Results 1 to 10 of about 656,519 (242)

The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis [PDF]

Frontiers in Neurology, 2022
The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Lukas Leupold, Veronika Sigutova, Elizaveta Gerasimova, Martin Regensburger, Martin Regensburger, Sebastian Zundler, Friederike Zunke, Wei Xiang, Beate Winner, Iryna Prots   +9 more
doaj   +2 more sources

Antibody Watch: Text mining antibody specificity from the literature. [PDF]

PLoS Computational Biology, 2021
Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Chun-Nan Hsu, Chia-Hui Chang, Thamolwan Poopradubsil, Amanda Lo, Karen A William, Ko-Wei Lin, Anita Bandrowski, Ibrahim Burak Ozyurt, Jeffrey S Grethe, Maryann E Martone   +9 more
doaj   +2 more sources

Limited antibody specificity compromises epitranscriptomic analyses [PDF]

Nature Communications, 2019
A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Mark Helm, Frank Lyko, Yuri Motorin
doaj   +2 more sources

Paratope plasticity determines anti-HER2 (4B5) antibody specificity [PDF]

mAbs
The PATHWAY anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody immunohistochemistry (IHC) assay is used to identify patients eligible for anti-HER2 targeted therapy.
P. Daniel Warren, Terry H. Landowski, Mark S. Dodson, Adnan Gulzar, John D. Palting, Erika Walker, Penny Towne, Margaret H. Smith   +7 more
doaj   +2 more sources

Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood [PDF]

Frontiers in Immunology, 2019
Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody ...
René H. M. Raeven, Larissa van der Maas, Jeroen L. A. Pennings, Kurt Fuursted, Charlotte Sværke Jørgensen, Elly van Riet, Bernard Metz, Gideon F. A. Kersten, Gideon F. A. Kersten, Tine Dalby   +9 more
doaj   +2 more sources

Towards Understanding the Basis of Brucella Antigen–Antibody Specificity [PDF]

Molecules
Brucellosis continues to be a significant global zoonotic infection, with diagnosis largely relying on the detection of antibodies against the Brucella O-polysaccharide (O-PS) A and M antigens.
Amika Sood, David R. Bundle, Robert J. Woods   +2 more
doaj   +2 more sources

Novel immunohistochemical assay utilizing the INSM1 (SP493) antibody demonstrates high specificity and sensitivity in detecting primary neuroendocrine lung neoplasms [PDF]

Diagnostic Pathology
Introduction About 15–20% of lung neoplasms are of neuroendocrine origin. In addition to evaluation of morphological features, these neoplasms can be identified by immunohistochemistry (IHC) using antibodies against neuroendocrine markers such as ...
Katerina Dvorak, Alexander Gomez, Rafael Sainz   +2 more
doaj   +2 more sources

Novel protocol for selection of SARS-CoV2 convalenscent plasma donors [PDF]

Vojnosanitetski Pregled, 2022
Background/Aim. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) 2019 infection represents a global problem. At this moment, in October 2020, there is no vaccine or efficient treatment for infected patients.
Ostojić Gordana, Šupić Gordana, Karličić Vukoica, Karličić Marija, Ristanović Elizabeta, Kovačević Milan, Abazović Džihan, Gojkov Dragana, Stanojević Ivan, Vukosavljević Miroslav, Vojvodić Danilo   +10 more
doaj   +1 more source

Alternative Hapten Design for Zearalenone Immunoreagent Generation

Toxins, 2022
Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes, Consuelo Agulló, Daniel López-Puertollano, Ismael Navarro-Fuertes, Antonio Abad-Somovilla, Josep Vicent Mercader   +5 more
doaj   +1 more source

A strong case for third-party testing

eLife, 2023
A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
Fridtjof Lund-Johansen
doaj   +1 more source