Results 21 to 30 of about 387,972 (242)

IgY antibodies: The promising potential to overcome antibiotic resistance

Frontiers in Immunology, 2023
Antibiotic resistant bacteria are a growing threat to global health security. Whilst the emergence of antimicrobial resistance (AMR) is a natural phenomenon, it is also driven by antibiotic exposure in health care, agriculture, and the environment ...
Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Aymn T. Abbas, Aymn T. Abbas, Aymn T. Abbas, Christopher Oelkrug, Marwa Tahoon, Sameera Ezzat, Sameera Ezzat, Alimuddin Zumla, Alimuddin Zumla, Alimuddin Zumla, Esam I. Azhar, Esam I. Azhar   +14 more
doaj   +1 more source

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children

Expert Review of Vaccines
Background Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their immune responses across serotypes shared with the 13-valent PCV (PCV13).
Josiah Ryman, Jeffrey R. Sachs, Ka Lai Yee, Natalie Banniettis, Jessica Weaver, Thomas Weiss   +5 more
doaj   +1 more source

The Immunogenicity of Glutaraldehyde Inactivated PTx Is Determined by the Quantity of Neutralizing Epitopes

Vaccines
Background/Objectives: Chemically or genetically detoxified pertussis toxin (PTx) is a crucial antigen component of the acellular pertussis vaccine. Chemical detoxification using glutaraldehyde generally causes significant structural changes to the toxin.
Xi Wang, Xinyue Cui, Chongyang Wu, Ke Tao, Shuyuan Pan, Wenming Wei   +5 more
doaj   +1 more source

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Scientific Reports, 2023
Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek   +7 more
doaj   +1 more source

Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies

Frontiers in Cellular and Infection Microbiology, 2022
The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia, otitis media, septicemia, and meningitis in children and adults. Current prevention and treatment efforts are primarily pneumococcal conjugate vaccines that target the ...
Aaron D. Gingerich, Jarrod J. Mousa, Jarrod J. Mousa, Jarrod J. Mousa   +3 more
doaj   +1 more source

Disease-Enhancing Antibodies Improve the Efficacy of Bacterial Toxin-Neutralizing Antibodies [PDF]

Cell Host & Microbe, 2013
During infection, humoral immunity produces a polyclonal response with various immunoglobulins recognizing different epitopes within the microbe or toxin. Despite this diverse response, the biological activity of an antibody (Ab) is usually assessed by the action of a monoclonal population.
Chow, Siu-Kei, Smith, Cameron, MacCarthy, Thomas, Pohl, Mary Ann, Bergman, Aviv, Casadevall, Arturo   +5 more
openaire   +2 more sources

Single Domain Antibody application in bacterial infection diagnosis and neutralization

Frontiers in Immunology, 2022
Increasing antibiotic resistance to bacterial infections causes a serious threat to human health. Efficient detection and treatment strategies are the keys to preventing and reducing bacterial infections. Due to the high affinity and antigen specificity,
Qian Qin, Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen, Yurong Wen   +11 more
doaj   +1 more source

Human antibody targeting Vibrio cholerae O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera

mBio
Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are crucial determinants of protection against cholera. These antibodies agglutinate bacteria and, even in sub-agglutinating conditions, inhibit V. cholerae motility.
Smriti Verma, Murat Cetinbas, Meagan Kelly, Stefania Senger, Christina S. Faherty, Jeshina Janardhanan, Chanchal R. Wagh, Taufiqur Rahman Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Aklima Akter, Richelle C. Charles, Jason B. Harris, Stephen B. Calderwood, Jens Wrammert, Matthew K. Waldor, Merrill Asp, Jung-Shen Benny Tai, Jing Yan, Peng Xu, Pavol Kováč, Ruslan I. Sadreyev, Firdausi Qadri, Edward T. Ryan   +23 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source