Results 21 to 30 of about 849,234 (288)
AntiBARTy Diffusion for Property Guided Antibody Design [PDF]
arXiv, 2023 Over the past decade, antibodies have steadily grown in therapeutic importance thanks to their high specificity and low risk of adverse effects compared to other drug modalities. While traditional antibody discovery is primarily wet lab driven, the rapid improvement of ML-based generative modeling has made in-silico approaches an increasingly viable ...
arxiv
Scientific Reports, 2022 Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces.
Hung-Pin Peng +8 more
doaj +1 more source
mAbs, 2021 Antibody-based drugs, which now represent the dominant biologic therapeutic modality, are used to modulate disparate signaling pathways across diverse disease indications.
Orla Cunningham +3 more
doaj +1 more source
On Pre-trained Language Models for Antibody [PDF]
arXiv, 2023 Antibodies are vital proteins offering robust protection for the human body from pathogens. The development of general protein and antibody-specific pre-trained language models both facilitate antibody prediction tasks. However, there have been limited studies that comprehensively explore the representation capability of distinct pre-trained language ...
arxiv
ASAP-SML: An Antibody Sequence Analysis Pipeline Using Statistical Testing and Machine Learning [PDF]
, 2020 Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of antibodies to their unique properties as inhibitors.
arxiv +1 more source
Structurally Mapping Antibody Repertoires
Frontiers in Immunology, 2018 Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq).
Konrad Krawczyk +16 more
doaj +1 more source
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
mAbs, 2021 Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear.
Romain Rouet +19 more
doaj +1 more source
xTrimoABFold: De novo Antibody Structure Prediction without MSA [PDF]
arXiv, 2022 In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function.
arxiv
Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, Benin
Emerging Infectious Diseases, 2021 We used commercially available ELISAs to test 68 samples from coronavirus disease cases and prepandemic controls from Benin. We noted
Anges Yadouleton +16 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source