Spatially explicit prioritization of human antibiotics and antineoplastics in Europe
Environment International, 2013 This paper presents a screening tool for the location-specific prioritization of human pharmaceutical emissions in Europe, based on risk quotients for the aquatic environment and human health. The tool provides direction towards either monitoring activities or additional research.
Mark A. J. Huijbregts +6 more
openaire +9 more sources
Hepatotoxicity by Drugs: The Most Common Implicated Agents. [PDF]
, 2016 To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Idiosyncratic drug-induced liver injury (DILI) is
Björnsson, Einar S
core +2 more sources
A review of the effects of pharmaceutical pollutants on humans and aquatic ecosystem [PDF]
Exploration of Drug ScienceThe presence of high-quality water is essential not only for human survival but also for the well-being of plants and animals. This research aimed to examine studies investigating the occurrence of antibiotics, endocrine disruptors, and other ...
Jaya Vinny Eapen +4 more
doaj +1 more source
Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. [PDF]
PLoS Genetics, 2008 Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide.
Kelly N Owens +8 more
doaj +1 more source
Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743. [PDF]
, 2003 We previously showed that COL1A1 expression is up-regulated at the transcriptional level in systemic sclerosis (SSc) fibroblasts and that the CCAAT-binding factor (CBF) is involved in this increased expression.
Herrick, David J +3 more
core +2 more sources
Ranolazine Attenuates Trastuzumab-Induced Heart Dysfunction by Modulating ROS Production [PDF]
, 2018 The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. The late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by ...
Carlo G. Tocchetti +16 more
core +3 more sources
Antibiotic prophylaxis is associated with subsequent resistant infections in children with an initial extended-spectrum-cephalosporin-resistant Enterobacteriaceae infection [PDF]
, 2017 The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin ...
Adler, Amanda L +12 more
core +2 more sources
Phage-antibiotic synergy inhibited by temperate and chronic virus competition [PDF]
arXiv, 2021 As antibiotic resistance grows more frequent for common bacterial infections, alternative treatment strategies such as phage therapy have become more widely studied in the medical field. While many studies have explored the efficacy of antibiotics, phage therapy, or synergistic combinations of phages and antibiotics, the impact of virus competition on ...
arxiv
, 1975 Certain bisaziridinopyrrolidinoquinone analogs, which contain the structural moieties essential for physiological activity in the parent antitumor agent mitomycin C, have been synthesized. These compounds efficiently induce covalent cross-links in DNA as
M. H. Akhtar +5 more
semanticscholar +1 more source
Drug cocktail optimization in chemotherapy of cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP).
Saskia Preissner +7 more
doaj +1 more source