Results 21 to 30 of about 656,519 (242)

Structurally Mapping Antibody Repertoires

Frontiers in Immunology, 2018
Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq).
Konrad Krawczyk, Sebastian Kelm, Aleksandr Kovaltsuk, Jacob D. Galson, Dominic Kelly, Johannes Trück, Johannes Trück, Cristian Regep, Jinwoo Leem, Wing K. Wong, Jaroslaw Nowak, James Snowden, Michael Wright, Laura Starkie, Anthony Scott-Tucker, Jiye Shi, Charlotte M. Deane   +16 more
doaj   +1 more source

Antibody variable region engineering for improving cancer immunotherapy

Cancer Communications, 2022
The efficacy and specificity of conventional monoclonal antibody (mAb) drugs in the clinic require further improvement. Currently, the development and application of novel antibody formats for improving cancer immunotherapy have attracted much attention.
Hantao Lou, Xuetao Cao
doaj   +1 more source

The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years

Frontiers in Microbiology, 2017
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy.
Alfonsina Trento, Alfonsina Trento, Rosa Rodríguez-Fernández, María I. González-Sánchez, Felipe González-Martínez, Vicente Mas, Vicente Mas, Mónica Vázquez, Mónica Vázquez, Concepción Palomo, Concepción Palomo, José A. Melero, José A. Melero   +12 more
doaj   +1 more source

Platelet antibody of blood donors in Suzhou

Zhongguo shuxue zazhi, 2022
Objective To study the incidence and specificity of platelet antibody in blood donors in Suzhou, analyze the distribution characteristics of platelet antibody in blood donors in this area, and explore the significance of platelet antibody detection in ...
Li DONG, Ming FANG, Yujue WANG, Honghong HE, Hongmei WANG, Yezhou CHEN, Feiran Wu, Shengbao DUAN, Longhai TANG   +8 more
doaj   +1 more source

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

Scientific Reports, 2022
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces.
Hung-Pin Peng, Hung-Ju Hsu, Chung-Ming Yu, Fei-Hung Hung, Chao-Ping Tung, Yu-Chuan Huang, Chi-Yung Chen, Pei-Hsun Tsai, An-Suei Yang   +8 more
doaj   +1 more source

Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

mAbs, 2021
Antibody-based drugs, which now represent the dominant biologic therapeutic modality, are used to modulate disparate signaling pathways across diverse disease indications.
Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou, William J.J. Finlay   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in Escherichia coli

Frontiers in Bioengineering and Biotechnology
IntroductionRecombinant single‐chain variable fragments (scFvs) are promising antibody formats for cost‐effective and scalable production. However, their soluble expression in Escherichia coli is often limited by misfolding and aggregation, particularly ...
Shimiao Chen, Shimiao Chen, Shimiao Chen, Bin Shan, Bin Shan, Yican Luo, Ganhui Mo, Ganhui Mo, Ganhui Mo, Usman Rasheed, Usman Rasheed, Usman Rasheed, Lilan Lv, Lilan Lv, Xinyu Yang, Qinyu Lu, Qinyu Lu, Qinyu Lu   +17 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

mAbs, 2021
Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear.
Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson, Daniel Christ   +19 more
doaj   +1 more source