Results 81 to 90 of about 2,694,182 (391)

Parents' beliefs and knowledge about the management of acute otitis media: A qualitative study [PDF]

, 2015
BACKGROUND: Acute otitis media is a common reason for antibiotic prescribing, despite strong evidence that antibiotics provide minimal benefit. Studies have demonstrated that patients’ (or parents’) expectations of antibiotics often influence general ...
Del Mar, Chris, Hansen, Malene Plejdrup, Hoffmann, Tammy C., Howlett, Janine   +3 more
core   +2 more sources

European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria [PDF]

, 2020
Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate ...
De Waele, Jan, Friggeri, Arnaud, Garnacho-Montero, José, Gustin, Marie Paule, Jean, Astrid, Kohlenberg, Anke, Lepape, Alain, Monnet, Dominique L., Savey, Anne, Vanhems, Philippe   +9 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Worldwide Traceability of Antibiotic Residues from Livestock in Wastewater and Soil: A Systematic Review [PDF]

, 2021
Lizbeth E. Robles Jimenez, Edgar Aranda-Aguirre, Octavio Alonso Castelán Ortega, Beatriz S. Shettino-Bermudez, Rutilio Ortiz-Salinas, Michele Miranda, Xunde Li, Juan Carlos Ángeles-Hernández, Einar Vargas‐Bello‐Pérez, Manuel González-Ronquillo   +9 more
openalex   +1 more source

Oral versus Intravenous Antibiotics for Bone and Joint Infection

New England Journal of Medicine, 2019
BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS
Ho‐Kwong Li, I. Rombach, R. Zambellas, S. Walker, M. McNally, B. Atkins, Benjamin A Lipsky, H. Hughes, D. Bose, Michelle Kümin, C. Scarborough, P. Matthews, A. Brent, J. Lomas, R. Gundle, M. Rogers, Adrian Taylor, B. Angus, I. Byren, A. Berendt, S. Warren, F. Fitzgerald, D. Mack, S. Hopkins, J. Folb, H. Reynolds, E. Moore, J. Marshall, N. Jenkins, C. E. Moran, A. Woodhouse, S. Stafford, A. Seaton, C. Vallance, C. Hemsley, K. Bisnauthsing, J. Sandoe, I. Aggarwal, S. Ellis, Deborah J. Bunn, R. Sutherland, G. Barlow, C. Cooper, C. Geue, N. McMeekin, A. Briggs, P. Sendi, E. Khatamzas, T. Wangrangsimakul, N. Wong, L. Barrett, A. Alvand, Fraser Old, J. Bostock, J. Paul, G. Cooke, G. Thwaites, P. Bejon, M. Scarborough   +58 more
semanticscholar   +1 more source

Unveiling the Impact of Antibiotics and Alternative Methods for Animal Husbandry: A Review

Antibiotics, 2021
Since the 1950s, antibiotics have been used in the field of animal husbandry for growth promotion, therapy and disease prophylaxis. It is estimated that up to 80% of the antibiotics produced by the pharmaceutical industries are used in food production ...
Chuen Xian Low, Loh Teng-Hern Tan, N. Ab Mutalib, Priyia Pusparajah, B. Goh, Kok-Gan Chan, V. Letchumanan, Learn‐Han Lee   +7 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Antimicrobial Activity of Microorganisms Isolated from the Soil of the Tropical Desert of the Sinai Peninsula

Антибиотики и Химиотерапия
Background. The spread of pathogenic antibiotic-resistant microorganisms often leads to the inefficiency of antimicrobial therapy. One of the solutions to this problem is the search for new active natural antibiotics.The aim of the study.
A. L. Kandyba, E. V. Khramtsova, B. F. Vasilyeva, Ju. V. Boykova, A. A. Glukhova, T. A. Efimenko, O. V. Efremenkova   +6 more
doaj   +1 more source

Insights into the Fate and Removal of Antibiotics in Engineered Biological Treatment Systems: A Critical Review.

Environmental Science and Technology, 2019
Antibiotics, the most frequently prescribed drugs of modern medicine, are extensively used for both human and veterinary applications. Antibiotics from different wastewater sources (e.g., municipal, hospitals, animal production, and pharmaceutical ...
A. Oberoi, Yanyan Jia, Huiqun Zhang, S. Khanal, Hui Lu   +4 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source