Results 31 to 40 of about 867,243 (251)
, 1975 Certain bisaziridinopyrrolidinoquinone analogs, which contain the structural moieties essential for physiological activity in the parent antitumor agent mitomycin C, have been synthesized. These compounds efficiently induce covalent cross-links in DNA as
M. H. Akhtar +5 more
semanticscholar +1 more source
Drug cocktail optimization in chemotherapy of cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP).
Saskia Preissner +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
Frontiers in Pharmacology, 2021 The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota.
David Dahlgren +3 more
doaj +1 more source
Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity
FEBS Open Bio, EarlyView.This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2021 BackgroundCancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited.
David Barros Coelho +18 more
doaj +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Brain Sciences, 2023 Background: A wide range of medications may have a possible role in the development of male-factor infertility (MFI), including various antineoplastic agents, testosterone/anabolic steroids, immunosuppressive drugs/immunomodulators, glucocorticosteroids,
Sara Baldini +6 more
doaj +1 more source
Advanced Biology, EarlyView.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Clinical profiles of adverse drug reactions spontaneously reported at a single Korean hospital dedicated to children with complex chronic conditions. [PDF]
PLoS ONE, 2017 Children with complex chronic conditions (CCC) are presumed to be vulnerable to adverse drug reactions (ADRs). The clinical profiles of ADRs in CCC are not well known.
Bomi Kim +7 more
doaj +1 more source