Results 71 to 80 of about 20,805 (196)

Fc-Mediated Effector Functions of Anti-NS1 Antibodies in Dengue

Viruses
The non-structural protein 1 (NS1) of dengue virus (DENV) plays a multifaceted role in viral pathogenesis and immune modulation. Although vaccine strategies have traditionally focused on neutralizing antibodies against the envelope (E) protein, recent ...
Romchat Kraivong
doaj   +1 more source

ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection

PLoS Pathogens, 2021
Despite antibody-dependent cellular cytotoxicity (ADCC) responses being implicated in protection from HIV-1 infection, there is limited evidence that they control virus replication.
Dieter Mielke, Gama Bandawe, Jie Zheng, Jennifer Jones, Melissa-Rose Abrahams, Valerie Bekker, Christina Ochsenbauer, Nigel Garrett, Salim Abdool Karim, Penny L. Moore, Lynn Morris, David Montefiori, Colin Anthony, Guido Ferrari, Carolyn Williamson   +14 more
doaj  

Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma. [PDF]

PLoS One, 2021
Tso FY, Lidenge SJ, Poppe LK, Peña PB, Privatt SR, Bennett SJ, Ngowi JR, Mwaiselage J, Belshan M, Siedlik JA, Raine MA, Ochoa JB, Garcia-Diaz J, Nossaman B, Buckner L, Roberts WM, Dean MJ, Ochoa AC, West JT, Wood C.   +19 more
europepmc   +1 more source

Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC). [PDF]

Sci Rep, 2021
Khanna V, Kim H, Zhang W, Larson P, Shah M, Griffith TS, Ferguson D, Panyam J.   +7 more
europepmc   +1 more source

Neutralization and ADCC reveal divergent spike-subdomain targeting across SARS-CoV-2 vaccine platforms in an African cohort

iScience
Summary: Evaluating demographically diverse antibody response dynamics remains relevant to developing better vaccines against SARS-CoV-2 and related coronaviruses.
Gerald Kevin Oluka, Joseph Ssebwana Katende, Laban Kato, Violet Ankunda, Jackson Sembera, Peter Ejou, Geoffrey Odoch, Angella Namuyanja, Pontiano Kaleebu, Jennifer Serwanga   +9 more
doaj   +1 more source

Deficient IL-2 Produced by Activated CD56+ T Cells Contributes to Impaired NK Cell-Mediated ADCC Function in Chronic HIV-1 Infection

Frontiers in Immunology, 2019
Background: Antibody-dependent cellular cytotoxicity (ADCC), which mainly mediated by natural killer (NK) cells, may play a critical role in human immunodeficiency virus type-1 (HIV-1) disease progression. However, the potential mechanisms that affecting
Zhe Xie, Jiajia Zheng, Yuya Wang, Dan Li, Tuohutaerbieke Maermaer, Yuantao Li, Jing Tu, Qiang Xu, Hua Liang, Weiping Cai, Tao Shen   +10 more
doaj   +1 more source

ADCC: the rock band led by therapeutic antibodies, tumor and immune cells

Frontiers in Immunology
Antibody-dependent cellular cytotoxicity (ADCC) is a critical mechanism by which therapeutic antibodies leverage the immune system to target and eliminate cancer cells. The key agents of ADCC are natural killer (NK) cells, specifically targeting antibody-
Roos Vincken, Roos Vincken, Uxue Armendáriz-Martínez, Ana Ruiz-Sáenz, Ana Ruiz-Sáenz   +4 more
doaj   +1 more source

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

mBio, 2018
The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses.
Jonathan Richard, Jérémie Prévost, Amy E. Baxter, Benjamin von Bredow, Shilei Ding, Halima Medjahed, Gloria G. Delgado, Nathalie Brassard, Christina M. Stürzel, Frank Kirchhoff, Beatrice H. Hahn, Matthew S. Parsons, Daniel E. Kaufmann, David T. Evans, Andrés Finzi   +14 more
doaj   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Autoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection

American Journal of Hematology, Volume 101, Issue 10, Page 2592-2604, October 2026.
ABSTRACT Plasmodium vivax‐associated anemia is a multifactorial clinical outcome, in which the destruction of uninfected red blood cells (uRBCs) plays a major role in disease development and severity. Here, we identified autoantibody targets within the extracellular loops of Band 3 (B3), a major erythrocyte transmembrane protein.
Aline Marzano‐Miranda, Vanessa G. Fraga, Cor Jésus F. Fontes, Simone Ladeia‐Andrade, Marcelo U. Ferreira, Daniella C. Bartholomeu, Érika M. Braga   +6 more
wiley   +1 more source