Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis. [PDF]
Kanno A+38 more
europepmc +1 more source
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap+16 more
wiley +1 more source
T-Cell-Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS-CoV-2 Infection. [PDF]
Fu W+8 more
europepmc +1 more source
Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes
Oncology dose optimization during the era of chemotherapy focused on identifying the maximum tolerated dose (MTD) for registrational trials, often resulting in significant toxicity. The advent of molecular targeted drugs and immunotherapies offers the potential to achieve similar efficacy with lower doses and fewer side effects, as maximal efficacy is ...
Jiawen Zhu+12 more
wiley +1 more source
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases. [PDF]
Yin T+4 more
europepmc +1 more source
TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese+11 more
wiley +1 more source
Development of Antibody-Drug Conjugates for Malignancies of the Uterine Corpus: A Review. [PDF]
Yamanaka T, Nishikawa T, Yoshida H.
europepmc +1 more source
Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song+9 more
wiley +1 more source
Antitumor Activities of a Humanized Cancer-Specific Anti-HER2 Monoclonal Antibody, humH<sub>2</sub>Mab-250 in Human Breast Cancer Xenografts. [PDF]
Kaneko MK+6 more
europepmc +1 more source
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl+7 more
wiley +1 more source