Results 1 to 10 of about 12,131 (137)

Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection. [PDF]

Parasite Immunol
ABSTRACT The IL‐33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL‐33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation; however, the role of IL‐33‐driven mast cell responses in helminth infection is poorly understood.
Ong NWP, Hodge SH, Baker CP, Smyth DJ, Frangova T, McSorley HJ.   +5 more
europepmc   +2 more sources

Maternally derived anti-helminth antibodies predict offspring survival in a wild mammal [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2020
The transfer of antibodies from mother to offspring provides crucial protection against infection to offspring during early life in humans and domestic and laboratory animals. However, few studies have tested the consequences of variation in maternal antibody transfer for offspring fitness in the wild.
Alexandra M. Sparks, Adam D. Hayward, Kathryn Watt, Jill G. Pilkington, Josephine M. Pemberton, Susan E. Johnston, Tom N. McNeilly, Daniel H. Nussey   +7 more
openaire   +5 more sources

Antibodies and IL-3 support helminth-induced basophil expansion [PDF]

Proceedings of the National Academy of Sciences, 2012
Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknown.
Herbst Tina, Esser Julia, Prati Moira, Kulagin Manuel, Stettler Rebecca, Zaiss Mario M, Hewitson James P, Merky Patrick, Verbeek Joseph S, Bourquin Carole, Camberis Mali, Prout Melanie, Maizels Rick M, Le Gros Graham, Harris Nicola L   +14 more
openaire   +6 more sources

Broad specificity of immune helminth scFv library to identify monoclonal antibodies targeting Strongyloides [PDF]

Scientific Reports, 2021
AbstractAntibodies have different chemical properties capable of targeting a diverse nature of antigens. Traditionally, immune antibody libraries are perceived to be disease-specific with a skewed repertoire. The complexity during the generation of a combinatorial antibody library allows for a skewed but diverse repertoire to be generated ...
Anizah Rahumatullah, Dinesh Balachandra, Rahmah Noordin, Zamrina Baharudeen, Yee Ying Lim, Yee Siew Choong, Theam Soon Lim   +6 more
openaire   +4 more sources

Antibody-Based Protective Immunity against Helminth Infections: Antibody Phage Display Derived Antibodies against BmR1 Antigen [PDF]

International Journal of Molecular Sciences, 2017
Helminth parasite infections are significantly impacting global health, with more than two billion infections worldwide with a high morbidity rate. The complex life cycle of the nematodes has made host immune response studies against these parasites extremely difficult.
Anizah Rahumatullah, Izzati Abdul Karim, Rahmah Noordin, Theam Lim   +3 more
openaire   +2 more sources

Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection [PDF]

Cell Host & Microbe, 2008
Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes chronic infection.
McCoy, Kathy D., Stoel, Maaike, Stettler, Rebecca, Merky, Patrick, Fink, Katja, Senn, Beatrice M., Schaer, Corinne, Massacand, Joanna, Oderrnatt, Bernhard, Oettgen, Hans C., Zinkernagel, Rolf M., Bos, Nicolaas A., Hengartner, Hans, Macpherson, Andrew J., Harris, Nicola L.   +14 more
openaire   +3 more sources

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I [PDF]

The Journal of Immunology, 2015
Abstract Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimicked by anti-helminth vaccines ...
Esser-von Bieren J, Volpe B, Kulagin M, Sutherland DB, Guiet R, Seitz A, Marsland BJ, Verbeek JS, Harris NL   +8 more
openaire   +3 more sources

Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique [PDF]

PLOS Neglected Tropical Diseases, 2022
Background Soil-transmitted helminths (STH), Schistosoma spp. and Plasmodium falciparum are parasites of major public health importance and co-endemic in many sub-Saharan African countries.
Rebeca Santano, Rocío Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocência Cuamba, Marta Vidal, Gemma Ruiz-Olalla, Ruth Aguilar, Javier Gandasegui, Maria Demontis, Jose Carlos Jamine, Anélsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E. Chitnis, Ross L Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Lisette van Lieshout, Bin Zhan, José Muñoz, Carlota Dobaño, Gemma Moncunill   +26 more
openaire   +6 more sources

IgG Antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2012
The immune response expressed by IgG antibodies in BALB/c mice experimentally infected with Toxocara canis, was studied with the aim of verifying the possible in vivo cross-reactivity between antigens of T. canis and other parasites (Ascaris suum, Taenia crassiceps, Schistosoma mansoni, Strongyloides venezuelensis and Toxoplasma gondii).
Lescano, Susana A. Zevallos, Nakhle, Maria Cristina, Ribeiro, Manoel Carlos S.A., Chieffi, Pedro Paulo   +3 more
openaire   +5 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source