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The generation of antibody diversity
American Journal of Hematology, 1982AbstractBy their nature, antibody molecules exhibit a wide range of binding specificities. The antigen‐binding properties of the antibody reside entirely in the amino‐terminal portion of the molecule, termed the variable domain. Structurally, the combining site specificity is determined by the amino‐acid residues within 6 short lengths, 3 each in the ...
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Science, 1978
Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin ...
J. G. Seidman +4 more
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Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin ...
J. G. Seidman +4 more
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The generation of antibody diversity in the turtle
The Journal of Immunology, 1996Abstract The Ab response in reptiles has been studied at the protein level, and in turtles some aspects resemble those of cold-blooded vertebrates from other classes. The genetic bases for these features are not clear. The present study is the first on the IgH organization and complexity of a reptilian Ig gene system.
A, Turchin, E, Hsu
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Somatic Generation of Antibody Diversity
Nature, 1983In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene.
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Generation of antibody diversity in rabbits
Current Opinion in Immunology, 1997Most rabbit B lymphocytes use the same VH gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs in the gut-associated lymphoid tissue.
K L, Knight, C R, Winstead
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Antibody diversity — how many antibody genes?
Trends in Biochemical Sciences, 1976Hybridization experiments with immunoglobulin messenger RNA (mRNA) reveal single or a limited number of variable region genes: the interpretation of this finding in terms of the origin of antibody diversity is discussed.
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AID Targeting in Antibody Diversity
2011Antibody maturation requires class switch recombination (CSR) and somatic hypermutation (SHM), both of which are initiated by activation-induced cytidine deaminase (AID). AID deaminates cytosine residues resulting in mismatches that are differentially processed to produce double-strand breaks in Ig switch (S) regions that lead to CSR, or to point ...
Rushad, Pavri, Michel C, Nussenzweig
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Somatic Mutation and Antibody Diversity
Survey and Synthesis of Pathology Research, 2008Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region ...
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