Results 1 to 10 of about 23,804 (223)

Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair. [PDF]

PLoS Pathogens, 2015
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection.
Julia Esser-von Bieren, Beatrice Volpe, Duncan B Sutherland, Jérôme Bürgi, J Sjef Verbeek, Benjamin J Marsland, Joseph F Urban, Nicola L Harris   +7 more
doaj   +8 more sources

Impact of helminth co-infection and treatment on mycobacterial growth inhibition in UK migrants with TB infection [PDF]

IJTLD Open
BACKGROUND: TB and helminth infections are co-endemic in many parts of the world. This has led to the hypothesis that immunomodulation due to helminth infections could adversely affect the ability to control Mycobacterium tuberculosis infection.
S. Anwar, C.F. Turienzo, L. Tsang, S.G. Smith, H. Fletcher, F. Toulza, J.M. Cliff, M. Brown, H.M. Dockrell   +8 more
doaj   +2 more sources

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm Haemonchus [PDF]

Frontiers in Immunology
Parasitic worm (helminth) infections pose significant threats to global health and livestock productivity. Although mass spectrometry (MS)-based glycomics have revealed that helminths express structurally complex N-glycans, site- and structure-specific ...
Xin Liu, Feng Liu, Hui Liu, Lisha Ye, Yao Zhang, Wenjie Peng, Nishith Gupta, Min Hu, Chunqun Wang   +8 more
doaj   +2 more sources

Humoral immune response to COVID-19 vaccines in onchocerciasis-infected individuals: a field study from Ghana [PDF]

Frontiers in Immunology
IntroductionCOVID-19 vaccines are the most successful medical interventions to reduce disease severity and mortality. Various vaccine platforms with unique properties have been developed. The course of the pandemic was contrary to the initial predictions,
Julia Meyer, Ute Klarmann-Schulz, Ute Klarmann-Schulz, Jennifer Nadal, Jennifer Nadal, Marijo Parcina, Linda Batsa Debrah, Linda Batsa Debrah, Jubin Osei-Mensah, Jubin Osei-Mensah, Derrick Adu Mensah, Derrick Adu Mensah, Derrick Adu Mensah, Monica Ahiadorme, Monica Ahiadorme, Vera Serwaa Opoku, Michael Agyemang Obeng, Eunice Kyaakvile Kuutiero, John Opoku, Alexander Yaw Debrah, Alexander Yaw Debrah, Achim Hoerauf, Achim Hoerauf, Tomabu Adjobimey, Tomabu Adjobimey   +24 more
doaj   +2 more sources

The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]

, 2013
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara, A Roepstorff, A Zhao, A Zhao, Aaron R. Jex, BA Vallance, C Dold, C Moolenbeek, C Zhou, CD Criscione, CV Holland, D Leles, D Masure, Dries Masure, DW Crompton, F van Wijk, G Jungersen, GH Liu, HD Dawson, J Vandesompele, JF Urban Jr, Jimmy Saunders, Johnny Vlaminck, Jozef Vercruysse, KD Mccoy, Koen Chiers, L Eriksen, M Ashraf, M Morimoto, N Arizono, N Foster, N Miquel, NL Harris, P Kermanizadeh, P Nejsum, P O'Lorcain, PA Knight, Peter Geldhof, PI Uston, R Shamri, RM Anthony, RW Li, S Rozen, S Schmidt, Sarah Claerhoudt, Tao Wang, TB Stewart, TJ Anderson, Wim Van den Broeck   +48 more
core   +18 more sources

House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.

PLoS Pathogens, 2021
The establishment of type 2 responses driven by allergic sensitization prior to exposure to helminth parasites has demonstrated how tissue-specific responses can protect against migrating larval stages, but, as a consequence, allow for immune-mediated ...
Pedro Henrique Gazzinelli-Guimaraes, Sasisekhar Bennuru, Rafael de Queiroz Prado, Alessandra Ricciardi, Joshua Sciurba, Jonah Kupritz, Matthew Moser, Olena Kamenyeva, Thomas B Nutman   +8 more
doaj   +1 more source

Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni. [PDF]

PLoS Neglected Tropical Diseases, 2017
Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite
Alba Cortés, Javier Sotillo, Carla Muñoz-Antolí, Javier Molina-Durán, J Guillermo Esteban, Rafael Toledo   +5 more
doaj   +1 more source

Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.

PLoS ONE, 2022
The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced
Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Gülsah Gabriel, Minka Breloer   +4 more
doaj   +1 more source

Schistosome infection intensity is inversely related to auto-reactive antibody levels. [PDF]

PLoS ONE, 2011
In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and auto-reactive antibodies and the ...
Francisca Mutapi, Natsuko Imai, Norman Nausch, Claire D Bourke, Nadine Rujeni, Kate M Mitchell, Nicholas Midzi, Mark E J Woolhouse, Rick M Maizels, Takafira Mduluza   +9 more
doaj   +1 more source

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]

, 2015
Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
A Tarkowski, AL Moncayo, AM Gan, B Min, Cathy Steel, CH Kuo, CM Steppan, D Artis, D Voehringer, DD Taub, DR Herbert, DR Herbert, DR Neill, Edward J. Pearce, F Chen, Gang Chen, GD Thomas, Graham Le Gros, H Helmby, HK Park, HS Jung, J Bethony, J Urban, J Wang, JA Jackson, Jessica C. Jang, JF Urban Jr, JI Odegaard, JJ Reece, Josiah I. Chung, JT Pesce, K Migita, KT Cuenco, L Boring, L Le Goff, L Patel, LC Osborne, M Lehrke, M Lehrke, M Qatanani, Mali Camberis, Mark A. Barnes, Meera G. Nair, MG Nair, MG Nair, MG Nair, Mitchell A. Lazar, MM Pirvulescu, MP Reilly, N Silswal, P Loke, PF Weller, Philip J. Cooper, PJ George, PJ Hotez, R Anuradha, RM Anthony, RT Semnani, RZ Yang, S Babu, S Babu, S Babu, S Babu, S Jiang, S Lee, Spencer H. Wang, Thomas B. Nutman, TT MacDonald, W He, Y Benomar, YY Hsieh   +70 more
core   +14 more sources