Limited antibody specificity compromises epitranscriptomic analyses [PDF]
Nature Communications, 2019 A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Mark Helm, Frank Lyko, Yuri Motorin
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The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis [PDF]
Frontiers in Neurology, 2022 The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Lukas Leupold +9 more
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Antibody Watch: Text mining antibody specificity from the literature. [PDF]
PLoS Computational Biology, 2021 Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Chun-Nan Hsu +9 more
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Paratope plasticity determines anti-HER2 (4B5) antibody specificity [PDF]
mAbsThe PATHWAY anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody immunohistochemistry (IHC) assay is used to identify patients eligible for anti-HER2 targeted therapy.
P. Daniel Warren +7 more
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Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood [PDF]
Frontiers in Immunology, 2019 Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody ...
René H. M. Raeven +9 more
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Towards Understanding the Basis of Brucella Antigen–Antibody Specificity [PDF]
MoleculesBrucellosis continues to be a significant global zoonotic infection, with diagnosis largely relying on the detection of antibodies against the Brucella O-polysaccharide (O-PS) A and M antigens.
Amika Sood +2 more
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Characterization of a monoclonal antibody with specificity for holo-transcobalamin [PDF]
Nutrition & Metabolism, 2006 Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N +7 more
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Novel protocol for selection of SARS-CoV2 convalenscent plasma donors [PDF]
Vojnosanitetski Pregled, 2022 Background/Aim. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) 2019 infection represents a global problem. At this moment, in October 2020, there is no vaccine or efficient treatment for infected patients.
Ostojić Gordana +10 more
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The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]
, 2013 The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck +34 more
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Alternative Hapten Design for Zearalenone Immunoreagent Generation
Toxins, 2022 Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes +5 more
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