Results 81 to 90 of about 185,660 (297)
Molecular analysis of antibiotic tolerance in pneumococci
International Journal of Medical Microbiology, 2002 Widespread pneumococcal resistance and the emergence of tolerance underscores the need to develop new antimicrobials. Uncovering the mechanisms of autolysin activation could yield not only new antibacterial targets but also ways to eradicate a pool of bacteria facilitating the spread of resistance.
Lauren S, Mitchell, Elaine I, Tuomanen
openaire +2 more sources
Advanced Functional Materials, EarlyView.A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao +6 more
wiley +1 more source
npj Antimicrobials and ResistanceAntibiotic tolerance, the ability to survive lethal antibiotics for a prolonged period of time is a rising threat due to its role as a steppingstone towards antibiotic resistance. While tolerance has been recognized as a severe clinical threat, little is
Megan Renee Keller +6 more
doaj +1 more source
Biocompatible but Antibacterial Mechanism of Graphene Oxide for Sustainable Antibiotics
Advanced Functional Materials, EarlyView.Graphene oxide (GO) exhibits selective antibacterial activity through specific interactions between its oxygen functional groups and bacterial membrane phospholipid POPG, causing membrane destabilization while maintaining biocompatibility. Model membrane studies and infected wound models in mice and pigs demonstrate effective bacterial suppression and ...
Sujin Cha +15 more
wiley +1 more source
Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments [PDF]
, 2018 Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers.
Chan, Ting-Fung +8 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
Erythromycin treatment hinders the induction of oral tolerance to fed ovalbumin
Frontiers in Immunology, 2012 The mucosal immune system is constantly exposed to antigen, whether it be food antigen, commensal bacteria, or harmful antigen. It is essential that the mucosal immune system can distinguish between harmful and non-harmful antigens, and initiate an ...
Sydney E. Lambert +4 more
doaj +1 more source
Relationship between antibiotic- and disinfectant-resistance profiles in bacteria harvested from tap water [PDF]
, 2016 Chlorination is commonly used to control levels of bacteria in drinking water; however, viable bacteria may remain due to chlorine resistance. What may be concerning is that surviving bacteria, due to co-selection factors, may also have increased ...
Beattie, Tara K. +2 more
core +1 more source
Epistasis between antibiotic tolerance, persistence, and resistance mutations [PDF]
Proceedings of the National Academy of Sciences, 2019 SignificanceThe failure of antibiotic treatment is a major concern worldwide. Resistance is a main determinant in the survival of bacteria under antibiotics. However, it is often observed that bacteria become recalcitrant to antibiotics treatment, without developing resistance, a phenomenon termed “tolerance.” Here we explored the interactions between ...
Levin-Reisman, Irit +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash +4 more
wiley +1 more source