Results 191 to 200 of about 526,913 (304)

Local and Global Rigidification Upon Antibody Affinity Maturation. [PDF]

Front Mol Biosci, 2020
Fernández-Quintero ML, Loeffler JR, Bacher LM, Waibl F, Seidler CA, Liedl KR.   +5 more
europepmc   +1 more source

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis. [PDF]

MAbs, 2021
Chang HY, Wu S, Li Y, Zhang W, Burrell M, Webster CI, Shah DK.   +6 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Pretrainable geometric graph neural network for antibody affinity maturation. [PDF]

Nat Commun
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J.   +8 more
europepmc   +1 more source

Predicting antibody affinity changes upon mutations by combining multiple predictors. [PDF]

Sci Rep, 2020
Kurumida Y, Saito Y, Kameda T.
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation [PDF]

Nat Commun, 2020
Hurlburt NK, Wan Y, Stuart AB, Feng J, McGuire AT, Stamatatos L, Pancera M.   +6 more
europepmc   +2 more sources

Development and experimental validation of computational methods for human antibody affinity enhancement. [PDF]

Brief Bioinform
Li J, Liao L, Zhang C, Huang K, Zhang P, Zhang JZH, Wan X, Zhang H.   +7 more
europepmc   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

Author Correction: Pretrainable geometric graph neural network for antibody affinity maturation. [PDF]

Nat Commun
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J.   +8 more
europepmc   +1 more source