Results 41 to 50 of about 23,804 (223)

Helminth exposure and immune response to the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen.

PLoS Neglected Tropical Diseases
BackgroundThe exposure to parasites may influence the immune response to vaccines in endemic African countries. In this study, we aimed to assess the association between helminth exposure to the most prevalent parasitic infections, schistosomiasis, soil ...
Houreratou Barry, Edouard Lhomme, Mathieu Surénaud, Moumini Nouctara, Cynthia Robinson, Viki Bockstal, Innocent Valea, Serge Somda, Halidou Tinto, Nicolas Meda, Brian Greenwood, Rodolphe Thiébaut, Christine Lacabaratz   +12 more
doaj   +1 more source

Effect of maternal Schistosoma mansoni infection and praziquantel treatment during pregnancy on Schistosoma mansoni infection and immune responsiveness among offspring at age five years. [PDF]

, 2013
INTRODUCTION: Offspring of Schistosoma mansoni-infected women in schistosomiasis-endemic areas may be sensitised in-utero. This may influence their immune responsiveness to schistosome infection and schistosomiasis-associated morbidity.
AG Ross, Alison M. Elliott, AM Elliott, AM Elliott, CL King, CW Naus, David W. Dunne, DW Dunne, EJ Pearce, Emily L. Webb, FG Abath, Frances M. Jones, HE Allen, HM Coutinho, HM Coutinho, I Malhotra, I Malhotra, I Malhotra, J Utzinger, J. Russell Stothard, JC Sousa-Figueiredo, JF Friedman, JR Stothard, JR Verani, JT Scott, K Broen, LFA Oliveira, M Booth, M Brown, M Hesse, MA Montesano, MA Montesano, MI Araujo, MS Wilson, Patrice A. Mawa, Peter Naniima, R Correa-Oliveira, R Tweyongyere, R Tweyongyere, R Tweyongyere, RE Weir, RM Maizels, RM Maizels, Robert Tweyongyere, S Joseph, S Joseph, S Wilson, SE Odogwu, SJ Jenkins, Stephen Cose   +49 more
core   +2 more sources

Concomitant influence of helminth infection and landscape on the distribution of Puumala hantavirus in its reservoir, Myodes glareolus

BMC Microbiology, 2011
Background Puumala virus, the agent of nephropathia epidemica (NE), is the most prevalent hantavirus in Europe. The risk for human infection seems to be strongly correlated with the prevalence of Puumala virus (PUUV) in populations of its reservoir host ...
Henttonen Heikki, Voutilainen Liina, Sironen Tarja, Poulle Marie-Lazarine, Cadet Patrice, Chaval Yannick, Xuéreb Anne, Guivier Emmanuel, Salvador Alexis, Cosson Jean-François, Charbonnel Nathalie   +10 more
doaj   +1 more source

Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis

Microbiome, 2021
Background Studies on the inhibition of inflammation by infection with helminth parasites have, until recently, overlooked a key determinant of health: the gut microbiota.
Adam Shute, Blanca E. Callejas, ShuHua Li, Arthur Wang, Timothy S. Jayme, Christina Ohland, Ian A. Lewis, Brian T. Layden, André G. Buret, Derek M. McKay   +9 more
doaj   +1 more source

Immunological interactions between 2 common pathogens, Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica.

PLoS ONE, 2009
BackgroundThe nature of the immune response to infection is dependent on the type of infecting organism. Intracellular organisms such as Toxoplasma gondii stimulate a Th1-driven response associated with production of IL-12, IFN-gamma, nitric oxide and ...
Catherine M D Miller, Nicholas C Smith, Rowan J Ikin, Nicola R Boulter, John P Dalton, Sheila Donnelly   +5 more
doaj   +1 more source

Human Schistosome Infection and Allergic Sensitisation [PDF]

, 2012
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Mutapi, Francisca, Rujeni, Nadine, Taylor, David W.   +2 more
core   +3 more sources

Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads. [PDF]

PLoS Neglected Tropical Diseases, 2016
Worldwide more than 2 billion people are infected with helminths, predominantly in developing countries. Co-infections with viruses such as human immunodeficiency virus (HIV) are common due to the geographical overlap of these pathogens.
Kirsten Katrin Dietze, Ulf Dittmer, Daniel Karim Koudaimi, Simone Schimmer, Martina Reitz, Minka Breloer, Wiebke Hartmann   +6 more
doaj   +1 more source

Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis [PDF]

, 2014
Parasitic worms are able to survive in their mammalian host for many years due to their ability to manipulate the immune response by secreting immunomodulatory products. It is increasingly clear that, reflecting the anti-inflammatory actions of such worm-
Al-Riyami, L., Harnett, M. M., Harnett, W., Pineda, M. A.   +3 more
core   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2013
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M, Smith, Katherine A
core   +2 more sources