Results 281 to 290 of about 405,156 (331)
Some of the next articles are maybe not open access.
Monoclonal antibodies to human amnion
Journal of Reproductive Immunology, 1986Mouse hybridoma cell lines secreting monoclonal antibodies to human amnion were established. The reactivities of eight of these monoclonal antibodies (GB1, GB3, GB4, GB5, GB6, GB9, GB10 and GB11) on human skin and term extra-embryonic tissues, which included reflected amniochorions, basal plates, placentae, chorionic plates and umbilical cords, are ...
Chang-Jing G. Yeh, Bae-Li Hsi
openaire +3 more sources
[5] Humanization of monoclonal antibodies
1991Publisher Summary This chapter describes the humanization of the murine monoclonal antibody BW431/26 that has binding specificity for carcinoembryonic antigen (CEA) and is presently used as murine monoclonal antibodies (MAbs) for the immunoscintigraphy of CEA-producing tumors, such as colorectal, breast, and lung carcinomas.
Detlef Güssow, Gerhard Seemann
openaire +3 more sources
Monoclonal Antibody to Human Thyrotropin*
The Journal of Clinical Endocrinology & Metabolism, 1982Using the technique of somatic cell fusion, a monoclonal antibody to human TSH (hTSH) has been produced. The monoclonal antibody (anti-hTSH 1/1) has an affinity (Kd = 4.04 x 10(-9) M/liter) for hTSH which is slightly less than that of the polyclonal antisera (Kd = 9.8 x 10(-10) M/liter) derived from the same mouse used for the fusion experiment.
Ridgway, E C +3 more
openaire +3 more sources
Generating human monoclonal antibodies
Medical Oncology and Tumor Pharmacotherapy, 1984Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may ...
P. A. W. Edwards +2 more
openaire +3 more sources
Monoclonal Antibodies: A Review.
Current Clinical Pharmacology, 2017BACKGROUND Over the last three decades, monoclonal antibodies (MAbs) have made a striking transformation from scientific tools to powerful human therapeutics.
Surjit Singh +6 more
semanticscholar +1 more source
Human and chimpanzee monoclonal antibodies
Journal of Immunological Methods, 1985Monoclonal antibody-secreting cell lines were isolated after transformation of peripheral blood leukocytes with Epstein-Barr virus. Blood samples were obtained from human donors having circulating antibodies against hepatitis viruses (HAB, HBV), rubella, or rabies virus and from a chimpanzee infected with HAV. Dextran-isolated leukocytes were submitted
F.C.M. van Meel +2 more
openaire +3 more sources
Immunology Today, 1988
Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
openaire +3 more sources
Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
openaire +3 more sources
Monoclonal Antibodies to Human Nephrin
Hybridoma and Hybridomics, 2004Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Paula Reponen +4 more
openaire +2 more sources
Monoclonal Antibodies to Human Choriocarcinoma
American Journal of Reproductive Immunology and Microbiology, 1986ABSTRACT: We have established two monoclonal antibodies (TM7‐3 and TM3‐8) that react to choriocarcinoma cells. Both of these monoclonal antibodies have shown a similar reactive pattern to human cell lines, normal and neoplastic trophoblast tissues, and other fetal and adult tissues.
Yamashita K +3 more
openaire +3 more sources
Monoclonal antibodies to human erythrocytes
European Journal of Immunology, 1982AbstractEight monoclonal antibodies from mouse hybridomas raised to normal human erythrocytes were tested with a panel of null‐type erythrocytes, enzyme‐treated normal cells, and by inhibition with human erythrocyte sialoglycoproteins. Two antibodies reacted poorly or not at all with RhNULL cells.
D J Anstee, P. A. W. Edwards
openaire +3 more sources