Results 91 to 100 of about 526,913 (304)

Diversification of specificity after maturation of the antibody response to the HIV gp41 epitope ELDKWA.

PLoS ONE, 2012
During maturing antibody responses the increase in affinity for target antigens is achieved by genetic diversification of antibody genes followed by selection for improved binding.
Henry N White, Qing-Hai Meng
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The structure of human CD23 and its interactions with IgE and CD21

, 2005
The low-affinity immunoglobulin E ( IgE) receptor, CD23 ( Fc epsilon RII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.
Grundy, GJ, Hibbert, R G, Peter Teriete, Jonathan P. Hannan, Brian J. Sutton, Rajko Reljić, Gould, H J, Rebecca L. Beavil, Holers, V M, Hannah J. Gould, Holers, VM, Richard G. Hibbert, McDonnell, JM, Gabrielle J. Grundy, Hibbert, RG, Sutton, BJ, James M. McDonnell, Reljic, R, V. Michael Holers, Grundy, G J, Gould, HJ, Hannan, JP, Beavil, R L, Sutton, B J, Teriete, P, Beavil, RL, McDonnell, J M; id_orcid, Hannan, J P   +27 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.

PLoS Computational Biology, 2019
Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and ...
Daniel A Cannon, Lu Shan, Qun Du, Lena Shirinian, Keith W Rickert, Kim L Rosenthal, Martin Korade, Lilian E van Vlerken-Ysla, Andrew Buchanan, Tristan J Vaughan, Melissa M Damschroder, Bojana Popovic   +11 more
doaj   +1 more source

Physical epistatic landscape of antibody binding affinity

, 2017
Affinity maturation produces antibodies that bind antigens with high specificity by accumulating mutations in the antibody sequence. Mapping out the antibody-antigen affinity landscape can give us insight into the accessible paths during this rapid ...
Thierry Mora, Aleksandra M. Walczak, Rhys M. Adams, Justin B. Kinney   +3 more
core   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Integrated scale down of the primary downstream purification process and assessment of alternative process options for the production of an ovine polyclonal antibody based anti-venom.

, 2005
This thesis describes the development of a linked 1000th scale mimic of four distinct unit operations, including precipitation and centrifugation. These operations are utilised during the production of an anti-snake venom Fab fragment. A new approach has
Neal, G.E.
core  

Antibody variants with improved affinity [PDF]

, 2008
Therapeutische Antikörper gewinnen bei der Behandlung verschiedener Krebsarten mehr und mehr an Bedeutung. Ein Zielmolekül für eine antikörperbasierte Therapie ist Mucin 1 (MUC1).
Thie, Holger
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source