Results 111 to 120 of about 951,869 (260)

Exploring prospects of novel drugs for tuberculosis [PDF]

, 2012
Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However, even for the treatment of drug-sensitive tuberculosis,
Grobusch, M. P., Janssen, S., Jayachandran, R., Khathi, L., Pieters, J., Zinsstag, J.   +5 more
core   +1 more source

Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis [PDF]

, 2019
Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead ...
Fullam, Elizabeth, Gibson, Matthew I., Guy, Collette S., Murray, Kathryn   +3 more
core   +2 more sources

Exploration of the chemistry and biological properties of pyrimidine as a privileged pharmacophore in therapeutics [PDF]

, 2015
The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1.
Ajani, Olayinka O.
core   +1 more source

Pulmonary nocardiosis masquerading renascence of tuberculosis in an immunocompetent host: a case report from Nepal

BMC Research Notes, 2018
Background Pulmonary nocardiosis is an opportunistic infection in an immunocompromised patient; however, often neglected in the immunocompetent patient from the diagnosis considerations.
Priyatam Khadka, Ramesh Bahadur Basnet, Basista Parsad Rijal, Jeevan Bahadur Sherchand   +3 more
doaj   +1 more source

Synthesis and study of new antitubercular compounds

Proceedings of 4th International Electronic Conference on Medicinal Chemistry, 2018
Tuberculosis is regarded as one of the deadliest diseases in the world. It is a bacterial infection caused by some bacteria from the genus Mycobacterium, such as Mycobacterium tuberculosis.
P. Laumaillé, A. Dassonville-Klimpt, P. Sonnet   +2 more
semanticscholar   +1 more source

Pulmonary infection by Mycobacterium riyadhense: first case report in United Arab Emirates

Frontiers in Medicine
Mycobacterium riyadhense is an emerging slowly growing species that belongs to the group of nontuberculous mycobacteria (NTM) with approximately 20 cases reported worldwide.
Batool A. Sawan, Leen O. Saleh, Dina Z. Al Shaltouni, Mohammad A. Sawan, Shefa Gawish, Samar Ahmed, Julio Gomez-Seco, Michael E. Otim   +7 more
doaj   +1 more source

The Effect of Combining Natural Terpenes and Antituberculous Agents against Reference and Clinical Mycobacterium tuberculosis Strains

Molecules, 2018
Background: On account of emergence of multi- and extensively drug-resistant Mycobacterium tuberculosis (Mtb) strains, combinations of drugs with natural compounds were tested to search for antibiotic activity enhancers. In this work we studied terpenes (
Elwira Sieniawska, Rafal Sawicki, Marta Swatko-Ossor, Agnieszka Napiorkowska, Agata Przekora, Grazyna Ginalska, Marta Swatko-Ossor, Ewa Augustynowicz-Kopec   +7 more
doaj   +1 more source

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives [PDF]

, 2010
A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by
Ajani, Olayinka O.
core   +1 more source

Diagnostic delay in ankle and foot tuberculosis resulting in tuberculoma and tuberculous meningitis in a middle-aged female: A case report

SAGE Open Medical Case Reports
A middle-aged woman presents with chronic foot arthritis which progressed to a non-healing ulcer, which was unresponsive to conventional antibiotics and debridement.
Hedwiga F Swai, Sibtain M Moledina, Sylvia B Nsato, Amina Mgunya, Joan Rugemalila, Veridiana Byemelwa, Sharon Ismail, Pauline Chale, Luth Mwapule, Alex Masao, Jude Tarimo, Amunga Meda, Fatuma Muhali, May Shoo, Eva Uiso, Stella Rwezaura, Eliaichi Minja, Deogratius Beda, Sarah K Nyagabona, Onesmo Kisanga, Sayan Salehe, Faraja Chiwanga, Said Mwemba, John Rwegasha, Grace Shayo   +24 more
doaj   +1 more source

Melioidosis: misdiagnosed in Nepal

BMC Infectious Diseases, 2019
Background Melioidosis is a life-threatening infectious disease that is caused by gram negative bacteria Burkholderia pseudomallei. This bacteria occurs as an environmental saprophyte typically in endemic regions of south-east Asia and northern Australia.
Neha Shrestha, Mahesh Adhikari, Vivek Pant, Suman Baral, Anjan Shrestha, Buddha Basnyat, Sangita Sharma, Jeevan Bahadur Sherchand   +7 more
doaj   +1 more source