Results 41 to 50 of about 1,881,968 (357)

Assessment of Ceftazidime-Avibactam 30/20-μg Disk, Etest versus Broth Microdilution Results When Tested against Enterobacterales Clinical Isolates

Microbiology Spectrum, 2022
The objective of this research was to evaluate the correlation between inhibitory zones and MIC when testing ceftazidime-avibactam using disk diffusion, Etest, and broth microdilution method established by the Clinical and Laboratory Standards Institute (
Renru Han, Xuelin Yang, Yang Yang, Yan Guo, Dandan Yin, Li Ding, Shi Wu, Demei Zhu, Fupin Hu   +8 more
doaj   +1 more source

Evaluation of the Immunochromatographic NG-Test Carba 5, RESIST-5 O.O.K.N.V., and IMP K-SeT for Rapid Detection of KPC-, NDM-, IMP-, VIM-type, and OXA-48-like Carbapenemase Among Enterobacterales

Frontiers in Microbiology, 2021
BackgroundEnterobacterales are the most common pathogens for nosocomial infections. The emergence and spread of KPC, NDM, and OXA-48-like carbapenemase-producing Enterobacterales with their extensively drug-resistant characteristics have posed great ...
Renru Han, Renru Han, Yan Guo, Yan Guo, Mingjia Peng, Mingjia Peng, Qingyu Shi, Qingyu Shi, Shi Wu, Shi Wu, Yang Yang, Yang Yang, Yonggui Zheng, Yonggui Zheng, Dandan Yin, Dandan Yin, Fupin Hu, Fupin Hu   +17 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Are antibiotics naturally antibiotics?

Journal of Industrial Microbiology & Biotechnology, 2006
Antibiotics have been used for more than 50 years and are the cornerstone of infectious disease treatment; in addition, these low-molecular-weight bioactive compounds have been applied to many other therapeutic purposes. However, there is almost no information on the evolutionary biology or ecology of naturally occurring low-molecular-weight compounds.
openaire   +3 more sources

Oral versus Intravenous Antibiotics for Bone and Joint Infection

New England Journal of Medicine, 2019
BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS
Ho‐Kwong Li, I. Rombach, R. Zambellas, S. Walker, M. McNally, B. Atkins, Benjamin A Lipsky, H. Hughes, D. Bose, Michelle Kümin, C. Scarborough, P. Matthews, A. Brent, J. Lomas, R. Gundle, M. Rogers, Adrian Taylor, B. Angus, I. Byren, A. Berendt, S. Warren, F. Fitzgerald, D. Mack, S. Hopkins, J. Folb, H. Reynolds, E. Moore, J. Marshall, N. Jenkins, C.E. Moran, A. Woodhouse, S. Stafford, A. Seaton, C. Vallance, C. Hemsley, K. Bisnauthsing, J. Sandoe, I. Aggarwal, S. Ellis, Deborah J. Bunn, R. Sutherland, G. Barlow, C. Cooper, C. Geue, N. McMeekin, A. Briggs, P. Sendi, E. Khatamzas, T. Wangrangsimakul, N. Wong, L. Barrett, A. Alvand, Fraser Old, J. Bostock, J. Paul, G. Cooke, G. Thwaites, P. Bejon, M. Scarborough   +58 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

ANTIBIOTICS and RESISTANCE to ANTIBIOTICS

, 2023
Antibiotics are natural or synthetic molecules that can inhibit the growth of bacteria (bacteriostatic) or kill some bacteria (bactericidal) (Gamboa et al, 2022). They exert a specific effect on certain structures or functions of the microorganism.
openaire   +1 more source

Expression of Concern: Rahman et al. An Overview of Antimicrobial Stewardship Optimization: The Use of Antibiotics in Humans and Animals to Prevent Resistance. Antibiotics 2022, 11, 667

Antibiotics
With this notice, the Antibiotics Editorial Office states its awareness of concerns relating to the originality of the concepts and analysis published in this review [...]
Antibiotics Editorial Office
doaj   +1 more source

Optimization of the Nutrient Medium for Flammulina velutipes Submerged Biomass Production and Micromorphology of Its Mycelium

Fermentation, 2021
Based on the assessment of the trophic needs of basidiomycete Flammulina velutipes and the optimization of the composition of the nutrient medium using design of experimental approach, the yield of the submerged biomass of the fungus was increased to 41 ...
Larissa Krasnopolskaya, Maria Shuktueva, Aleksandr Golyshkin, Nailya Almyasheva, Maria Yarina   +4 more
doaj   +1 more source