Results 211 to 220 of about 177,431 (250)
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The Effects of Cyclophosphamide on Antibody Dependent Cell-Mediated Cytotoxicity in Mice
Journal of Immunopharmacology, 1982The effect of cyclophosphamide (CY) on antibody dependent cell-mediated cytotoxicity (ADCC) was evaluated. The results indicated that a single injection of CY markedly increased ADCC activity of murine splenic cells. This effect was dose dependent and was maximal on day 7 after the drug injection.
M, Giordano, M A, Isturiz, L, Colombo
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Antibody‐Dependent Cell‐Mediated Cytotoxicity in Various Orders of Vertebrates
Scandinavian Journal of Immunology, 1977By using chicken antibodies and chicken lymphoid cells, we could demonstrate antibody‐dependent cytotoxicity (ADCC) against haptenated chicken erythrocytes. ADCC could be demonstrated either by treating the target cells with antibody (sensitization) or by treating the effector cells (arming).
T, Imir, E, Saksela, O, Mäkelä
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Antibody-dependent cell-mediated cytotoxicity (ADCC) in Parkinson's disease
Journal of the Neurological Sciences, 1993The possible role of a non-specific cell-mediated immune reaction in the pathogenesis of Parkinson's disease (PD) is discussed. It was found that the killer cell activity of PD patients below 60 years of age was significantly lower than in the older age groups or in the age-matched control group.
M, Bokor +4 more
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The role of protein synthesis in antibody-dependent cell-mediated cytotoxicity
Cellular Immunology, 1977Abstract Antibody-depedent cell-mediated cytotoxicity (ADCC) could be initiated without protein synthesis [human peripheral blood lymphocytes as effector cells incubated with 10−3M cycloheximide, (Cy)], although the reaction did not achieve its full lytic ability. This partial inhibition of ADCC was dependent on the dose of Cy.
M, Isturiz, R L, Cardoni
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Antibody-dependent cell-mediated cytotoxicity of cryopreserved human monocytes
Cryobiology, 1984Human peripheral blood monocytes (PBM) modulate and participate in a variety of host defences. Cryopreservation of PBM has facilitated studies of their function. Peripheral blood samples cleared of red cells and granulocytes by centrifugation over Ficoll-Hypaque were cryopreserved at 1 degree C/min in 10% Me2SO and stored at -150 degrees C ...
V O, Shah, D L, McCarley, R S, Weiner
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Methods for Measuring Antibody-Dependent Cell-Mediated Cytotoxicity In Vitro
2014Antibody-dependent cell-mediated cytotoxicity (ADCC) is a relevant characteristic to measure for a number of therapeutic monoclonal antibodies (mAbs) under development. ADCC is a mechanism by which antibody-opsonized, infected, or cancerous cells are destroyed by FcγRIII (CD16)-expressing effector cells.
Aaron S, Miller +2 more
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Effects of carrageenan on spontaneous and antibody-dependent cell-mediated cytotoxicity
Cellular Immunology, 1978Abstract We examined the effect of carrageenan on in vitro antibody-dependent cell-mediated cytolysis (ADCC) and spontaneous cell-mediated cytolysis (SCMC) in cultures of human peripheral blood mononuclear cells (PBL). Carrageenan, when present in the assay, nonspecifically reduced ADCC and SCMC against both Chang and chicken erythrocyte (CRBC ...
W J, Catalona, T L, Ratliff, R E, McCool
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Evaluating Antibody-Dependent Cell-Mediated Cytotoxicity by Flow Cytometry
2019Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism in which immune cell activation is induced by the cross-linking of CD16 with the Fc region of antibodies that at the same time bind specifically to cell surface antigens. ADCC stimulates the secretion of perforin, granzymes, and cytokines leading to lysis of the malignant cells ...
Irene, van der Haar Àvila +4 more
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Antibody‐Dependent Cell‐Mediated Cytotoxicity in the Mouse
Scandinavian Journal of Immunology, 1974The surface characteristics of the mouse spleen cells mediating antibody‐dependent cytotoxicity (ADCC) against antigen‐coated chicken erythrocytes have been studied by several different column fractionation methods The major effector cells in this system were shown to be surface‐adherent and could be depleted from spleen cells by passage through glass ...
H F, Pross +3 more
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Antibody-dependent cell-mediated cytotoxicity
AIDS, 1988This study confirms the presence of detectable antibody-dependent cell-mediated cytotoxicity (ADCC) towards both HTLV-I- and HIV-1-infected cell lines, mediated by normal donor peripheral blood mononuclear cells and either by antibody from adult T-cell lymphoma and tropical spastic paraparesis patients (HTLV-I) or by antibody from sera of patients with
A L, Sinclair +6 more
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