Results 61 to 70 of about 557,652 (221)

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]

, 2009
Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
core   +2 more sources

Efficacy of an enzyme-linked immunosorbent assay as a diagnostic tool for schistosomiasis mansoni in individuals with low worm burden

Memorias do Instituto Oswaldo Cruz, 2005
IgM-ELISA is an immunoenzymatic method useful for detection of IgM antibodies against a fraction of Schistosoma mansoni adult worm antigen (AWA) that is soluble in trichloroacetic acid (AWA-TCA).
Edward José de Oliveira, Hermínia Yohko Kanamura, Dirce Mary Correia Lima   +2 more
doaj   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19

Vaccines
Background/Objectives: The COVID-19 pandemic has significantly impacted global health. However, Africa has reported relatively low numbers of cases and fatalities.
Brice Armel Nembot Fogang, Julia Meyer, Linda B. Debrah, Michael Owusu, George Agyei, Derrick Adu Mensah, John Boateng, Jubin Osei Mensah, Ute Klarmann-Schulz, Sacha Horn, Inge Kroidl, Ezekiel Bonwin Ackah, Richard O. Phillips, Augustina Sylverken, Alexander Y. Debrah, Achim Hoerauf, Tomabu Adjobimey   +16 more
doaj   +1 more source

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Cell Reports, 2016
Summary: Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be
Lalit Kumar Dubey, Luc Lebon, Ilaria Mosconi, Chen-Ying Yang, Elke Scandella, Burkhard Ludewig, Sanjiv A. Luther, Nicola L. Harris   +7 more
doaj   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Transmission of helminth eggs through hands in a high-risk community.

, 2014
BACKGROUND: The role that hands play in the transmission of Ascaris is not well understood. METHODS: A newly developed method to quantify the presence helminth eggs on hands was tested among a group of farmers in Vietnam.
Do, Hong Anh, Ensink, Jeroen HJ, Jeandron, Aurelie, Nguyen, Viet Anh, Gulliver, Francesca   +4 more
core   +1 more source

Sustainable control of cyathostomin infections in practice

Equine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. [PDF]

, 2012
BACKGROUND: Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia ...
Cruz, Álvaro Augusto, Pontes-de-Carvalho, Lain Carlos, Cruz Álvaro Augusto, Rodrigues, LC, Santos, J, Rosemeire Fiaccone, Dattoli Vitor Camilo Cavalcante, Fiaccone, Rosemeire Leovigildo, Pontes-de-Carvalho Lain Carlos, Rodrigues Laura Cunha, Barreto Maurício Lima, Figueiredo, CA, Barreto, Maurício Lima, Mendonça, Lívia Ribeiro, Philip John Cooper, Lívia Ribeiro Mendonça, Figueiredo Camila Alexandrina, Figueiredo, Camila Alexandrina, Pontes-de-Carvalho, LC, Fiaccone, R, Rafael Valente Veiga, Alcantara-Neves Neuza Maria, Alcantara-Neves, NM, Veiga, Rafael Valente, Cooper, PJ, Cooper, Philip, Laura Cunha Rodrigues, Dattoli, Vitor Camilo Cavalcante, Fiaccone, Rosemeire, Dattoli, VC, Jackson Santos, Cooper Philip John, Lain Carlos Pontes-de-Carvalho, Santos Jackson, Alcantara-Neves, Neuza Maria, Mendonça Lívia Ribeiro, Santos, Jackson, Cooper, Philip John, Neves, Neuza Maria Alcântara, Veiga Rafael Valente, Camila Alexandrina Figueiredo, Cruz, ÁA, Barreto, ML, Figueiredo, Camila Alexandrina Viana, Vitor Camilo Cavalcante Dattoli, Neuza Maria Alcantara-Neves, Fiaccone Rosemeire, Álvaro Augusto Cruz, Maurício Lima Barreto, Veiga, RV, Rodrigues, Laura Cunha, Mendonça, LR, Cruz Filho, Alvaro Augusto Souza da   +52 more
core   +1 more source