Results 21 to 30 of about 1,020,846 (330)

An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion

Bone Research, 2021
Osteoporosis (OP) is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.
Gehua Zhen, Yang Dan, Ruomei Wang, Ce Dou, Qiaoyue Guo, Melissa Zarr, Linda N. Liu, Lieping Chen, Ruoxian Deng, Yusheng Li, Zengwu Shao, Xu Cao   +11 more
doaj   +1 more source

Enhanced Photoluminescence Detection of Immunocomplex Formation by Antibody-Functionalized, Ge-Doped Biosilica from the Diatom Cyclotella sp.

Nanomaterials, 2023
Diatoms are single-celled algae that biosynthesize cell walls of biogenic silica called “frustules” that are intricately patterned at the submicron- and nanoscale.
Debra K. Gale, Gregory L. Rorrer
doaj   +1 more source

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons [PDF]

Journal of Experimental Medicine Aug 2019, 216 (8) 1904-1924, 2019
Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual ...
arxiv   +1 more source

Imunidade relacionada à resposta alérgica no início da vida Immunity related to allergic response at the beginning of life

Jornal de Pediatria, 2001
OBJETIVO: considerando-se que é na infância que as manifestações alérgicas mais comuns (asma, rinite, dermatite, alergia alimentar) ocorrem, porque é no início da vida que o sistema imune pode ser induzido à sensibilização ao invés de tolerância ...
Joaquina M.M. Correa, Antonio Zuliani
doaj   +1 more source

Idiotype-antiidiotypic interaction of antibodies in the bloodstream [PDF]

The Ukrainian Biochemical Journal, 2014
A problem of “prozone” formation in agglutination of corpuscular antibodies by bivalent antibodies­ was considered. Using a new coordinate system, which was proposed by us earlier, we analyzed theoretical and experimental curves that describe relations ...
S. A. Bobrovnik
doaj   +1 more source

Antibody Representation Learning for Drug Discovery [PDF]

arXiv, 2022
Therapeutic antibody development has become an increasingly popular approach for drug development. To date, antibody therapeutics are largely developed using large scale experimental screens of antibody libraries containing hundreds of millions of antibody sequences.
arxiv  

Factors of Innate and Adaptive Local Immunity in Children with Primary Deficiencies of Antibody Formation

Zdorovʹe Rebenka, 2013
In 40 children with various types of primary immunodeficiencies (PID) of antibody formation we examined factors of local immunity in saliva. It is found that in the saliva of children with PID of antibody formation in comparison with immunocompetent ...
L.I. Chernyshova, S.A. Yakymovych, A.V. Chernyshov, B.V. Donskoy, L.V. Stamboli   +4 more
doaj   +3 more sources

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Journal of Innate Immunity, 2022
Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous ...
Heidi Gytz Olesen, Iliana Michailidou, Wioleta M. Zelek, Jeroen Vreijling, Patrick Ruizendaal, Ferry de Klein, J. Arnoud Marquart, Thomas B. Kuipers, Hailiang Mei, Yuchun Zhang, Muhammad Ahasan, Krista K. Johnson, Yi Wang, B. Paul Morgan, Marcus van Dijk, Kees Fluiter, Gregers Rom Andersen, Frank Baas   +17 more
doaj   +1 more source

Antibody Watch: Text Mining Antibody Specificity from the Literature [PDF]

PLOS Computational Biology, 2021, 2020
Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading to unreliable research results.
arxiv   +1 more source

Immunological efficacy of Vaccination against Measles in Children with Down syndrome

Журнал инфектологии, 2014
The data of current vaccination process of cellular, humoral immunity and specific antibody formation in 41 children with Down syndrome at the age of 1 year to 6 years old is observed.
S. P. Kaplina, S. M. Kharit, E. I. Alexandrova   +2 more
doaj   +1 more source