Results 141 to 150 of about 2,105,900 (288)

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Development of an In-House Antigen ELISA Using Monoclonal and Polyclonal Antibodies Against an Isolated Canine Distemper Virus. [PDF]

Vet Med Sci
Kökkaya S, Göksu AG.
europepmc   +1 more source

Antibody‐Programmable Bimetallic Nanozymes for Transcriptional Blockade Therapy in HER2/ER‐Positive Breast Cancer

Advanced Functional Materials, EarlyView.
Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao, Tong Ye, Mingjiang Liu, Jingchao Gao, Lian Tan, Qian Dong, Qingbo Lv, Qianqian Ye, Yu Wang   +8 more
wiley   +1 more source

Monoclonal Anti-Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss. [PDF]

N Engl J Med
Bavli NR, Kanack AJ, Nishimura Y, Splinter NP, Mauch EE, Ainsworth AJ, Sarode R, McBane RD, Kohlhagen MC, Murray D, Chen D, Pruthi RK, Padmanabhan A.   +12 more
europepmc   +1 more source

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

Nature, 2020
D. Pinto, Young-Jun Park, M. Beltramello, A. Walls, M. A. Tortorici, S. Bianchi, S. Jaconi, K. Culap, F. Zatta, A. De Marco, A. Peter, B. Guarino, R. Spreafico, E. Cameroni, J. Case, Rita E. Chen, C. Havenar-Daughton, G. Snell, A. Telenti, Herbert W. Virgin, A. Lanzavecchia, Michael S. Diamond, K. Fink, D. Veesler, D. Corti   +24 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Nanotechnology Approaches for Mitigating Biologic Immunogenicity: A Literature Review. [PDF]

Pharmaceutics
Alanazi J, Aleanizy FS, Alqahtani FY.
europepmc   +1 more source

Label‐Free and Low‐Power Driven Cancer Biomarker Detection Enabled by 2D Hexagonal Titanium Oxide

Advanced Functional Materials, EarlyView.
A low‐power driven FET biosensor based on 2D hexagonal TiO2 detects the cancer biomarker carcinoembryonic antigen with high sensitivity, a low detection limit of 0.22 pg mL−1, and excellent selectivity. Leveraging the unique electronic properties of the material, this work demonstrates strong potential for integration into miniature and portable cancer
Yange Luan, Qijie Ma, Yihong Hu, Xinyi Hu, Guanyu Chen, Jiaru Zhang, Zhong Li, Dongdong Xie, Guanghui Ren, Yunyi Yang, Guifu Ding, Kate Fox, Bao Yue Zhang, Jian Zhen Ou   +13 more
wiley   +1 more source

The Structural Fingerprint of Therapeutic Monoclonal Antibodies Determined Using a Combination of Near-UV Circular Dichroism and Statistical Approach for Comparative Analysis. [PDF]

Anal Chem
Kiyoshi M, Oyama T, Shibata H, Suzuki S, Higuchi Y, Tsumoto K, Ishii-Watabe A.   +6 more
europepmc   +1 more source