Results 1 to 10 of about 1,193,245 (372)

Antibody Watch: Text mining antibody specificity from the literature. [PDF]

PLoS Comput Biol, 2021
Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Hsu CN, Chang CH, Poopradubsil T, Lo A, William KA, Lin KW, Bandrowski A, Ozyurt IB, Grethe JS, Martone ME.   +9 more
europepmc   +3 more sources

The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis. [PDF]

Front Neurol, 2022
The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Leupold L, Sigutova V, Gerasimova E, Regensburger M, Zundler S, Zunke F, Xiang W, Winner B, Prots I.   +8 more
europepmc   +2 more sources

Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood. [PDF]

Front Immunol, 2019
Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody ...
Raeven RHM, van der Maas L, Pennings JLA, Fuursted K, Jørgensen CS, van Riet E, Metz B, Kersten GFA, Dalby T.   +8 more
europepmc   +2 more sources

Limited antibody specificity compromises epitranscriptomic analyses. [PDF]

Nat Commun, 2019
A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Helm M, Lyko F, Motorin Y.
europepmc   +2 more sources

Familial vasculitides: granulomatosis with polyangitis and microscopic polyangitis in two brothers with differing anti-neutrophil cytoplasm antibody specificity. [PDF]

Clin Kidney J, 2016
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a group of rare autoimmune diseases. Although the aetiology of AAV is uncertain, it is likely that genetic and environmental factors contribute.
Prendecki M, Cairns T, Pusey CD.
europepmc   +3 more sources

Specificity and application of SOX2 antibody

Poultry Science, 2020
Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its specificity and to use it to investigate the expression and distribution of Sox2 in the chicken brain ...
Pengxia Wang, Wende Wu, Lixia Wang, Ping Liu, Xiaoming Xu, Lingkang Liu, Jianhong Pan, Qingbo Xing, Gonghe Li, Jinyu Wei, Xibang Zheng, Longqin Wei   +11 more
openaire   +4 more sources

THE GENETIC CONTROL OF ANTIBODY SPECIFICITY [PDF]

The Journal of Experimental Medicine, 1969
The immune response to a synthetic polypeptide built on multichain polyproline, poly-L-(Tyr,Glu)-poly-L-Pro-poly-L-Lys [(T,G)-Pro--L], in the offspring of a cross between DBA/1 and SJL mice is under a genetic control superficially similar to the one operating for the immune response to a similar synthetic polypeptide built on multichain polyalanine ...
Mozes, E, Devitt, H O, Jaton, J, Sela, M
openaire   +5 more sources

Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction. [PDF]

PLoS Comput Biol
Antibodies play a crucial role in the adaptive immune response, with their specificity to antigens being a fundamental determinant of immune function.
Wang M, Patsenker J, Li H, Kluger Y, Kleinstein SH.   +4 more
europepmc   +2 more sources

Diagnostic value of BNLF2b antibody, dual-antibody testing and Epstein-Barr virus DNA in nasopharyngeal carcinoma: a prospective cohort study in Hunan Province, China. [PDF]

BMJ Open
Objectives This study evaluates the diagnostic value of the BNLF2b antibody, dual antibody testing and Epstein-Barr virus DNA (EBV-DNA) individually and in combination for nasopharyngeal carcinoma (NPC) detection.Design A prospective cohort study.Setting
Qu B, Sun L, Deng H, Liu Q, Shen H, Xiao P.   +5 more
europepmc   +2 more sources

The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]

, 2013
The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck, A Okamoto, AM Groeger, BC Soares de Sa, BE Gould Rotheberg, C Michaloglou, C Pilon, CQ Zhu, David Andrew Gunn, DE Marra, Dudley Ferdinando, F Haller, F Haller, G Volgareva, H Lin, HA McKenzie, Hong Wu, J Chen, J Lukas, Jeffrey Pawlikowski, JW Rocco, K Cuschieri, K Nilsson, M Dray, M Schutte, Magdalena Sawicka, Peter David Adams, R Klaes, S Pavey, Sophia N. Karagiannis, SS Wang, Stephen Wilson, WH Liggett Jr, William Parish, Y Cheng   +34 more
core   +14 more sources