Limited antibody specificity compromises epitranscriptomic analyses [PDF]
Nature Communications, 2019 A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Mark Helm, Frank Lyko, Yuri Motorin
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Ebola vaccine-induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects. [PDF]
Sci Transl Med, 2021 Fc effector functions and antibody specificity, rather than IgG or neutralizing titers, may serve as protective correlates for Ebola vaccines. Correlates of protection Vaccines against Ebola virus (EBOV) are difficult to test in humans due to the ...
Meyer M +20 more
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The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis [PDF]
Frontiers in Neurology, 2022 The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Lukas Leupold +9 more
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Antibody Watch: Text mining antibody specificity from the literature. [PDF]
PLoS Computational Biology, 2021 Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Chun-Nan Hsu +9 more
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Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing. [PDF]
Sci Rep, 2016 Disease-specific antibodies can serve as highly effective biomarkers but have been identified for only a relatively small number of autoimmune diseases.
Pantazes RJ +5 more
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Antibody specificity and promiscuity
Biochemical Journal, 2019 AbstractThe immune system is capable of making antibodies against anything that is foreign, yet it does not react against components of self. In that sense, a fundamental requirement of the body's immune defense is specificity. Remarkably, this ability to specifically attack foreign antigens is directed even against antigens that have not been ...
Deepti Jain, Dinakar M. Salunke
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Specificity and application of SOX2 antibody
Poultry Science, 2020 Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its ...
Longqin Wei +11 more
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Estimates of mumps seroprevalence may be influenced by antibody specificity and serologic method. [PDF]
Clin Vaccine Immunol, 2014 Neutralizing antibodies are assumed to be essential for protection against mumps virus infection, but their measurement is labor- and time-intensive.
Latner DR +5 more
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Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood [PDF]
Frontiers in Immunology, 2019 Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody ...
René H. M. Raeven +9 more
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Antimucopeptide Antibodies and Their Specificity [PDF]
The Journal of Immunology, 1969 Abstract The immunochemical specificity of the common part of bacterial mucopeptide, which is composed of the polysaccharide backbone and the peptide side chains, was studied in a heterologous system consisting of soluble, nondialyzable, lysozymedigest of M. lysodeikticus cell walls as test antigen and anti-S.
M Rolicka, James T. Park
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