Results 161 to 170 of about 169,027 (313)

Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer: A multi‐center real‐world study

iMeta, EarlyView.
In this study, 102 cisplatin‐ineligible patients with muscle‐invasive bladder cancer (MIBC) who received neoadjuvant RC48‐ADC combined with immunotherapy were included. We evaluated the pathological responses and explored multiple clinical characteristics to identify independent predictive indicators of the efficacy. The results showed that neoadjuvant
Jiao Hu, Luzhe Yan, Jinhui Liu, Minfeng Chen, Peihua Liu, Dingshan Deng, Chaobin Zhang, Yunbo He, Benyi Fan, Huihuang Li, Guanghui Gong, Jiatong Xiao, Ruizhe Wang, Xiao Guan, Shiyu Tong, Yangle Li, Nannan Li, Zhiwang Tang, Teng Zhang, Hao Li, Bin Huang, Ning Gao, Wei He, Zhiyong Cai, Yifan Liu, Zefu Liu, Yu Gan, Yu Cui, Yuanqing Dai, Yi Cai, Zhenyu Nie, Zhenyu Ou, Jinbo Chen, Xiongbing Zu   +33 more
wiley   +1 more source

From simplicity to complexity in current melanoma models

Experimental Dermatology, Volume 31, Issue 12, Page 1818-1836, December 2022., 2022
Abstract Despite the recent impressive clinical success of immunotherapy against melanoma, development of primary and adaptive resistance against immune checkpoint inhibitors remains a major issue in a large number of treated patients. This highlights the need for melanoma models that replicate the tumor's intricate dynamics in the tumor ...
Elisabetta Michielon, Tanja D. de Gruijl, Susan Gibbs   +2 more
wiley   +1 more source

Hyperbox Mixture Regression for Process Performance Prediction in Antibody Production [PDF]

arXiv
This paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data's complexity and high dimensionality.
arxiv  

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

The use of immunoglobulins and monoclonal antibodies against COVID-19

Вопросы вирусологии
Introduction. When a new disease occurs, one of the most affordable remedies is drugs containing specific antibodies to this infectious agent. The use of such drugs is aimed at reducing the amount of the pathogen in the macroorganism and the associated ...
Elena E. Popadyuk, Tatyana E. Sizikova, Aleksey L. Khmelev, Mikhail A. Timofeev, Vitaliy N. Lebedev, Sergey V. Borisevich   +5 more
doaj   +1 more source

Research progress of antibody coupling technique in targeted drug delivery

Interdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li, Tiantian Wang, Dan Tan, Mengqi Wang, Changhai Lei, Yuqing Wang, Shi Hu   +6 more
wiley   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine

Interdisciplinary Medicine, EarlyView.
Novel biomarker emergence plays a critical role in improving CHB management. Advances in sensitive detection methods, AI, and large‐scale data platforms have independently contributed to biomarkers while driving the development of multi‐omics approaches.
Yaru Shi, Rong Fan
wiley   +1 more source

Pharmacokinetic and Exposure–Response Modeling Support Body Surface Area‐Based Dosing of Farletuzumab Ecteribulin in Japanese Patients with Solid Tumors

The Journal of Clinical Pharmacology, EarlyView.
Abstract The first‐in‐human, Phase 1 Study 101 showed antitumor activity and a tolerable safety profile of farletuzumab ecteribulin in Japanese patients with platinum‐resistant ovarian and non‐small cell lung cancer. A pharmacometric assessment evaluated farletuzumab ecteribulin pharmacokinetics and exposure–response (E‐R) relationships for efficacy ...
Seiichi Hayato, Lora Hamuro, Toshio Shimizu, Kan Yonemori, Shin Nishio, Mayu Yunokawa, Tatsuya Yoshida, Makoto Nishio, Koji Matsumoto, Kazuhiro Takehara, Kosei Hasegawa, Toshiyuki Kozuki, Yasuyuki Hirashima, Hidenori Kato, Takuma Miura, Maiko Nomoto, Yue Zhao, Li Zhu, Sanae Yasuda   +18 more
wiley   +1 more source

Unraveling Alzheimer’s: the promise of aducanumab, lecanemab, and donanemab

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Alzheimer’s disease (AD) is a neurodegenerative condition that causes cognitive decline, memory loss, and reduced personal autonomy. The pathology of AD involves the aggregation of abnormal brain proteins, specifically beta-amyloid plaques and tau ...
Taha Basit Ameen, Syeda Naveera Kashif, Syed Muhammad Iraj Abbas, Kulsoom Babar, Syed Muhammad Sinaan Ali, Abdul Raheem   +5 more
doaj   +1 more source