Results 41 to 50 of about 9,814,118 (327)

The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years

Frontiers in Microbiology, 2017
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy.
Alfonsina Trento, Alfonsina Trento, Rosa Rodríguez-Fernández, María I. González-Sánchez, Felipe González-Martínez, Vicente Mas, Vicente Mas, Mónica Vázquez, Mónica Vázquez, Concepción Palomo, Concepción Palomo, José A. Melero, José A. Melero   +12 more
doaj   +1 more source

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

Scientific Reports, 2022
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces.
Hung-Pin Peng, Hung-Ju Hsu, Chung-Ming Yu, Fei-Hung Hung, Chao-Ping Tung, Yu-Chuan Huang, Chi-Yung Chen, Pei-Hsun Tsai, An-Suei Yang   +8 more
doaj   +1 more source

Specific Suppression of the Antibody Response by Antibodies to Receptors [PDF]

Proceedings of the National Academy of Sciences, 1972
Balb/c myeloma proteins, TEPC 15 and MOPC 167, bind phosphorylcholine and precipitate with the C-polysaccharide moiety of pneumococci R36A. Anti-idiotypic antibodies to TEPC 15 myeloma raised in A/He mice prevent plaque formation by cells releasing antibody to phosphorylcholine and inhibit induction of the antibody response to ...
Cosenza, H, Kohler, H
openaire   +3 more sources

Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

mAbs, 2021
Antibody-based drugs, which now represent the dominant biologic therapeutic modality, are used to modulate disparate signaling pathways across diverse disease indications.
Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou, William J.J. Finlay   +3 more
doaj   +1 more source

Net charge of antibody complementarity-determining regions is a key predictor of specificity.

Protein engineering, design & selection : PEDS, 2018
Specificity is one of the most important and complex properties that is central to both natural antibody function and therapeutic antibody efficacy.
Lilia A. Rabia, Yulei Zhang, Seth D. Ludwig, Mark C. Julian, P. Tessier   +4 more
semanticscholar   +1 more source

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

Science immunology, 2020
Illness severity in COVID-19 correlates with specificity of serological responses, but antibody levels decrease in most patients. SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with ...
K. Röltgen, Abigail E. Powell, O. Wirz, Bryan A. Stevens, C. Hogan, J. Najeeb, Molly Hunter, Hannah Wang, M. Sahoo, ChunHong Huang, F. Yamamoto, M. Manohar, Justin Manalac, A. R. Otrelo-Cardoso, T. Pham, A. Rustagi, A. Rogers, N. Shah, C. Blish, J. Cochran, T. Jardetzky, J. Zehnder, Taia T. Wang, B. Narasimhan, S. Gombar, R. Tibshirani, K. Nadeau, P. Kim, B. Pinsky, S. Boyd   +29 more
semanticscholar   +1 more source

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance In addition to neutralizing antigens, antibodies are also capable of stimulating cellular responses through Fc–Fc receptor interactions.
Wenqian He, G. Tan, Caitlin E. Mullarkey, Amanda J. Lee, M. Lam, F. Krammer, Carole J Henry, P. Wilson, A. Ashkar, P. Palese, Matthew S. Miller   +10 more
semanticscholar   +1 more source

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

mAbs, 2021
Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear.
Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson, Daniel Christ   +19 more
doaj   +1 more source

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

Journal of Biological Chemistry, 2017
Antibodies commonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostatic interactions.
K. Tiller, Lijuan Li, Sandeep Kumar, Mark C. Julian, S. Garde, P. Tessier   +5 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source