Results 161 to 170 of about 755,061 (295)

Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. [PDF]

Anal Bioanal Chem, 2021
Murray LP, Govindan R, Mora AC, Munro JB, Mace CR.   +4 more
europepmc   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Nucleotide context models outperform protein language models for predicting antibody affinity maturation. [PDF]

PLoS Comput Biol
Johnson MM, Sung K, Haddox HK, Vora AA, Araki T, Victora GD, Song YS, Fukuyama J, Matsen Iv FA.   +8 more
europepmc   +1 more source

Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications

Advanced Materials, EarlyView.
Electrolyte‐gated organic field‐effect transistors (EGOFETs) are integrated with lateral flow (LF) paper fluidics to create a reusable, portable, and low‐cost point‐of‐care (PoC) diagnostic test. The devices are validated for Human Immunoglobulin G detection, achieving high sensitivity (0.1 fm), selectivity, and reproducibility with rapid results in 20–
María Jesús Ortiz‐Aguayo, Carme Martínez‐Domingo, Diego Gutiérrez, Dean Kos, Marta Mas‐Torrent   +4 more
wiley   +1 more source

Regulated somatic hypermutation enhances antibody affinity maturation. [PDF]

Nature
Merkenschlager J, Pyo AGT, Silva Santos GS, Schaefer-Babajew D, Cipolla M, Hartweger H, Gitlin AD, Wingreen NS, Nussenzweig MC.   +8 more
europepmc   +1 more source

Pretrainable Geometric Graph Neural Network for Antibody Affinity Maturation

, 2023
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J.   +8 more
europepmc   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Variability in Severe Acute Respiratory Syndrome Coronavirus 2 IgG Antibody Affinity to Omicron and Delta Variants in Convalescent and Community mRNA-Vaccinated Individuals. [PDF]

Immunohorizons, 2022
Tu MK, Chiang SH, Wong DTW, Strom CM.
europepmc   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Significantly enhancing human antibody affinity via deep learning and computational biology-guided single-point mutations. [PDF]

Brief Bioinform
Li J, Zhang C, Xia W, Kan HW, Huang K, Li S, Ige MA, Yu Q, Zhao J, Wan X, Zhang JZH, Zhang H.   +11 more
europepmc   +1 more source