Results 171 to 180 of about 751,456 (299)

Significantly enhancing human antibody affinity via deep learning and computational biology-guided single-point mutations. [PDF]

Brief Bioinform
Li J, Zhang C, Xia W, Kan HW, Huang K, Li S, Ige MA, Yu Q, Zhao J, Wan X, Zhang JZH, Zhang H.   +11 more
europepmc   +1 more source

Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients. [PDF]

Nat Commun, 2021
Tang J, Ravichandran S, Lee Y, Grubbs G, Coyle EM, Klenow L, Genser H, Golding H, Khurana S.   +8 more
europepmc   +1 more source

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Predicting Antibody Affinity Changes upon Mutation Based on Unbound Protein Structures. [PDF]

Int J Mol Sci
Chen Z, He S, Chi X, Bo X.
europepmc   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

On the role of antibody affinity and avidity in the IgE-mediated allergic response. [PDF]

Allergy
Bachmann MF, Krenger PS, Mohsen MO, Kramer MF, Starchenka S, Whitehead P, Vogel M, Heath MD.   +7 more
europepmc   +1 more source

Local and Global Rigidification Upon Antibody Affinity Maturation. [PDF]

Front Mol Biosci, 2020
Fernández-Quintero ML, Loeffler JR, Bacher LM, Waibl F, Seidler CA, Liedl KR.   +5 more
europepmc   +1 more source

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis. [PDF]

MAbs, 2021
Chang HY, Wu S, Li Y, Zhang W, Burrell M, Webster CI, Shah DK.   +6 more
europepmc   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Pretrainable geometric graph neural network for antibody affinity maturation. [PDF]

Nat Commun
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J.   +8 more
europepmc   +1 more source