial Resistance and Infection Control, 2023 Background Due to the substantial increase in the use of disinfectants containing quaternary ammonion compounds (QACs) in healthcare and community settings during the COVID-19 pandemic, there is increased concern that heavy use might cause bacteria to ...
John M. Boyce
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Microbiology Spectrum, 2021 Antibiotic tolerance is not only the key underlying the cause of recurrent and chronic bacterial infections but it is also a factor linked to exacerbation of diseases, such as tuberculosis, cystic fibrosis-associated lung infection, and candidiasis. This
Yingkun Wan +3 more
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Microbiology Spectrum, 2023 Carbohydrate metabolism plays essential roles in energy generation and providing carbon skeletons for amino acid syntheses. In addition, carbohydrate metabolism has been shown to influence bacterial susceptibility to antibiotics and virulence.
Hao Chen +8 more
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Piacentinu Ennese PDO cheese as reservoir of promising probiotic bacteria [PDF]
, 2019 Piacentinu Ennese is a protected designation of origin (PDO) cheese produced in the surrounding area of Enna (Sicily, Italy), using raw ewe’s milk without the addition of any starter cultures.
Caggia, Cinzia +6 more
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Proteolytic Queues at ClpXP Increase Antibiotic Tolerance [PDF]
ACS Synthetic Biology, 2019 AbstractAntibiotic tolerance is a widespread phenomenon that renders antibiotic treatments less effective and facilitates antibiotic resistance. Here we explore the role of proteases in antibiotic tolerance, short-term population survival of antibiotics, using queueing theory (i.e.
Heather S. Deter +5 more
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Antibiotic tolerance and persistence have distinct fitness trade-offs.
PLoS Pathogens, 2022 Genetically susceptible bacteria can escape the action of bactericidal antibiotics through antibiotic tolerance or persistence. However, one major difference between the two phenomena is their distinct penetrance within an isogenic population. While with
Charlotte Michaux +3 more
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