Results 31 to 40 of about 514,317 (292)
AntiBARTy Diffusion for Property Guided Antibody Design [PDF]
arXiv, 2023 Over the past decade, antibodies have steadily grown in therapeutic importance thanks to their high specificity and low risk of adverse effects compared to other drug modalities. While traditional antibody discovery is primarily wet lab driven, the rapid improvement of ML-based generative modeling has made in-silico approaches an increasingly viable ...
arxiv
Encephalitis with mGluR5 antibodies [PDF]
Neurology, 2018 To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna +15 more
openaire +4 more sources
Frontiers in Chemistry, 2022 Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu +22 more
doaj +1 more source
Frontiers in Immunology, 2018 In spite of impressive response rates in multiple cancer types, immune checkpoint inhibitors (ICIs) are active in only a minority of patients. Alternative strategies currently aim to combine immunotherapies with conventional agents such as cytotoxic ...
Chloé Grasselly +13 more
doaj +1 more source
Mouse Models and Tools for the in vivo Study of Neutrophils
Frontiers in Immunology, 2020 Neutrophils are the most abundant leukocytes in human blood and critical actors of the immune system. Many neutrophil functions and facets of their activity in vivo were revealed by studying genetically modified mice or by tracking fluorescent ...
Julien Stackowicz +4 more
doaj +1 more source
Pharmaceutics, 2023 The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases.
Laura Rué +6 more
doaj +1 more source
xTrimoABFold: De novo Antibody Structure Prediction without MSA [PDF]
arXiv, 2022 In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function.
arxiv
State of play and clinical prospects of antibody gene transfer
Journal of Translational Medicine, 2017 Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
doaj +1 more source
Isolation methods determine human neutrophil responses after stimulation
Frontiers in Immunology, 2023 Studying neutrophils is challenging due to their limited lifespan, inability to proliferate, and resistance to genetic manipulation. Neutrophils can sense various cues, making them susceptible to activation by blood collection techniques, storage ...
Vanessa Krémer +8 more
doaj +1 more source
On Pre-trained Language Models for Antibody [PDF]
arXiv, 2023 Antibodies are vital proteins offering robust protection for the human body from pathogens. The development of general protein and antibody-specific pre-trained language models both facilitate antibody prediction tasks. However, there have been limited studies that comprehensively explore the representation capability of distinct pre-trained language ...
arxiv