Results 191 to 200 of about 652,488 (245)

COVID-19 in immunocompromised patients: proposed definition of a new entity with prolonged infection. [PDF]

New Microbes New Infect
Gentile I, Schiano Moriello N, Maraolo AE, Rappuoli R.   +3 more
europepmc   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Anti-B Cell Strategy in Nephrotic Syndrome: Beyond Rituximab. [PDF]

Biomedicines
Jin Y, Xie Y, Fu H, Liu F, Mao J.
europepmc   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Dose finding in early-phase human immunodeficiency virus type 1 prevention monoclonal antibody clinical trials. [PDF]

Clin Trials
Huang Y, Zhang B, Zhang L, Mayer BT, Martin T, Hahn W, Hyrien O, Gelderblom HC.   +7 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein

Zyla DS, Marca RD, Lacarbonara D, Niemeyer G, Zipursky G, Di Clemente L, Jonathan-Trakht G, Kalantarov G, Acciani M, Laterza G, Vyshenska D, Hastie KM, Horvat B, Greninger AL, Niewiesk S, Saphire EO, Porotto M.   +16 more
europepmc   +1 more source

RSV Prevention in Infants and Young Children. [PDF]

Am J Respir Crit Care Med
Cacho F, Sockrider M.
europepmc   +1 more source

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, EarlyView.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source

Mouse monoclonal antibodies against <i>Clostridioides difficile</i> toxins TcdA and TcdB target diverse epitopes for neutralization. [PDF]

Infect Immun
Kroh HK, Jensen JL, Wellnitz S, Park JJ, Esadze A, Huynh KW, Ammirati M, Han S, Anderson AS, Lacy DB, Gribenko A.   +10 more
europepmc   +1 more source