Results 171 to 180 of about 1,539 (210)
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Structural diversity of antibody catalysts
Journal of Immunological Methods, 2002The structural diversity of the immune response may be considerably restricted by the structure of the hapten used to elicit catalytic antibodies. The ligand-binding mode and the shapes of the binding pockets of hydrolytic antibodies induced to different transition-state analogs that contain an unsubstituted arylphosphonate group are very similar ...
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1981
Vertebrate organisms possess a large and diverse repertoire of antibody variable regions. A number of different genetic mechanisms have been proposed to account for immunoglobulin variable (V) region diversity, including multiple germline genes, somatic mutation, somatic recombination, and multiple small gene segments which are joined to form a ...
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Vertebrate organisms possess a large and diverse repertoire of antibody variable regions. A number of different genetic mechanisms have been proposed to account for immunoglobulin variable (V) region diversity, including multiple germline genes, somatic mutation, somatic recombination, and multiple small gene segments which are joined to form a ...
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The Biological Origin of Antibody Diversity
Annual Review of Biochemistry, 1976Antibody diversity has a compelling fascination for many scientists and over the years speculations have sometimes seemed more numerous than facts. Now the structural basis of antibody specificity is well defined. Amino acid sequences and recently three-dimensional structures of various immunoglobulins provide the most solid basis for discussing the ...
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Antibody and Immunoglobulin Diversity
BioScience, 1990Immunoglobulin (antibody) genes have been identified in extant species that are representative of critical points in the evolutionary radiations of vertebrates. The role of antibodies in host defense is well documented; antibodies confer a major selective advantage. In all species characterized, segments of the immunoglobulin genes rearrange during the
Gary W. Litman +3 more
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Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity
Science, 1983Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the ...
J L, Teillaud +7 more
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The roots of antibody diversity
Nature, 2002When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
exaly
Different classes of genomic inserts contribute to human antibody diversity
Proceedings of the National Academy of Sciences of the United States of America, 2022Christoph Ratswohl +2 more
exaly