Results 51 to 60 of about 751,456 (299)

Maximizing activity and selectivity of antibody-mediated effector functions using antibody mixtures

mAbs
Fc-mediated effector functions are key for conferring potent antibody-mediated killing of cancer cells. However, it is difficult to achieve highly selective targeting of cancer cells while minimizing toxicity on healthy tissue because of the expression ...
Tiexin Wang, Alec A. Desai, Greg M. Thurber, Peter M. Tessier   +3 more
doaj   +1 more source

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine   +22 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Physiological Considerations for Modeling in vivo Antibody-Target Interactions

Frontiers in Pharmacology, 2022
The number of therapeutic antibodies in development pipelines is increasing rapidly. Despite superior success rates relative to small molecules, therapeutic antibodies still face many unique development challenges. There is often a translational gap from
Tyler Dunlap, Yanguang Cao, Yanguang Cao
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Deep learning guided high-throughput virtual screening for in vitro antibody maturation [PDF]

BIO Web of Conferences
Antibody affinity maturation is a crucial step in therapeutic antibody discovery. In this study, we present a virtual screening pipeline that integrates protein docking with deep learning-based structural prediction to identify antibody mutants with ...
Gong Chen, Liu Hongde
doaj   +1 more source

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. [PDF]

, 2019
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Dong, Jie-Xian, Hammock, Bruce, Jia, Bao-Zhu, Lei, Hong-Tao, Luo, Lin, Shen, Yu-Dong, Wang, Hong, Wei, Xiao-Qun, Xu, Zhen-Lin, Yang, Jin-Yi   +9 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

Frontiers in Immunology
Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed newborn infants and their mothers for nine months.
Allan Lugaajju, Richard Idro, Stephen Kiwuwa, James G. Beeson, James G. Beeson, James G. Beeson, Damien R. Drew, Susanne E. Mortazavi, Susanne E. Mortazavi, Sara Linse, Kristina E. M. Persson, Kristina E. M. Persson   +11 more
doaj   +1 more source

Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses, 2021
Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3
Ivan K. Baykov, Pavel Y. Desyukevich, Ekaterina E. Mikhaylova, Olga M. Kurchenko, Nina V. Tikunova   +4 more
doaj   +1 more source