Results 211 to 220 of about 78,855 (233)
Some of the next articles are maybe not open access.
Journal of Biotechnology, 2020
Therapeutic monoclonal antibodies (mAbs), particularly of the IgG1 subclass, are capable of effector function activities that may be important for their mechanism of action. One such effector function activity is Antibody Dependent Cellular Phagocytosis (ADCP), which has been shown to be mediated primarily through the activating FcγR, FcγRIIa, on ...
Scott Kuhns, Qingchun Zhang
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Therapeutic monoclonal antibodies (mAbs), particularly of the IgG1 subclass, are capable of effector function activities that may be important for their mechanism of action. One such effector function activity is Antibody Dependent Cellular Phagocytosis (ADCP), which has been shown to be mediated primarily through the activating FcγR, FcγRIIa, on ...
Scott Kuhns, Qingchun Zhang
exaly +3 more sources
Journal of Immunological Methods, 2021
Lack of a simple, high throughput antibody-dependent cellular phagocytosis (ADCP) assay has limited our understanding of its potential role of in hepatitis C (HCV) infection. Here, we optimised a flow-cytometry based ADCP assay using HCV envelope (E2)-protein coated microbeads that were opsonised with anti-E2 monoclonal IgG antibody (αE2 mAb) and the ...
Anurag, Adhikari +6 more
openaire +2 more sources
Lack of a simple, high throughput antibody-dependent cellular phagocytosis (ADCP) assay has limited our understanding of its potential role of in hepatitis C (HCV) infection. Here, we optimised a flow-cytometry based ADCP assay using HCV envelope (E2)-protein coated microbeads that were opsonised with anti-E2 monoclonal IgG antibody (αE2 mAb) and the ...
Anurag, Adhikari +6 more
openaire +2 more sources
Leukemia, 2022
Redirection of tumor-associated macrophages to eliminate tumor cells holds great promise for overcoming therapeutic resistance to rituximab and other antibody drugs. Here, we determined the expression of ectonucleotidases CD39 and CD73 in diffuse large B-cell lymphoma (DLBCL), and examined the impact of extracellular ATP (eATP) metabolism on macrophage-
Mika Casey +12 more
openaire +4 more sources
Redirection of tumor-associated macrophages to eliminate tumor cells holds great promise for overcoming therapeutic resistance to rituximab and other antibody drugs. Here, we determined the expression of ectonucleotidases CD39 and CD73 in diffuse large B-cell lymphoma (DLBCL), and examined the impact of extracellular ATP (eATP) metabolism on macrophage-
Mika Casey +12 more
openaire +4 more sources
Decreased phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) in type-1 diabetes.
Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1981Leucocyte-mediated phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) were tested in 48 children with type-1 diabetes and in 22 healthy children. Both phagocytosis and ADCC for opsonized 51Cr-erythrocytes significantly decreased in the diabetics.
Sabioncello, Ante +4 more
openaire +2 more sources
Clinical Cancer Research
Abstract Monoclonal antibodies (mAb) used in the clinic can engage the immune system through their Fc domains, eliciting effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maria Armero +5 more
openaire +2 more sources
Abstract Monoclonal antibodies (mAb) used in the clinic can engage the immune system through their Fc domains, eliciting effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maria Armero +5 more
openaire +2 more sources
An image-based real time method to measure antibody-dependent cellular phagocytosis
The Journal of ImmunologyAbstract Antibody-dependent cellular phagocytosis (ADCP) is an important mechanism of action of therapeutic antibodies. In vitro quantification of ADCP has been technically challenging. Fluorescence microscopy and flow cytometry based assays were traditionally used to measure ADCP activity, these methods were static measurements at ...
Yongchang Shi +5 more
openaire +1 more source
Abstract 2059: An image-based real time method to measure antibody-dependent cellular phagocytosis
Cancer ResearchAbstract Antibody-dependent cellular phagocytosis (ADCP) is an important mechanism of action of therapeutic antibodies. In vitro quantification of macrophage phagocytosis has been technically challenging. Flow cytometry assays were traditionally used for ADCP activity measurements, these methods were static measurements at certain time ...
Jianyong Wang +5 more
openaire +1 more source
Method for Measurement of Antibody-Dependent Cellular Phagocytosis
Methods in Molecular Biology, 2022Shan Chung, Benjamin Ordonia
exaly