Results 51 to 60 of about 3,769,586 (361)

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

Frontiers in Immunology, 2018
In spite of impressive response rates in multiple cancer types, immune checkpoint inhibitors (ICIs) are active in only a minority of patients. Alternative strategies currently aim to combine immunotherapies with conventional agents such as cytotoxic ...
Chloé Grasselly, Chloé Grasselly, Morgane Denis, Morgane Denis, Aurore Bourguignon, Aurore Bourguignon, Nolan Talhi, Doriane Mathe, Anne Tourette, Laurent Serre, Lars Petter Jordheim, Eva Laure Matera, Charles Dumontet, Charles Dumontet   +13 more
doaj   +1 more source

Mouse Models and Tools for the in vivo Study of Neutrophils

Frontiers in Immunology, 2020
Neutrophils are the most abundant leukocytes in human blood and critical actors of the immune system. Many neutrophil functions and facets of their activity in vivo were revealed by studying genetically modified mice or by tracking fluorescent ...
Julien Stackowicz, Julien Stackowicz, Friederike Jönsson, Laurent L. Reber, Laurent L. Reber   +4 more
doaj   +1 more source

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Science, 2020
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies.
Anna Z. Wec, D. Wrapp, A. Herbert, Daniel P. Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping V. Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael E. Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia M. O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker   +36 more
semanticscholar   +1 more source

Isolation methods determine human neutrophil responses after stimulation

Frontiers in Immunology, 2023
Studying neutrophils is challenging due to their limited lifespan, inability to proliferate, and resistance to genetic manipulation. Neutrophils can sense various cues, making them susceptible to activation by blood collection techniques, storage ...
Vanessa Krémer, Vanessa Krémer, Ophélie Godon, Pierre Bruhns, Friederike Jönsson, Friederike Jönsson, Luc de Chaisemartin, Luc de Chaisemartin, Luc de Chaisemartin   +8 more
doaj   +1 more source

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Science, 2020
A strong cocktail against SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the trimeric spike protein that decorates the virus and binds the ACE2 receptor.
M. A. Tortorici, M. Beltramello, Florian A. Lempp, D. Pinto, H. Dang, Laura E. Rosen, M. McCallum, John E. Bowen, A. Minola, S. Jaconi, F. Zatta, A. De Marco, B. Guarino, S. Bianchi, Elvin J Lauron, H. Tucker, Jiayi Zhou, A. Peter, C. Havenar-Daughton, Jason A. Wojcechowskyj, J. Case, Rita E. Chen, Hannah Kaiser, Martin Montiel-Ruiz, M. Meury, N. Czudnochowski, R. Spreafico, J. Dillen, C. Ng, Nicole Sprugasci, K. Culap, F. Benigni, R. Abdelnabi, S. Foo, M. A. Schmid, E. Cameroni, A. Riva, A. Gabrieli, M. Galli, M. Pizzuto, J. Neyts, Michael S. Diamond, Herbert W. Virgin, G. Snell, D. Corti, K. Fink, D. Veesler   +46 more
semanticscholar   +1 more source

State of play and clinical prospects of antibody gene transfer

Journal of Translational Medicine, 2017
Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
doaj   +1 more source

Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

Pharmaceutics, 2023
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases.
Laura Rué, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde   +6 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients

medRxiv, 2020
Background. COVID-19 is a pandemic with no specific antiviral treatments or vaccines. The urgent needs for exploring the neutralizing antibodies from patients with different clinical characteristics are emerging. Methods.
Xiaoli Wang, Xianghua Guo, Qianqian Xin, Yang Pan, Yalin Hu, Jing Li, Y. Chu, Yingmei Feng, Quanyi Wang   +8 more
semanticscholar   +1 more source

Functions of Antibodies

Microbiology Spectrum, 2014
ABSTRACTAntibodies can impact pathogens in the presence or in the absence of effector cells or effector molecules such as complement, and experiments can often sort out with precision the mechanisms by which an antibody inhibits a pathogenin vitro.
openaire   +5 more sources