Results 11 to 20 of about 9,814,118 (327)

Towards Understanding the Basis of Brucella Antigen–Antibody Specificity [PDF]

Molecules
Brucellosis continues to be a significant global zoonotic infection, with diagnosis largely relying on the detection of antibodies against the Brucella O-polysaccharide (O-PS) A and M antigens.
Amika Sood, David R. Bundle, Robert J. Woods   +2 more
doaj   +2 more sources

Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization [PDF]

Antibodies
Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ ...
Lin Sun, Roman Palt, Georg Schütz, Esther Föderl-Höbenreich, Laura Brod, Antonia Hermle, Anja Lux, Herta Steinkellner, Somanath Kallolimath   +8 more
doaj   +2 more sources

THE GENETIC CONTROL OF ANTIBODY SPECIFICITY [PDF]

The Journal of Experimental Medicine, 1969
The immune response to a synthetic polypeptide built on multichain polyproline, poly-L-(Tyr,Glu)-poly-L-Pro-poly-L-Lys [(T,G)-Pro--L], in the offspring of a cross between DBA/1 and SJL mice is under a genetic control superficially similar to the one operating for the immune response to a similar synthetic polypeptide built on multichain polyalanine ...
Edna Mozes, Hugh O. McDevitt, Jean‐Claude Jaton, Michael Sela   +3 more
openalex   +5 more sources

Analysis of Histone Antibody Specificity with Peptide Microarrays. [PDF]

J Vis Exp, 2017
Cornett EM, Dickson BM, Rothbart SB.
europepmc   +2 more sources

An Interactive Database for the Assessment of Histone Antibody Specificity. [PDF]

Mol Cell, 2015
Rothbart SB, Dickson BM, Raab JR, Grzybowski AT, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Strahl BD.   +12 more
europepmc   +2 more sources

Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. [PDF]

J Virol, 2014
Liu P, Williams LD, Shen X, Bonsignori M, Vandergrift NA, Overman RG, Moody MA, Liao HX, Stieh DJ, McCotter KL, French AL, Hope TJ, Shattock R, Haynes BF, Tomaras GD.   +14 more
europepmc   +2 more sources

Editorial: Antibody can get it right: confronting problems of antibody specificity and irreproducibility.

Mol Endocrinol, 2014
Schonbrunn A.
europepmc   +2 more sources

Novel protocol for selection of SARS-CoV2 convalenscent plasma donors [PDF]

Vojnosanitetski Pregled, 2022
Background/Aim. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) 2019 infection represents a global problem. At this moment, in October 2020, there is no vaccine or efficient treatment for infected patients.
Ostojić Gordana, Šupić Gordana, Karličić Vukoica, Karličić Marija, Ristanović Elizabeta, Kovačević Milan, Abazović Džihan, Gojkov Dragana, Stanojević Ivan, Vukosavljević Miroslav, Vojvodić Danilo   +10 more
doaj   +1 more source

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

bioRxiv, 2023
Despite decades of antibody research, it remains challenging to predict the specificity of an antibody solely based on its sequence. Two major obstacles are the lack of appropriate models and inaccessibility of datasets for model training. In this study,
Yiquan Wang, Huibin Lv, R. Lei, Yuen-Hei Yeung, Ivana R. Shen, Danbi Choi, Qi Wen Teo, Timothy J. C. Tan, Akshita B. Gopal, Xin Chen, Claire S. Graham, Nicholas C. Wu   +11 more
semanticscholar   +1 more source

Unconstrained generation of synthetic antibody-antigen structures to guide machine learning methodology for antibody specificity prediction

Nature Computational Science, 2022
Machine learning (ML) is a key technology for accurate prediction of antibody-antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: the lack of a unified ML formalization of
Philippe A. Robert, R. Akbar, R. Frank, Milena Pavlović, Michael Widrich, I. Snapkov, Andrei Slabodkin, Maria Chernigovskaya, Lonneke Scheffer, Eva Smorodina, Puneet Rawat, Brij Bhushan Mehta, Mai Ha Vu, Ingvild Frøberg Mathisen, Aurél Prósz, K. Abram, Alexandru Olar, Enkelejda Miho, Dag Trygve Tryslew Haug, F. Lund-Johansen, Sepp Hochreiter, I. H. Haff, G. Klambauer, G. K. Sandve, V. Greiff   +24 more
semanticscholar   +1 more source