Antibody Watch: Text mining antibody specificity from the literature. [PDF]
Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading ...
Chun-Nan Hsu+9 more
doaj +2 more sources
The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis [PDF]
The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive.
Lukas Leupold+9 more
doaj +2 more sources
Limited antibody specificity compromises epitranscriptomic analyses [PDF]
A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
Mark Helm, Frank Lyko, Yuri Motorin
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Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood [PDF]
Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody ...
René H. M. Raeven+9 more
doaj +2 more sources
Towards Understanding the Basis of Brucella Antigen–Antibody Specificity [PDF]
Brucellosis continues to be a significant global zoonotic infection, with diagnosis largely relying on the detection of antibodies against the Brucella O-polysaccharide (O-PS) A and M antigens.
Amika Sood+2 more
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Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization [PDF]
Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ ...
Lin Sun+8 more
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The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]
The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck+34 more
core +11 more sources
Alternative Hapten Design for Zearalenone Immunoreagent Generation
Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes+5 more
doaj +1 more source
Novel protocol for selection of SARS-CoV2 convalenscent plasma donors [PDF]
Background/Aim. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) 2019 infection represents a global problem. At this moment, in October 2020, there is no vaccine or efficient treatment for infected patients.
Ostojić Gordana+10 more
doaj +1 more source
A strong case for third-party testing
A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
Fridtjof Lund-Johansen
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