Results 11 to 20 of about 557,652 (221)

Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair. [PDF]

PLoS Pathogens, 2015
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection.
Julia Esser-von Bieren, Beatrice Volpe, Duncan B Sutherland, Jérôme Bürgi, J Sjef Verbeek, Benjamin J Marsland, Joseph F Urban, Nicola L Harris   +7 more
doaj   +12 more sources

Antibodies and IL-3 support helminth-induced basophil expansion [PDF]

Proceedings of the National Academy of Sciences, 2012
Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknown.
Herbst, Tina, Esser, Julia, Prati, Moira, Kulagin, Manuel, Stettler, Rebecca, Zaiss, Mario M, Hewitson, James P, Merky, Patrick, Verbeek, Joseph S, Bourquin, Carole, Camberis, Mali, Prout, Melanie, Maizels, Rick M, Le Gros, Graham, Harris, Nicola L   +14 more
core   +10 more sources

Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection [PDF]

Cell Host & Microbe, 2008
Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes chronic infection.
McCoy, K. D., Stoel, M., Stettler, R., Merky, P., Fink, K., Senn, B. M., Schaer, C., Massacand, J., Odermatt, B., Oettgen, H. C., Zinkernagel, R. M., Bos, N. A., Hengartner, H., Macpherson, A. J., Harris, N. L.   +14 more
core   +9 more sources

Broad specificity of immune helminth scFv library to identify monoclonal antibodies targeting Strongyloides [PDF]

Scientific Reports, 2021
Antibodies have different chemical properties capable of targeting a diverse nature of antigens. Traditionally, immune antibody libraries are perceived to be disease-specific with a skewed repertoire.
Anizah Rahumatullah, Dinesh Balachandra, Rahmah Noordin, Zamrina Baharudeen, Yee Ying Lim, Yee Siew Choong, Theam Soon Lim   +6 more
doaj   +4 more sources

Impact of helminth co-infection and treatment on mycobacterial growth inhibition in UK migrants with TB infection [PDF]

IJTLD Open
BACKGROUND: TB and helminth infections are co-endemic in many parts of the world. This has led to the hypothesis that immunomodulation due to helminth infections could adversely affect the ability to control Mycobacterium tuberculosis infection.
S. Anwar, C.F. Turienzo, L. Tsang, S.G. Smith, H. Fletcher, F. Toulza, J.M. Cliff, M. Brown, H.M. Dockrell   +8 more
doaj   +2 more sources

Helminth-infected Mozambican children with malaria have increased anaemia, cytokines and helminth-specific antibodies. [PDF]

PLoS Negl Trop Dis
Owing to their overlapping geographical distribution and the consequent occurrence of coinfections, several studies have evaluated the impact of helminth infections on malaria immune responses and clinical outcomes. However, little has been reported on how malaria coinfection affects anthelmintic responses in children harbouring ...
Cuamba I, Santano R, Grau-Pujol B, Vidal M, Cossa A, Jairoce C, Mejía R, Muñoz J, Aguilar R, Zhan B, Nhabomba A, Moncunill G, Dobaño C.   +12 more
europepmc   +2 more sources

Serodiagnosis of Human Strongyloidiasis in Brazil and Peru Using Strongyloides venezuelensis Antigens: A Comparative Study in Endemic Settings. [PDF]

Parasite Immunol
ABSTRACT Strongyloidiasis is a neglected tropical disease caused by the soil‐transmitted helminth Strongyloides stercoralis. Immunological assays employing heterologous antigens from Strongyloides venezuelensis represent a valuable alternative to parasitological diagnosis.
Roldán WH, Corral MA, Meisel DMCL, Canales M, Terashima MA, Lourenço SV, Gryschek RCB, de Paula FM.   +7 more
europepmc   +2 more sources

Maternally derived anti-helminth antibodies predict offspring survival in a wild mammal [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2020
The transfer of antibodies from mother to offspring provides crucial protection against infection to offspring during early life in humans and domestic and laboratory animals. However, few studies have tested the consequences of variation in maternal antibody transfer for offspring fitness in the wild.
Alexandra M. Sparks, Adam D. Hayward, Kathryn Watt, Jill G. Pilkington, Josephine M. Pemberton, Susan E. Johnston, Tom N. McNeilly, Daniel H. Nussey   +7 more
openaire   +5 more sources

Vaccination With Trichuris muris Poly-Cysteine and Histidine-Tailed Protein p43 Protects Against Chronic Infection. [PDF]

Parasite Immunol
ABSTRACT Trichuris trichiura is one of the soil transmitted geohelminths which together currently affect approximately 25% of the global population resulting in considerable morbidity particularly in children and young adults. Recent estimates put infection by T. trichiura at approximately 513 million.
Bancroft AJ, Hayes KS, Campbell L, Thompson S, Dold C, Blackwell L, Rollier CS, Thornton DJ, Grencis RK.   +8 more
europepmc   +2 more sources

From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease. [PDF]

Clin Exp Allergy
Clinical &Experimental Allergy, Volume 56, Issue 10, Page 1267-1269, October 2026.
da Conceição de Andrade JC, da Silva ES, Sousa JEA, Souza JLFM, Orrico-Ferreira CM, Souza LM, Silva RC, Dos Santos SLB, Fernandes AMS, Rios JVB, Cruz PEO, Melo VLM, de Andrade Belitardo EMM, Pacheco LGC, Pinheiro CS.   +14 more
europepmc   +2 more sources