Results 91 to 100 of about 20,805 (196)

HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses. [PDF]

Sci Immunol, 2020
Burn Aschner C, Loh LN, Galen B, Delwel I, Jangra RK, Garforth SJ, Chandran K, Almo S, Jacobs WR, Ware CF, Herold BC.   +10 more
europepmc   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

MedComm, Volume 7, Issue 10, October 2026.
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan, Huiru Zhang, Deyang Kong, Yu Sun, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Haizeng Zhang, Lin Feng   +10 more
wiley   +1 more source

Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population

Frontiers in Immunology
BackgroundBeyond the role of neutralizing antibodies in protecting against SARS-CoV-2, Fc-mediated antibodies functions may offer additional immune defense.
Mingzhi Gan, Mingzhi Gan, Weiwei Han, Chuang Li, Simin Li, Zhuangzhuang Huang, Lingjie Xu, Xiaoyu Xu, Xiangjun Zhai, Xiangjun Zhai, Yuxin Chen, Jingxin Li, Jingxin Li   +12 more
doaj   +1 more source

Selective Depletion of Tumor‐Infiltrating CD4+CCR8+ Tregs by AZ084, a Novel CCR8 Antagonist

Cancer Science, Volume 117, Issue 10, Page 2719-2732, October 2026.
AZ084, a novel CCR8 antagonist, selectively targets tumor‐infiltrating CD4+CCR8+ Tregs, reduces their immunosuppressive function, and decreases IL‐10/TGF‐β production. ABSTRACT Regulatory T cells (Tregs) are key mediators of immunosuppression in ovarian cancer, yet strategies for selectively targeting tumor‐infiltrating Tregs remain limited.
Yepeng Mao, Ziqi Tao, Shuna Liu, Zhijie Liu, Yuelu Zhang, Lingfei Zhou, Lina Yan, Ting Wang, Wenwen Shang, Jianfang Lou, Xi Huang, Xin Fu, Fang Wang   +12 more
wiley   +1 more source

Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro

Frontiers in Immunology
IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and rapid in vivo ...
Hesham M. Shehata, Pranay Dogra, Sarah Gierke, Patrick Holder, Shomyseh Sanjabi   +4 more
doaj   +1 more source

EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma

Journal of Translational Medicine
Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been shown to improve survival in nasopharyngeal carcinoma (NPC) patients. However, a correlation between the expression of EGFR and the response to cetuximab has not been observed,
Qian Zhu, Xiao-Bing Duan, Hao Hu, Rui You, Tian-Liang Xia, Tao Yu, Tong Xiang, Ming-Yuan Chen   +7 more
doaj   +1 more source

CD80 (B7-1) as a potential therapeutic target in Epstein–Barr virus‑associated B cell diseases

Scientific Reports
Epstein-Barr virus (EBV)-associated B-cell lymphomas pose a therapeutic challenge due to their resistance to conventional chemotherapy and limited efficacy of current targeted approaches.
Rin Yoshizato, Mariko Miura, Yumi Tamura, Yohei Kawano, Yuya Hokama, Nanami Soda, Yusei Ota, Kotomi Yamashita, Taisei Fukushima, Masataka Ishimura, Shouichi Ohga, Tomoharu Yasuda   +11 more
doaj   +1 more source

Correction to: Immunotherapy Utilizing the Combination of Natural Killer- and Antibody Dependent Cellular Cytotoxicity (ADCC)-Mediating Agents with Poly (ADP-ribose) polymerase (PARP) Inhibition. [PDF]

J Immunother Cancer, 2019
Fenerty KE, Padget M, Wolfson B, Gameiro SR, Su Z, Lee JH, Rabizadeh S, Soon-Shiong P, Hodge JW.   +8 more
europepmc   +1 more source