Results 1 to 10 of about 3,380,520 (239)

Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement [PDF]

, 2014
Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients
AA Bousfiha, B Gathmann, B Gathmann, B Piqueras, B Seymour, C Casulo, C Wehr, DF Florescu, E Becerra, E Castigli, ES Resnick, FA Bonilla, G Gunther, H Chapel, H Chapel, H Griffiths, Hilary J. Longhurst, HM Chapel, I De La Torre, I Quinti, J Blore, J Shortt, JA Freeman, JD Edgar, John Dempster, JS Orange, JS Orange, K Warnatz, K Warnatz, L Mouthon, Lorena Lorenzo, M Lucas, M Makatsori, M Yomota, Matthaios Speletas, Matthew Buckland, ME Conley, ME Rose, MJ Boumans, N Ozaras, N Venhoff, NH Yip, P Bright, P McLaughlin, P Wood, R Herriot, S Baris, S Bernatsky, S Molica, Sai S. Duraisingham, Sofia Grigoriadou, SS Duraisingham, T Kawano, U Salzer, W Al-Herz, W Strober   +55 more
core   +11 more sources

Screening of potential vaccine candidates against pathogenic Brucella spp. using compositive reverse vaccinology

Veterinary Research, 2021
Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis in humans and various animals. The threat of brucellosis has increased, yet currently available live attenuated vaccines still have drawbacks.
Xiaodong Zai, Ying Yin, Fengyu Guo, Qiaoling Yang, Ruihua Li, Yaohui Li, Jun Zhang, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

Dual-target Bridging ELISA for Bispecific Antibodies

Bio-Protocol, 2022
Bispecific antibodies (BsAbs) are typically monoclonal antibody (mAb)–derived molecular entities engineered to bind to two distinct targets, including two antigens or two epitopes on the same antigen.
Min Pei, Yao Wang, Lei Tang, Weitao Wu, Chunhe Wang, Yi- Chen   +5 more
doaj   +1 more source

A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa

Frontiers in Public Health, 2023
Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems.
Busen Wang, Jianhua Li, Shipo Wu, Yudong Wang, Yi Chen, Yanfang Zhai, Xiaohong Song, Zhenghao Zhao, Zhe Zhang, Jinlong Zhang, Rui Yu, Lihua Hou, Wei Chen   +12 more
doaj   +1 more source

Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity

Scientific Reports, 2021
High tumor regulatory T (Treg) cell infiltration is associated with poor prognosis of many cancers. CD25 is highly expressed on tumor Treg cells and is a potential target for Treg deletion.
Deyong Song, Xiu Liu, Chuangchuang Dong, Qiaoping Wang, Chunjie Sha, Chuan Liu, Zhenfei Ning, Jing Han, Hong Liu, Mengqi Zong, Yanyan Zhao, Ying Li, Guangsheng Liu, Xin Shao, Changlin Dou   +14 more
doaj   +1 more source

A Bivalent COVID-19 Vaccine Based on Alpha and Beta Variants Elicits Potent and Broad Immune Responses in Mice against SARS-CoV-2 Variants

Vaccines, 2022
With the emergence and rapid spread of new pandemic variants, especially variants of concern (VOCs), the development of next-generation vaccines with broad-spectrum neutralizing activities is of great importance.
Rui Wang, Chunyun Sun, Juan Ma, Chulin Yu, Desheng Kong, Meng Chen, Xuejie Liu, Dandan Zhao, Shuman Gao, Shuyuan Kou, Lili Sun, Zeyong Ge, Jun Zhao, Kuokuo Li, Tao Zhang, Yanjing Zhang, Chunxia Luo, Xuefeng Li, Yang Wang, Liangzhi Xie   +19 more
doaj   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

An adenovirus-vectored RVF vaccine confers complete protection against lethal RVFV challenge in A129 mice

Frontiers in Microbiology, 2023
Instruction: Rift valley fever virus (RVFV) is a mosquito-transmitted bunyavirus that causes severe disease in animals and humans. Nevertheless, there are no vaccines applied to prevent RVFV infection for human at present.
Meng Hao, Ting Bian, Guangcheng Fu, Yi Chen, Ting Fang, Chuanyi Zhao, Shuling Liu, Changming Yu, Jianmin Li, Jianmin Li, Wei Chen   +10 more
doaj   +1 more source

A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques

npj Vaccines, 2023
Rift Valley fever virus (RVFV) is listed as a priority pathogen by the World Health Organization (WHO) because it causes serious and fatal disease in humans, and there are currently no effective countermeasures.
Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen   +13 more
doaj   +1 more source

A novel Galleria mellonella experimental model for zoonotic pathogen Brucella

Virulence, 2023
Brucellosis is a major threat to public health and animal husbandry. Several in vivo vertebrate models, such as mice, guinea pigs, and nonhuman primates, have been used to study Brucella pathogenesis, bacteria-host interactions, and vaccine efficacy ...
Shuyi Wang, Ying Yin, Xiaodong Zai, Yanfei Gu, Fengyu Guo, Fangze Shao, Yue Zhang, Yaohui Li, Ruihua Li, Jun Zhang, Junjie Xu, Wei Chen   +11 more
doaj   +1 more source