Results 21 to 30 of about 3,053,812 (327)

The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections

Frontiers in Microbiology, 2022
The emergence of antimicrobial resistance (AMR) is rapidly increasing and it is one of the significant twenty-first century’s healthcare challenges. Unfortunately, the development of effective antimicrobial agents is a much slower and complex process ...
M. Cavaco, M. Castanho, V. Neves
semanticscholar   +1 more source

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s Disease

Nature Microbiology, 2021
Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of bacterial pathogens and enhancing host protective immunity via immunological exclusion.
Itai Doron, Marissa Mesko, Xin V. Li, Takato Kusakabe, Irina Leonardi, D. Shaw, William D. Fiers, Woan-Yu Lin, Meghan Bialt-DeCelie, E. Román, R. Longman, J. Pla, P. Wilson, I. Iliev   +13 more
semanticscholar   +1 more source

Functional Activity of Antibodies Directed towards Flagellin Proteins of Non-Typhoidal Salmonella. [PDF]

PLoS ONE, 2016
Non-typhoidal Salmonella (NTS) serovars Typhimurium and Enteritidis are major causes of invasive bacterial infections in children under 5 years old in sub-Saharan Africa, with case fatality rates of ~20%.
Girish Ramachandran, Sharon M Tennant, Mary A Boyd, Jin Y Wang, Mohan E Tulapurkar, Marcela F Pasetti, Myron M Levine, Raphael Simon   +7 more
doaj   +1 more source

Compensatory intestinal immunoglobulin response after vancomycin treatment in humans

Gut Microbes, 2021
Intestinal immunoglobulins (Ig) are abundantly secreted antibodies that bind bacteria and bacterial components in the gut. This binding is considered to accelerate bacterial transit time and prevent the interaction of potentially immunogenic compounds ...
Torsten P. M. Scheithauer, Guido J. Bakker, Maaike Winkelmeijer, Mark Davids, Max Nieuwdorp, Daniël H. van Raalte, Hilde Herrema   +6 more
doaj   +1 more source

Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

npj Vaccines, 2021
Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced
Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan   +10 more
doaj   +1 more source

A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as lupus nephritis. However, the mechanism underlying lupus nephritis development is unclear.
Wenyan Fu, Wenyan Fu, Yu Liu, Yu Liu, Fangjie Liu, Fangjie Liu, Chenghua Liu, Chenghua Liu, Jingjing Li, Jiali Niu, Peng Han, Dan Xu, Jiaojiao Hou, Yuanfang Ma, Jiannan Feng, Jiannan Feng, Zhanguo Li, Rong Mu, Guang Yang, Guang Yang   +19 more
doaj   +1 more source

Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection. [PDF]

PLoS ONE, 2013
Using comparative glycoproteomics, we have previously identified a glycoprotein that is altered in both amount and glycosylation as a function of liver cirrhosis.
Anne Lamontagne, Ronald E Long, Mary Ann Comunale, Julie Hafner, Lucy Rodemich-Betesh, Mengjun Wang, Jorge Marrero, Adrian M Di Bisceglie, Timothy Block, Anand Mehta   +9 more
doaj   +1 more source

Investigation of Cas9 antibodies in the human eye

Nature Communications, 2022
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan   +8 more
doaj   +1 more source

Therapeutic effect of polyclonal lipoprotein SA2275 antibodies on Staphylococcus aureus-induced brain abscess in mice

Di-san junyi daxue xuebao, 2020
Objective To investigate the ability of specific polyclonal antibodies against Staphylococcus aureus (S. aureus) lipoprotein SA2275 to penetrate the blood-brain barrier for inhibiting the formation of S. aureus-induced brain abscess in mice.
ZHENG Ying, ZHENG Ying, YANG Yi, PENG Huagang   +3 more
doaj   +1 more source

Presence of anti-microbial antibodies in liver cirrhosis--a tell-tale sign of compromised immunity? [PDF]

PLoS ONE, 2010
BACKGROUND: Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora ...
Maria Papp, Gary L Norman, Zsuzsanna Vitalis, Istvan Tornai, Istvan Altorjay, Ildiko Foldi, Miklos Udvardy, Zakera Shums, Tamas Dinya, Peter Orosz, Bela Lombay, Gabriella Par, Alajos Par, Gabor Veres, Timea Csak, Janos Osztovits, Ferenc Szalay, Peter Laszlo Lakatos   +17 more
doaj   +1 more source