Results 51 to 60 of about 3,802,616 (346)

State of play and clinical prospects of antibody gene transfer

Journal of Translational Medicine, 2017
Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
doaj   +1 more source

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Nature Communications, 2021
Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor.
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber   +21 more
doaj   +1 more source

A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Biomedicines, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler   +6 more
doaj   +1 more source

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Science, 2020
A strong cocktail against SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the trimeric spike protein that decorates the virus and binds the ACE2 receptor.
M. A. Tortorici, M. Beltramello, Florian A. Lempp, D. Pinto, H. Dang, Laura E. Rosen, M. McCallum, John E. Bowen, A. Minola, S. Jaconi, F. Zatta, A. De Marco, B. Guarino, S. Bianchi, Elvin J Lauron, H. Tucker, Jiayi Zhou, A. Peter, C. Havenar-Daughton, Jason A. Wojcechowskyj, J. Case, Rita E. Chen, Hannah Kaiser, Martin Montiel-Ruiz, M. Meury, N. Czudnochowski, R. Spreafico, J. Dillen, C. Ng, Nicole Sprugasci, K. Culap, F. Benigni, R. Abdelnabi, S. Foo, M. A. Schmid, E. Cameroni, A. Riva, A. Gabrieli, M. Galli, M. Pizzuto, J. Neyts, Michael S. Diamond, Herbert W. Virgin, G. Snell, D. Corti, K. Fink, D. Veesler   +46 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

Pharmaceutics, 2023
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases.
Laura Rué, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde   +6 more
doaj   +1 more source

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

Science, 2020
A beneficial cocktail Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics.
A. Baum, D. Ajithdoss, R. Copin, A. Zhou, Kathryn Lanza, N. Negron, M. Ni, Yi Wei, Kusha A. Mohammadi, B. Musser, G. Atwal, A. Oyejide, Yenny Goez-Gazi, John W Dutton, E. Clemmons, Hilary M Staples, Carmen Bartley, Benjamin Klaffke, K. Alfson, M. Gazi, O. Gonzalez, E. Dick, R. Carrion, Laurent Pessaint, Maciel Porto, Anthony Cook, Renita Brown, Vaneesha Ali, J. Greenhouse, Tammy Taylor, H. Andersen, M. Lewis, N. Stahl, A. Murphy, G. Yancopoulos, C. Kyratsous   +35 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Functions of Antibodies

Microbiology Spectrum, 2014
ABSTRACTAntibodies can impact pathogens in the presence or in the absence of effector cells or effector molecules such as complement, and experiments can often sort out with precision the mechanisms by which an antibody inhibits a pathogenin vitro.
openaire   +5 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source