Results 211 to 220 of about 211,896 (251)
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Antibody diversity — how many antibody genes?
Trends in Biochemical Sciences, 1976Hybridization experiments with immunoglobulin messenger RNA (mRNA) reveal single or a limited number of variable region genes: the interpretation of this finding in terms of the origin of antibody diversity is discussed.
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AID Targeting in Antibody Diversity
2011Antibody maturation requires class switch recombination (CSR) and somatic hypermutation (SHM), both of which are initiated by activation-induced cytidine deaminase (AID). AID deaminates cytosine residues resulting in mismatches that are differentially processed to produce double-strand breaks in Ig switch (S) regions that lead to CSR, or to point ...
Rushad, Pavri, Michel C, Nussenzweig
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Somatic Mutation and Antibody Diversity
Survey and Synthesis of Pathology Research, 2008Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region ...
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Structural diversity of antibody catalysts
Journal of Immunological Methods, 2002The structural diversity of the immune response may be considerably restricted by the structure of the hapten used to elicit catalytic antibodies. The ligand-binding mode and the shapes of the binding pockets of hydrolytic antibodies induced to different transition-state analogs that contain an unsubstituted arylphosphonate group are very similar ...
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The Biological Origin of Antibody Diversity
Annual Review of Biochemistry, 1976Antibody diversity has a compelling fascination for many scientists and over the years speculations have sometimes seemed more numerous than facts. Now the structural basis of antibody specificity is well defined. Amino acid sequences and recently three-dimensional structures of various immunoglobulins provide the most solid basis for discussing the ...
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1981
Vertebrate organisms possess a large and diverse repertoire of antibody variable regions. A number of different genetic mechanisms have been proposed to account for immunoglobulin variable (V) region diversity, including multiple germline genes, somatic mutation, somatic recombination, and multiple small gene segments which are joined to form a ...
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Vertebrate organisms possess a large and diverse repertoire of antibody variable regions. A number of different genetic mechanisms have been proposed to account for immunoglobulin variable (V) region diversity, including multiple germline genes, somatic mutation, somatic recombination, and multiple small gene segments which are joined to form a ...
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Antibody and Immunoglobulin Diversity
BioScience, 1990Immunoglobulin (antibody) genes have been identified in extant species that are representative of critical points in the evolutionary radiations of vertebrates. The role of antibodies in host defense is well documented; antibodies confer a major selective advantage. In all species characterized, segments of the immunoglobulin genes rearrange during the
Gary W. Litman +3 more
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Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity
Science, 1983Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the ...
J L, Teillaud +7 more
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The roots of antibody diversity
Nature, 2002When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.
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