Results 191 to 200 of about 2,469,529 (358)

Anticuerpos monoclonales empleados como agentes terapéuticos en enfermedades inflamatorias [PDF]

, 2013
Los anticuerpos monoclonales empleados en la clínica para el tratamiento de enfermedades inflamatorias abarcan un amplio campo de trabajo cuyo entendimiento se inicia con una breve descripción de la obtención de los distintos tipos que se encuentran ...
Sanchez, Mercedes Leonor
core  

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi   +9 more
wiley   +1 more source

The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep

Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley   +1 more source

A Gym for Cells—Direct Laser Writing of Magnetic Multilayered Micro Actuators for Mechanical Stimulation of Cells

Advanced Functional Materials, EarlyView.
Surface‐attached multilayer micromagnet systems are fabricated by two‐photon crosslinking. The pillar‐shaped micro actuators consist of a soft and flexible surface‐attached cell‐repellent hydrogel layer at the bottom, acting as a hinge and a cell‐adhesive hydrophobic polymer filled with magnetic nanoparticles.
Nicolas Geid, Ayman Husari, Eleonora Galli, Lukas Leffler, Pascal Tomakidi, Jürgen Rühe   +5 more
wiley   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Bispecific antibodies: design, therapy, perspectives

Drug Design, Development and Therapy, 2018
Sergey E Sedykh, Victor V Prinz, Valentina N Buneva, Georgy A Nevinsky Laboratory of Repair Enzymes, Siberian Branch of Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, Novosibirsk State University, Novosibirsk, Russia
Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA   +3 more
doaj  

Adverse effects of monoclonal antibodies in the treatment of moderate-to-severe asthma: a narrative review

Journal of Education, Health and Sport
Introduction and purpose: Over the past two decades, the management of severe asthma shifted from high doses of inhaled and oral corticosteroids to targeted biologic agents.
Izabela Orzołek, Izabela Stawicka, Jakub Jarmołowicz, Agata Boczar, Patryk Dryja   +4 more
doaj   +1 more source

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Nature, 2021
Zijun Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. Barnes, Shlomo Finkin, Dennis J. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. Lieberman, Thiago Y. Oliveira, Zhi Yang, M. Abernathy, Kathryn E Huey-Tubman, A. Hurley, Martina Turroja, K. West, Kristie M Gordon, Katrina G. Millard, Victor Ramos, Justin Da Silva, Jianliang Xu, R. Colbert, R. Patel, Juan P Dizon, Cecille Unson-O’Brien, I. Shimeliovich, A. Gazumyan, M. Caskey, P. Bjorkman, R. Casellas, T. Hatziioannou, P. Bieniasz, M. Nussenzweig   +33 more
semanticscholar   +1 more source

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source