Results 201 to 210 of about 78,855 (233)
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Protocol for the murine antibody-dependent cellular phagocytosis assay
Methods in Cell Biology, 2023Antibody-dependent cellular phagocytosis (ADCP) is a process through which myeloid cells are able to exert their phagocytic function after recognition of opsonized bacteria, viruses, infected cells or any cells targeted by a specific antibody. ADCP of tumor cells represents a potent effector mechanism of monoclonal antibody therapy mediated by tumor ...
Fulvia Vascotto +2 more
exaly +3 more sources
A novel method for determining antibody-dependent cellular phagocytosis
Journal of Immunological Methods, 2019Antibody-based therapeutics are powerful tools to treat disease. While their mechanism of action (MOA) always involves binding to a specific target via the Fab region of the antibody, the induction of effector functions through the Fc region of the antibody is equally important for antibody therapeutics designed to deplete tumor cells.
An Song, Shan Chung, Chris Langsdorf
exaly +3 more sources
Method for Measurement of Antibody-Dependent Cellular Phagocytosis
2021Antibody-based therapeutics are powerful tools to treat disease. While their mechanism of action (MOA) always involves binding to a specific target via the antibody-binding fragment (Fab) region of the antibody, the induction of immune-mediated effector functions through the fragment crystallizable (Fc) region is a vital aspect of antibody therapeutics
Lynn, Kamen +3 more
openaire +2 more sources
Biomaterials, 2021
Tumor-associated macrophages (TAMs) exist in nearly all tumors, and form a major part of the tumor microenvironment. TAMs are divided into two groups: tumor-suppressing M1 type and tumor-promoting M2 type. Most TAMs are educated by the tumor cells to become M2 type, which support tumor growth and make immunotherapy ineffective.
Shun' Ichi Kuroda, Masaharu Somiya
exaly +3 more sources
Tumor-associated macrophages (TAMs) exist in nearly all tumors, and form a major part of the tumor microenvironment. TAMs are divided into two groups: tumor-suppressing M1 type and tumor-promoting M2 type. Most TAMs are educated by the tumor cells to become M2 type, which support tumor growth and make immunotherapy ineffective.
Shun' Ichi Kuroda, Masaharu Somiya
exaly +3 more sources
Complement-dependent phagocytosis as a regulator of antibody-dependent cellular cytotoxicity
The Journal of Immunology, 2022Abstract While monoclonal antibodies (mAb), such as αCD20, have significantly improved patient outcomes for B cell malignancies, patient responses vary and drug resistance can occur. One proposed limitation is the reduction of innate immune effector functions such as antibody dependent cellular phagocytosis (ADCP) – the principal ...
Carly M Van Wagoner +6 more
openaire +1 more source
Breast Cancer Research and Treatment, 1999
MDX-210 is a bispecific antibody (BsAb) with specificity for both the proto-oncogene product of HER-2/neu (c-erbB-2) and FcgammaRI (CD64). HER-2/neu is overexpressed in malignant tissue of approximately 30% of patients with breast cancer, and FcgammaRI is expressed on human monocytes, macrophages, and IFN-gamma activated granulocytes.
Charuwan Akewanlop +2 more
exaly +3 more sources
MDX-210 is a bispecific antibody (BsAb) with specificity for both the proto-oncogene product of HER-2/neu (c-erbB-2) and FcgammaRI (CD64). HER-2/neu is overexpressed in malignant tissue of approximately 30% of patients with breast cancer, and FcgammaRI is expressed on human monocytes, macrophages, and IFN-gamma activated granulocytes.
Charuwan Akewanlop +2 more
exaly +3 more sources
A method for determining antibody-dependent cellular phagocytosis
The Journal of Immunology, 2017Abstract Antibody-based therapeutics are a powerful tool to treat diseases. While their mechanism of action (MOA) always involves binding to a specific target via the Fab region of the antibody, the induction of effector functions through the Fc region of the antibody is equally important for antibody therapeutics designed to deplete ...
Lynn A Kamen +4 more
openaire +1 more source
A real-time antibody-dependent cellular phagocytosis assay by live cell imaging
Journal of Immunological MethodsAntibody-dependent cellular phagocytosis (ADCP) is a cellular process by which antibody-opsonized targets (pathogens or cells) activate the Fc receptors on the surface of phagocytes to induce phagocytosis, resulting in internalization and degradation of pathogens or target cells through phagosome acidification.
Yonglian Sun +2 more
exaly +3 more sources
Journal of Bioscience and Bioengineering, 2011
We previously reported that chimeric monoclonal antibodies (mAbs) with tandemly repeated Fc domains, which were developed by introducing tandem repeats of Fc domains downstream of 2 Fab domains, augmented binding avidities for all Fcγ receptors, resulting in enhanced antibody (Ab)-dependent cellular cytotoxicity.
Yasuhiko Masuho
exaly +3 more sources
We previously reported that chimeric monoclonal antibodies (mAbs) with tandemly repeated Fc domains, which were developed by introducing tandem repeats of Fc domains downstream of 2 Fab domains, augmented binding avidities for all Fcγ receptors, resulting in enhanced antibody (Ab)-dependent cellular cytotoxicity.
Yasuhiko Masuho
exaly +3 more sources