Incentivizing Narrow-Spectrum Antibiotic Development with Refunding [PDF]
Bull Math Biol 84, 59 (2022), 2020 The rapid rise of antibiotic resistance is a serious threat to global public health. Without further incentives, pharmaceutical companies have little interest in developing antibiotics, since the success probability is low and development costs are huge.
arxiv +1 more source
Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia
Pharmaceuticals, 2021 Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more ...
Mashiro Okunaka +4 more
doaj +1 more source
An overview of diagnosis and management of drug‐induced hypomagnesemia
Pharmacology Research & Perspectives, 2021 Magnesium (Mg) is commonly addressed as the “forgotten ion” in medicine. Nonetheless, hypomagnesemia should be suspected in clinical practice in patients with relevant symptomatology and also be considered a predisposing factor for the development of ...
George Liamis +3 more
doaj +1 more source
European surveillance of infections in cancer patients - ESIC [PDF]
, 1999 Major advances in cancer therapy result from development of multidrug chemotherapy regimens. Besides death from tumor progression, infections are currently one of the major causes of mortality and morbidity.
Buchheidt, D. +7 more
core +1 more source
Adjunctive Impact of Mitochondria-Targeting Antibiotics for Cancer Stem Cells of Oral Squamous Cell Carcinoma: Proposal for a Novel Approach in Resistant Cases [PDF]
Journal of DentistryDear SirOral Squamous Cell Carcinoma (OSCC) is the most common cancer involving the oral and maxillofacial area [1]. OSCC is reported to exert the worst quality of life among the patients suffering from head and neck cancers [2].
Mohammad Amin Amiri +3 more
doaj +1 more source
A Systematic Review of Dental Disease in Patients Undergoing Cancer Therapy [PDF]
, 2010 Introduction: The purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus ...
Brian D. Hodgson +8 more
core +4 more sources
Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]
, 2020 The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali +2 more
core +1 more source
Intracellular acidification is a hallmark of thymineless death in E. coli.
PLoS Genetics, 2022 Thymidine starvation causes rapid cell death. This enigmatic process known as thymineless death (TLD) is the underlying killing mechanism of diverse antimicrobial and antineoplastic drugs.
Alexandra Ketcham +2 more
doaj +1 more source
Frontiers in Chemistry, 2022 Bacterial resistance to antibiotics is an ever-growing problem in heathcare. We have previously identified a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich type complexes with bidentate monosaccharide ligands possessing ...
Bence Balázs +11 more
doaj +1 more source
Drug-induced anaphylaxis in China: a 10 year retrospective analysis of the Beijing Pharmacovigilance Database [PDF]
, 2017 Background Few studies on the causes of drug-induced anaphylaxis (DIA) in the hospital setting are available. Objective We aimed to use the Beijing Pharmacovigilance Database (BPD) to identify the causes of DIA in Beijing, China.
Li, Xiaotong +7 more
core +1 more source