Results 231 to 240 of about 394,452 (270)
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DNA Repair, Antibody Diversity, and Aging
Gerontology, 1985Proposed relationships of DNA repair, mutation, and the process of generation of antibody diversity allow new insights into the mechanism of aging. Pathways of antibody development are reviewed with special attention to steps which generate diversity. The normal process of combinatorial fusion of V region gene segments (i.e. V, D, and J) coding for the
R C, Johnson, A C, Wang
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Generation of antibody diversity in rabbits
Current Opinion in Immunology, 1997Most rabbit B lymphocytes use the same VH gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs in the gut-associated lymphoid tissue.
K L, Knight, C R, Winstead
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Germ line basis for antibody diversity
1975Each antibody polypeptide chain is the product of a gene pair comprising one constant (C) gene coding for that portion of the chain common to all chains of the same type and one variable (V) gene coding for the sequence unique to each chain. Previous evidence indicates that the haploid genome has a single copy of each distinct C gene and that for ...
Williamson, A R, Premkumar, E, Shoyab, M
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The Biological Origin of Antibody Diversity
Annual Review of Biochemistry, 1976Antibody diversity has a compelling fascination for many scientists and over the years speculations have sometimes seemed more numerous than facts. Now the structural basis of antibody specificity is well defined. Amino acid sequences and recently three-dimensional structures of various immunoglobulins provide the most solid basis for discussing the ...
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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Avidity in antibody effector functions and biotherapeutic drug design
Nature Reviews Drug Discovery, 2022Simone C Oostindie, Janine Schuurman
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