Results 291 to 300 of about 169,027 (313)

A Human Monoclonal Antibody to rh^G

Vox Sanguinis, 1986
Abstract. Hybridomas secreting a human monoclonal IgG1 antibody against a variant of the rhG antigen were produced from B lymphocytes of an Rh‐negative donor with serum antibodies to D and C antigens. The antibody reacts by indirect hemagglutination with nearly all C‐ or D‐positive cells, confirming the strong association in the expression of G with D
Susan Perkins, F. Carl Grumet, Linda Winn, Steven K. H. Foung, Judy Blunt   +4 more
openaire   +3 more sources

Humanization and Simultaneous Optimization of Monoclonal Antibody

2013
Antibody humanization is an essential technology for reducing the potential risk of immunogenicity associated with animal-derived antibodies and has been applied to a majority of the therapeutic antibodies on the market. For developing an antibody molecule as a pharmaceutical at the current biotechnology level, however, other properties also have to be
Hiroyuki Tsunoda, Tomoyuki Igawa, Kunihiro Hattori, Taichi Kuramochi   +3 more
openaire   +4 more sources

Human monoclonal macroglobulins with antibody activity

Seminars in Oncology, 2003
Assays for specific antigen-binding activity were performed on sera from 172 patients with monoclonal macroglobulinemia defined by immunofixation electrophoresis. The sera were collected between 1970 and 2002. Mean IgM level was 1,409 mg/dL with a range from 70 to 6,800.
Alan Pestronk, Marvin J. Stone, Janet L. Reynolds, Alex W. Tong, Yolonda G. McElroy, Joseph T. Newman   +5 more
openaire   +3 more sources

A Monoclonal Antibody for Immunopurification of Human Renin

Clinical Science, 1981
1. A mouse hybridoma secreting an antibody directed against human renin was obtained by fusion of spleen cells with NS 1 myeloma cells. This monoclonal antibody recognizes human and monkey renins but neither hog nor mouse renins nor the acid proteinase cathepsin D. 2. Monoclonal antibody was coupled to Sepharose 4 B.
Bernard Pau, F X Galen, C. Devaux, Pierre Corvol, Joël Ménard, Florent Soubrier, D Simon   +6 more
openaire   +3 more sources

Human Hybridomas and Monoclonal Antibodies

1985
In this review I will cover, from a cell biologist’s perspective, the biology of cell fusion and how the information derived from the field may be applicable to the production of human monoclonal antibodies. I will describe the development of the hybridoma technology, the advantages and disadvantages of making and using monoclonal antibodies, the ...
Edgar G. Engleman, Steven K. H. Foung, James W. Larrick, Andrew Raubitschek   +3 more
openaire   +4 more sources

Human Monoclonal Antibodies: Recent Achievements

Hospital Practice, 1994
The latest developments include an anti-HIV antibody that has 1,000 times the affinity of natural antibody and that neutralizes primary clinical isolates, and an anti-RSV antibody that reduces viral titers in mice by 12,000-fold within 24 hours.
C F Barbas rd, Dennis R. Burton
openaire   +3 more sources

Human Monoclonal Antibodies: The Benefits of Humanization

2018
The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement system and naturally occurring Fc receptors on diverse blood white cells.
openaire   +3 more sources

Monoclonal antibodies against human prostasomes

The Prostate, 1998
The prostasomes are secreted into the gland ducts of the human prostate. At ejaculation, these native prostasomes are expelled with the secretions of the prostate and appear in the seminal plasma as seminal prostasomes, where they facilitate sperm function in various ways.
Bo Nilsson, Meishan Jin, B.-E. Persson, B. Einarsson, Gunnar Ronquist   +4 more
openaire   +3 more sources

Human Monoclonal Antibody Technology [PDF]

, 1994
The success of Kohler and Milstein (1975) in immortalizing specific antibody secreting cell lines of rodent origin inevitably led to similar attempts to generate human monoclonals. Initially this effort was largely driven by the belief that such products would be clinically (especially therapeutically) superior to their rodent counterparts. In addition
openaire   +1 more source

Characterization of Monoclonal Antibodies to Human OC43

1987
Human coronaviruses are important respiratory pathogens (1). These viruses have also been implicated in human neurological diseases (2, 3), and some reports have suggested an association with the demyelinating condition multiple sclerosis (4, 5, 6), although other studies cast doubt upon the role of coronaviruses in this disease (7, 8, 9, 10, 11).
Stephen A. Stohlman, Theodore Wei, James G. Keck, John O. Fleming, N. J. Kachuck   +4 more
openaire   +3 more sources