Results 281 to 290 of about 169,027 (313)
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Immunology Today, 1988
Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Monoclonal Antibodies to Human Nephrin
Hybridoma and Hybridomics, 2004Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Paula Reponen +4 more
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Monoclonal Antibodies to Human Choriocarcinoma
American Journal of Reproductive Immunology and Microbiology, 1986ABSTRACT: We have established two monoclonal antibodies (TM7‐3 and TM3‐8) that react to choriocarcinoma cells. Both of these monoclonal antibodies have shown a similar reactive pattern to human cell lines, normal and neoplastic trophoblast tissues, and other fetal and adult tissues.
Yamashita K +3 more
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Monoclonal antibodies to human erythrocytes
European Journal of Immunology, 1982AbstractEight monoclonal antibodies from mouse hybridomas raised to normal human erythrocytes were tested with a panel of null‐type erythrocytes, enzyme‐treated normal cells, and by inhibition with human erythrocyte sialoglycoproteins. Two antibodies reacted poorly or not at all with RhNULL cells.
D J Anstee, P. A. W. Edwards
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Human Monoclonal Antibodies to Human Cytomegalovirus
The Journal of Infectious Diseases, 1989Human monoclonal antibodies (HMAbs) to human cytomegalovirus (HCMV) have been developed by using electric field-induced cell fusion of human B lymphocytes to the human-mouse cell line SBC-H20. By this procedure, multiple hybridomas have been produced that secrete IgG 1 HMAbs with distinct patterns of indirect immunofluorescence on HCMV-infected cells ...
Judy Rowe +6 more
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1985
The monoclonal antibody technology has had a major impact on the serological and biochemical analysis of human tumor antigens. Monoclonal antibodies have rapidly led to the identification and characterization of a large number of antigenic determinants on cancer cells.
Alan N. Houghton, Richard J. Cote
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The monoclonal antibody technology has had a major impact on the serological and biochemical analysis of human tumor antigens. Monoclonal antibodies have rapidly led to the identification and characterization of a large number of antigenic determinants on cancer cells.
Alan N. Houghton, Richard J. Cote
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Monoclonal antibodies against human chondrocytes
In Vitro Cellular & Developmental Biology - Animal, 1996Cell-specific antigens are mainly found in cells or membrane surfaces rather than in the surrounding matrix. However, until now it was not possible to produce antibodies specific for cellular structures of chondrocytes. In 1989, Lance (Immunol. Lett.
Bujia, J. +6 more
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Monoclonal antibodies and therapy of human cancers
Biotechnology Advances, 2000This survey is an overview of the applications of murine, humanized and recombinant monoclonal antibodies for in vivo diagnostic and therapeutic applications. Monoclonal antibodies (mAb) have been applied to the diagnosis and therapy of an array of human diseases.
FUNARO, Ada +5 more
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An inhibitory monoclonal antibody to human acetylcholinesterases
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987The monoclonal antibody AE-2 raised against acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) from human erythrocytes is shown to inhibit the enzyme activity. The reaction of the antibody with a structural epitope is investigated further. The epitope resides on monomeric, dimeric and tetrameric species of the enzyme.
Sorensen, K +3 more
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Humanization of Monoclonal Antibodies
1994Antibodies of predefined specificity have many potential uses in human therapy and diagnosis, and hybridoma technology (Koehler and Milstein 1975) has made possible the generation of virtually limitless amounts of such antibodies. Unfortunately, hybridoma proteins are more easily obtained from nonhuman, usually rodent, sources and the use of those ...
G. E. Mark, E. A. Padlan
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