Results 171 to 180 of about 526,913 (304)

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

AbDist: a lightweight, distance-based model for antibody affinity prediction as an interpretable benchmark for machine learning models. [PDF]

MAbs
Hoffstedt M, Wowra J, Wätzig H, Baumann K.   +3 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Nucleotide context models outperform protein language models for predicting antibody affinity maturation. [PDF]

PLoS Comput Biol
Johnson MM, Sung K, Haddox HK, Vora AA, Araki T, Victora GD, Song YS, Fukuyama J, Matsen Iv FA.   +8 more
europepmc   +1 more source

Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. [PDF]

Anal Bioanal Chem, 2021
Murray LP, Govindan R, Mora AC, Munro JB, Mace CR.   +4 more
europepmc   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Improved VSV-Ebola-GP booster vaccination approach promotes antibody affinity maturation and durable anti-Ebola immunity in humans. [PDF]

Nat Immunol
Khurana S, Posadas O, Kardava L, Coyle EM, Ravichandran S, Grubbs G, McConnell R, Rouphael N, Poliquin G, Langley JM, Chu E, Follmann DA, Shang X, Li Y, Moir S, Davey RT.   +15 more
europepmc   +1 more source

The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy

, 2004
PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core  

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Regulated somatic hypermutation enhances antibody affinity maturation. [PDF]

Nature
Merkenschlager J, Pyo AGT, Silva Santos GS, Schaefer-Babajew D, Cipolla M, Hartweger H, Gitlin AD, Wingreen NS, Nussenzweig MC.   +8 more
europepmc   +1 more source