Results 191 to 200 of about 951,869 (260)

Synthesis and evaluation of novel oxanthrene scaffold-derived oxazolidinone antibiotics with potent antitubercular activity and low cellular toxicity.

Bioorganic & Medicinal Chemistry Letters
Oxazolidinones are a class of antibiotics used to treat bacterial infections in humans and are a component of the treatment regimen for multidrug-resistant tuberculosis. However, current clinically used examples of the class display poor safety profiles,
Kelsey R. Latterell, Evan Keil, Benjamin R. Kraemer, Joe B. Huisken, Ben A. Thomas, Noah Daniels, Amit Kaushik, M. Olson, Pamela Meléndez Noriega, M. A. Daniels, D. Janzen, G. Lamichhane, M. Campo, J. Ippoliti   +13 more
semanticscholar   +1 more source

Discovery of Unprecedented Arylation Coupling Cyclopeptide Inspires Natural Product-like Antitubercular Lead Compounds

JACS Au
Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. Naturally derived antibiotics appear frequently in nature as collections of structurally similar compounds representing an adaptive evolutionary response to drug resistance ...
Qun Zhang, Wei-Feng Xu, Qian-Qian Jing, Yi-Qian Han, Yan-wei Wu, Yu-cheng Gu, Meiyan Wei, Chang-Lun Shao   +7 more
semanticscholar   +1 more source

Pharmacogenetics of First-Line Antitubercular Drugs: An Update.

Therapeutic Drug Monitoring
BACKGROUND Tuberculosis (TB) treatment relies on a prolonged first-line antibiotic regimen, including isoniazid, rifampicin (RF), ethambutol (EMB), and pyrazinamide.Pharmacogenetics plays a crucial role in optimizing TB treatment by addressing individual
A. Manca, A. Calcagno, A. D’Avolio, J. Cusato   +3 more
semanticscholar   +1 more source

Benzyl/phenyl‐1,2,3‐Triazole Tethered 3‐Acetyl Coumarins as Potential Drug‐Resistant Antitubercular Agents: Synthesis, Biology, and in Silico Investigations as Mtb DNA Gyrase Inhibitors

ChemistrySelect
Owing to the emergence of multi‐drug resistant tuberculosis, there is a need for the exploration of new antitubercular agents. In this context, new coumarin‐based 1,2,3‐triazole hybrids were developed and evaluated for their antimicrobial activity ...
Bulti Bakchi, Sarvan Maddipatla, Seshamma Gottemukkala, Shital Raut, Mohammad Naiyaz Ahmad, Mohmmad Imran, Deepanshi Saxena, Rahul Maitra, Puja Kumari Agnivesh, Nitin Pal Kalia, Srinivas Nanduri, A. Dasgupta, Sidharth Chopra, Venkata Madhavi Yaddanapudi   +13 more
semanticscholar   +1 more source

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Future Medicinal Chemistry, 2019
AIM In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis.
Vitthal B. Makane, V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Chopra, D. Sriram, Vijayan N Azger Dusthackeer, H. Rode   +9 more
semanticscholar   +1 more source

Structure-Activity Studies on the Antitubercular Natural Product Evybactin.

ACS Medicinal Chemistry Letters
The escalating threat of antibacterial resistance is a pressing global issue that highlights the urgent need for innovative antibiotics. In this regard, the recent discovery of evybactina nonribosomal depsipeptide antibiotic that selectively and ...
Vladyslav Lysenko, Monique E. Theriault, Fabienne A C Sterk, Parth Choudhari, Sangkeun Son, Kim Lewis, N. Martin   +6 more
semanticscholar   +1 more source

Antimicrobial and Antitubercular Activity of Endophytic Actinobacterium and Streptomyces Sp. SACC 4 Isolated from the Mangrove Plant, Rhizophora apiculate

, 2020
Public health threat due to drug resistant pathogens like Mycobacterium tuberculosis and others necessitates the discovery of novel antibiotics. Actinobacteria from understudied sources is emerging as promising source for novel molecules effective ...
A. S
semanticscholar   +1 more source

Novel Benzoxazoles: Synthesis and Antibacterial, Antifungal, and Antitubercular Activity against Antibiotic-Resistant and -Sensitive Microbes

Zeitschrift für Naturforschung C, 2013
A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and ...
Arisoy, Mustafa, Ozgen, Selda, Kaynak-Onurdag, Fatma, Temiz-Arpaci, Ozlem   +3 more
openaire   +3 more sources

Recent Developments in Azole Compounds as Antitubercular Agent

Mini-Reviews in Organic Chemistry, 2019
Tuberculosis (TB) is a global health disaster and is a wide-reaching hitch. The improper use of antibiotics in chemotherapy of TB patients led to the current problem of tuberculosis therapy which gives rise to Multi-Drug Resistant (MDR) strains. Nitrogen
R. Das, G. S. Asthana, K. A. Suri, D. Mehta, Abhay Asthana   +4 more
semanticscholar   +1 more source

Structural Basis for the Interaction and Processing of β-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis.

ACS Infectious Diseases, 2019
Targeting Mycobacterium tuberculosis peptidoglycans with β-lactam antibiotics represents a strategy to address increasing resistance to antitubercular drugs.
G. A. Libreros-Zúñiga, Catharina Dos Santos Silva, Rafaela Salgado Ferreira, M. Dias   +3 more
semanticscholar   +1 more source