Results 31 to 40 of about 855,762 (278)
Phage-antibiotic synergy inhibited by temperate and chronic virus competition [PDF]
arXiv, 2021 As antibiotic resistance grows more frequent for common bacterial infections, alternative treatment strategies such as phage therapy have become more widely studied in the medical field. While many studies have explored the efficacy of antibiotics, phage therapy, or synergistic combinations of phages and antibiotics, the impact of virus competition on ...
arxiv
, 1975 Certain bisaziridinopyrrolidinoquinone analogs, which contain the structural moieties essential for physiological activity in the parent antitumor agent mitomycin C, have been synthesized. These compounds efficiently induce covalent cross-links in DNA as
M. H. Akhtar +5 more
semanticscholar +1 more source
A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
Pharmaceuticals, 2020 Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting factors in treatments. We developed
Alejandro Cabrera-Andrade +7 more
doaj +1 more source
Drug-induced QT interval prolongation in cancer patients
Oncology Reviews, 2011 Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications.
Torben K. Becker, Sai-Ching J. Yeung
doaj +1 more source
Predicting the dynamics of bacterial growth inhibition by ribosome-targeting antibiotics [PDF]
, 2017 Understanding how antibiotics inhibit bacteria can help to reduce antibiotic use and hence avoid antimicrobial resistance - yet few theoretical models exist for bacterial growth inhibition by a clinically relevant antibiotic treatment regimen. In particular, in the clinic, antibiotic treatment is time dependent.
arxiv +1 more source
Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity [PDF]
arXiv, 2022 Antimicrobial resistance is a silent pandemic that is being exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end as the emergence and spread of antimicrobial ...
arxiv
Drug cocktail optimization in chemotherapy of cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP).
Saskia Preissner +7 more
doaj +1 more source
Ion−π interactions for constructing organic luminescent materials
Aggregate, Volume 3, Issue 6, December 2022., 2022 The construction of organic fluorescence and room temperature phosphorescence materials by using ion−π interactions including anion−π interactions and cation−π interactions is presented in this minireview. The applications of these ion−π type organic luminescent materials in bioimaging, imaging‐guided anticancer, and antibacterial treatment are also ...
Guoyu Jiang +3 more
wiley +1 more source
Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
Frontiers in Pharmacology, 2021 The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota.
David Dahlgren +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 BackgroundCancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited.
David Barros Coelho +18 more
doaj +1 more source