Results 21 to 30 of about 9,814,118 (327)

Alternative Hapten Design for Zearalenone Immunoreagent Generation

Toxins, 2022
Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes, Consuelo Agulló, Daniel López-Puertollano, Ismael Navarro-Fuertes, Antonio Abad-Somovilla, Josep Vicent Mercader   +5 more
doaj   +1 more source

Unconstrained generation of synthetic antibody-antigen structures to guide machine learning methodology for real-world antibody specificity prediction

bioRxiv, 2021
Machine learning (ML) is a key technology for accurate prediction of antibody-antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: The lack of a unified ML formalization of
Philippe A. Robert, R. Akbar, R. Frank, Milena Pavlović, Michael Widrich, I. Snapkov, Andrei Slabodkin, Maria Chernigovskaya, Lonneke Scheffer, Eva Smorodina, Puneet Rawat, Brij Bhushan Mehta, Mai Ha Vu, Ingvild Frøberg Mathisen, Aurél Prósz, K. Abram, Alexandru Olar, Enkelejda Miho, Dag Trygve Tryslew Haug, F. Lund-Johansen, Sepp Hochreiter, I. H. Haff, G. Klambauer, G. K. Sandve, V. Greiff   +24 more
semanticscholar   +1 more source

A strong case for third-party testing

eLife, 2023
A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
Fridtjof Lund-Johansen
doaj   +1 more source

Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?

Biomolecules, 2020
Alpha7 nicotinic acetylcholine receptors (α7nAChRs) are interesting not only because of their physiological effects, but because this receptor requires chaperones to traffic to cell surfaces (measured by alpha-bungarotoxin [αBGT] binding ...
Anish Deshpande, Remitha M. Vinayakamoorthy, Brijesh K. Garg, Jaya Prakash Thummapudi, Gauri Oza, Ketaki Adhikari, Aayush Agarwal, Parnika Dalvi, Swetha Iyer, Sarulatha Thulasi Raman, Vijay Ramesh, Akshitha Rameshbabu, Alexandra Rezvaya, Sneha Sukumaran, Sweta Swaminathan, Bhargav Tilak, Zhiyuan Wang, Phu V. Tran, Ralph H. Loring   +18 more
doaj   +1 more source

Antibody-specific immunoregulation [PDF]

The Journal of Experimental Medicine, 1977
In recent years, much evidence has accumulated which demonstrates that an animal's immune system has the capacity to recognize its own antibody idiotypes. These findings suggest that self-idiotypic recognition may potentially play a role in the regulation of B-cell responses.
Norman R. Klinman, Susan K. Pierce
openaire   +3 more sources

Frequency of alloantibody with their specification among multitransfused patients

Global Journal of Transfusion Medicine, 2020
Background and Objectives: Alloimmunization is a very common clinical problem in transfusion-dependent patients but rarely detected in Bangladesh.
Ayesha Khatun, Munshi Md Habibullah, Daanish Arefin Biswas, Md Abdul Quader, Jolly Biswas   +4 more
doaj   +1 more source

Specificities of Antibodies to Normetanephrine [PDF]

European Journal of Biochemistry, 1972
Antibodies to normetanephrine were produced in rabbits by immunization with conjugates synthesized by linking the amino group of the hapten to the amino groups of the carrier macromolecules using glutaraldehyde. The antibodies are highly specific for the ring structure of the normetanephrine molecule and also recognize substitutions in the side chain ...
Bernhard A. Peskar, Lawrence Levine, Brigitte M. Peskar   +2 more
openaire   +3 more sources

Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

Frontiers in Immunology, 2017
Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines.
Ekaterina A. Kurbatova, Nelli K. Akhmatova, Elina A. Akhmatova, Nadezhda B. Egorova, Natalya E. Yastrebova, Elena V. Sukhova, Dmitriy V. Yashunsky, Yury E. Tsvetkov, Marina L. Gening, Nikolay E. Nifantiev   +9 more
doaj   +1 more source

IgG Study of Blood Sera of Patients with COVID-19

Pathogens, 2021
The COVID-19 pandemic, which began at the end of 2019 in Wuhan, has affected 220 countries and territories to date. In the present study, we studied humoral immunity in samples of the blood sera of COVID-19 convalescents of varying severity and patients ...
Elena Kazachinskaia, Alexander Chepurnov, Dmitry Shcherbakov, Yulia Kononova, Teresa Saroyan, Marina Gulyaeva, Daniil Shanshin, Valeriya Romanova, Olga Khripko, Michail Voevoda, Alexander Shestopalov   +10 more
doaj   +1 more source

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source