Antibody Watch: Text mining antibody specificity from the literature. [PDF]
PLoS Computational Biology, 2021 Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Chun-Nan Hsu +9 more
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Limited antibody specificity compromises epitranscriptomic analyses [PDF]
Nature Communications, 2019 A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Mark Helm, Frank Lyko, Yuri Motorin
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THE GENETIC CONTROL OF ANTIBODY SPECIFICITY [PDF]
The Journal of Experimental Medicine, 1969 The immune response to a synthetic polypeptide built on multichain polyproline, poly-L-(Tyr,Glu)-poly-L-Pro-poly-L-Lys [(T,G)-Pro--L], in the offspring of a cross between DBA/1 and SJL mice is under a genetic control superficially similar to the one ...
Jaton, Jean-Claude +3 more
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Ebola vaccine-induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects. [PDF]
Sci Transl Med, 2021 Fc effector functions and antibody specificity, rather than IgG or neutralizing titers, may serve as protective correlates for Ebola vaccines. Correlates of protection Vaccines against Ebola virus (EBOV) are difficult to test in humans due to the ...
Meyer M +20 more
europepmc +2 more sources
The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis [PDF]
Frontiers in Neurology, 2022 The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Lukas Leupold +9 more
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Analysis of Histone Antibody Specificity with Peptide Microarrays. [PDF]
J Vis Exp, 2017 Post-translational modifications (PTMs) on histone proteins are widely studied for their roles in regulating chromatin structure and gene expression.
Cornett EM, Dickson BM, Rothbart SB.
europepmc +2 more sources
Antibody specificity and promiscuity
Biochemical Journal, 2019 AbstractThe immune system is capable of making antibodies against anything that is foreign, yet it does not react against components of self. In that sense, a fundamental requirement of the body's immune defense is specificity. Remarkably, this ability to specifically attack foreign antigens is directed even against antigens that have not been ...
Deepti Jain, Dinakar M. Salunke
openaire +4 more sources
Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. [PDF]
Arthritis Rheumatol, 2018 To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3‐ANCA] versus myeloperoxidase ANCA ...
Berti A +18 more
europepmc +2 more sources
Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. [PDF]
J Virol, 2014 Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities.
Liu P +14 more
europepmc +2 more sources
Estimates of mumps seroprevalence may be influenced by antibody specificity and serologic method. [PDF]
Clin Vaccine Immunol, 2014 Neutralizing antibodies are assumed to be essential for protection against mumps virus infection, but their measurement is labor- and time-intensive.
Latner DR +5 more
europepmc +2 more sources