Results 271 to 280 of about 169,027 (313)

Human monoclonal antibodies

Molecular and Cellular Biochemistry, 1984
The technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described.
D. Kozbor, T. Atlaw, Susan P.C. Cole, B. G. Campling, J. C. Roder   +4 more
openaire   +6 more sources

A human monoclonal antibody to insulin

Diabetes, 1986
To elucidate the immune aspects of insulin-dependent diabetes mellitus (IDDM), we attempted to generate human monoclonal anti-insulin antibodies by fusing peripheral blood lymphocytes obtained from 10 insulin-treated IDDM patients with cells from a human lymphoblastoid cell line. Hybridomas that secreted immunoglobulins appeared in 9 of 400 wells.
Avi Livneh, Irun R. Cohen, Hava Avraham, Joseph Sack, Dana Elias, Zelig Eshhar   +5 more
openaire   +3 more sources

Monoclonal antibodies to human casein

Molecular Immunology, 1985
Two monoclonal antibodies, LICR-LON-32.2 (32.2) and LICR-LON-14.1 (14.1), are described which react with human casein. 32.2 reacts with human beta-casein and 14.1 with human kappa-casein. 32.2 also reacts with rat band 2 casein and bovine beta-casein, but 14.1 appears to be specific for human kappa-casein. These monoclonal antibodies do not cross-react
R.A.J. McIlhinney, Helena M. Earl
openaire   +3 more sources

Monoclonal Antibody to Human Cytotrophoblast

American Journal of Reproductive Immunology, 1984
ABSTRACT: A monoclonal antibody (18B/A5) has been generated against human first trimester trophoblast membranes which, unlike others so far reported in the literature, reacted only with cytotrophoblast and not with syncytiotrophoblast. Although the identity of the target antigen has not yet been established, the antibody could be a valuable tool for ...
Susan Day, Yung Wai Loke
openaire   +3 more sources

Monoclonal antibodies to human amnion

Journal of Reproductive Immunology, 1986
Mouse hybridoma cell lines secreting monoclonal antibodies to human amnion were established. The reactivities of eight of these monoclonal antibodies (GB1, GB3, GB4, GB5, GB6, GB9, GB10 and GB11) on human skin and term extra-embryonic tissues, which included reflected amniochorions, basal plates, placentae, chorionic plates and umbilical cords, are ...
Chang-Jing G. Yeh, Bae-Li Hsi
openaire   +3 more sources

Monoclonal Antibody to Human Thyrotropin*

The Journal of Clinical Endocrinology & Metabolism, 1982
Using the technique of somatic cell fusion, a monoclonal antibody to human TSH (hTSH) has been produced. The monoclonal antibody (anti-hTSH 1/1) has an affinity (Kd = 4.04 x 10(-9) M/liter) for hTSH which is slightly less than that of the polyclonal antisera (Kd = 9.8 x 10(-10) M/liter) derived from the same mouse used for the fusion experiment.
Ridgway, E C, Ardisson, L J, Meskell, M J, Mudgett, hunter M   +3 more
openaire   +3 more sources

[5] Humanization of monoclonal antibodies

1991
Publisher Summary This chapter describes the humanization of the murine monoclonal antibody BW431/26 that has binding specificity for carcinoembryonic antigen (CEA) and is presently used as murine monoclonal antibodies (MAbs) for the immunoscintigraphy of CEA-producing tumors, such as colorectal, breast, and lung carcinomas.
Detlef Güssow, Gerhard Seemann
openaire   +3 more sources

Generating human monoclonal antibodies

Medical Oncology and Tumor Pharmacotherapy, 1984
Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may ...
P. A. W. Edwards, M. J. O'Hare, A. M. Neville   +2 more
openaire   +3 more sources

Human and chimpanzee monoclonal antibodies

Journal of Immunological Methods, 1985
Monoclonal antibody-secreting cell lines were isolated after transformation of peripheral blood leukocytes with Epstein-Barr virus. Blood samples were obtained from human donors having circulating antibodies against hepatitis viruses (HAB, HBV), rubella, or rabies virus and from a chimpanzee infected with HAV. Dextran-isolated leukocytes were submitted
F.C.M. van Meel, J.C.H. Oomen, Peter G. A. Steenbakkers   +2 more
openaire   +3 more sources