Results 161 to 170 of about 56,276 (247)

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis. [PDF]

open access: yesNat Commun
Kanno A   +38 more
europepmc   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

open access: yesCancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap   +16 more
wiley   +1 more source

T-Cell-Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS-CoV-2 Infection. [PDF]

open access: yesAdv Sci (Weinh)
Fu W   +8 more
europepmc   +1 more source

Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 74-79, July 2025.
Oncology dose optimization during the era of chemotherapy focused on identifying the maximum tolerated dose (MTD) for registrational trials, often resulting in significant toxicity. The advent of molecular targeted drugs and immunotherapies offers the potential to achieve similar efficacy with lower doses and fewer side effects, as maximal efficacy is ...
Jiawen Zhu   +12 more
wiley   +1 more source

TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions

open access: yesHematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese   +11 more
wiley   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song   +9 more
wiley   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

open access: yesChemBioChem, Volume 26, Issue 11, June 3, 2025.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl   +7 more
wiley   +1 more source

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