Results 31 to 40 of about 1,768,583 (320)

Seasonal variation of immune response to heterologous erythrocytes in natural populations of red‐backed (Clethrionomys rutilus) and gray‐sided (C. rufocanus) voles in Western Siberia

Ecology and Evolution, 2022
We studied the seasonal variation of adaptive humoral immunity (AHI) in northern red‐backed vole (Clethrionomys rutilus Pallas, 1779, RBV) and gray‐sided vole (C. rufocanus Sundevall, 1846, GSV) in Tomsk region of Western Siberia.
Larisa B. Kravchenko, Konstantin A. Rogovin   +1 more
doaj   +1 more source

Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.

PLoS ONE, 2017
Vaccines that can rapidly induce strong and robust antibody-mediated immunity could improve protection from certain infectious diseases for which current vaccine formulations are inefficient.
Genevieve M Weir, Mohan Karkada, David Hoskin, Marianne M Stanford, Lisa MacDonald, Marc Mansour, Robert S Liwski   +6 more
doaj   +1 more source

Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE. [PDF]

PLoS ONE, 2014
Natalizumab is a humanized monoclonal antibody against the leukocyte adhesion molecule very late antigen (VLA)-4, and is currently an approved therapy for patients with relapsing-remitting multiple sclerosis (RRMS).
John E Mindur, Naoko Ito, Suhayl Dhib-Jalbut, Kouichi Ito   +3 more
doaj   +1 more source

Detection of Tumor Cell Surface-reactive Antibodies

Bio-Protocol, 2014
Vaccine-based immunotherapy is being used to treat dogs with primary brain tumors. The vaccines are composed of a lysate of autologous tumor cells, which stimulate an immune response producing tumor specific antibodies that are capable of inducing ...
Brian Andersen, Michelle Goulart, Michael Olin, G. Pluhar   +3 more
doaj   +1 more source

Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus

Journal of Experimental Medicine, 1990
We quantitated and characterized the changes in the human B cell repertoire, at the clonal level, before and after immunization with rabies virus. Moreover, we generated 10 monoclonal cell lines producing IgM, IgG, and IgA antibodies to the virus.
Y. Ueki, I. Goldfarb, N. Harindranath, M. Gore, H. Koprowski, A. Notkins, P. Casali   +6 more
semanticscholar   +1 more source

Contribution of long-lived plasma cells to antibody-mediated allograft rejection

Clinical Transplantation and Research
Persistent alloantigens derived from allograft tissues can be recognized by the host’s alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies that are key drivers of ...
Eunkyeong Jang, Jeehee Youn
doaj   +1 more source

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

Cell Reports
Summary: SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees.
Masanori Isogawa, Masahiro Shinoda, Ryutaro Kotaki, Kazutaka Terahara, Taishi Onodera, Kiyomi Kabasawa, Mio Toyama-Kousaka, Mizuki Fujisawa, Mitsukaze Watanabe, Keisuke Tonouchi, Tommy Terooatea, Ayumi Kitano, Yu Adachi, Saya Moriyama, Tomohiro Takano, Shuetsu Fukushi, Takayuki Matsumura, Kazuo Yamashita, Masaharu Shinkai, Yoshimasa Takahashi   +19 more
doaj   +1 more source

Human CD81 directly enhances T_h1 and T_h2 cell activation, but preferentially induces proliferation of T_h2 cells upon long-term stimulation

BMC Immunology, 2003
Background CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to costimulate T cell activation in murine T cells, and is involved in development of Th2 immune responses in mice.
Maecker Holden T
doaj   +1 more source

Serial Transfer of Antibody Producing Cells on the Chorioallantoic Membrane.

Experimental Biology and Medicine, 1963
SummarySerial transfer of foci on the CAM through at least 3 transfers is confirmed. Significant titers of antibody were found in a high percentage of recipient eggs 5 days after inoculation of spleen cells from an immunized chicken. The transfer of cells from the CAM of these eggs to other eggs resulted in development of foci, but the proportion of ...
J. S. Ingraham, David W. Talmage, E. P. Cohen   +2 more
openaire   +3 more sources

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread. [PDF]

PLoS Pathogens, 2016
Skin infection with the poxvirus vaccinia (VV) elicits a powerful, inflammatory cellular response that clears virus infection in a coordinated, spatially organized manner.
Stephanie S Cush, Glennys V Reynoso, Olena Kamenyeva, Jack R Bennink, Jonathan W Yewdell, Heather D Hickman   +5 more
doaj   +1 more source